2020
DOI: 10.32932/pjnh.2020.01.047
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Nephrotoxicity in patients receiving immune checkpoint inhibitors

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Cited by 1 publication
(4 citation statements)
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“…The kidney is thought to be one of the most important organs affected by ICPIs. Although early reports presented a lower prevalence of renal disturbances after ICPIs administration (at around 2%), newer studies show a 29% incidence which is considered to be relatively high (18)(19)(20)(21). Seethapathy et al evaluated 1016 individuals with an average age of 63 ±13 years (61% were men), with a mean serum creatinine of 0.9 ±0.4 mg/dL at baseline.…”
Section: An Overview Of Renal Injury By Icpismentioning
confidence: 99%
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“…The kidney is thought to be one of the most important organs affected by ICPIs. Although early reports presented a lower prevalence of renal disturbances after ICPIs administration (at around 2%), newer studies show a 29% incidence which is considered to be relatively high (18)(19)(20)(21). Seethapathy et al evaluated 1016 individuals with an average age of 63 ±13 years (61% were men), with a mean serum creatinine of 0.9 ±0.4 mg/dL at baseline.…”
Section: An Overview Of Renal Injury By Icpismentioning
confidence: 99%
“…Finally, direct binding of an ICPI to its specific receptor present on normal tissues will activate complement-mediated inflammation. This condition may deteriorate lesions that are already present in healthy tissue (18) since numerous antigens present on cancer cells are also expressed on normal tissues (17).…”
Section: The Mechanisms Of Renal Toxicity Due To Icpi Treatmentmentioning
confidence: 99%
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