Nephrotoxicity induced by natural compounds from herbal medicines – a challenge for clinical application

Potential therapeutic effects of Chinese meteria medica in mitigating drug-induced acute kidney injury

“…Koch., etc. , Containing toxic proteins; h) Other toxic components include Mylabris phalerata Pallas (Cantharidin), Cnidium monnieri (L.) Cusson (Osthole), etc., ( Rao et al, 2022 ; Tian et al, 2022 ; Zhang et al, 2023 ). Incidences of DI-AKI caused by botanical drugs are unknown, which should be considered by clinicians when acquiring patient history.…”

Comprehensive HRMS Screening and Risk Assessments of Aristolochic Acid Analogues in Asari Radix et Rhizoma and Related Commercial Health Products

“…2 AA I is enzymatically reduced by enzymes such as quinone oxidoreductase (NQO1) or cytochrome P450 1A1/2 (CYP1A1/2), resulting in the formation of reactive intermediates that form DNA adducts. 3 The permanence and irreversibility of the damage induced by these DNA adducts, which disrupt normal cellular functions, have resulted in AA I being classified as a Group 1 carcinogen by the International Agency for Research on Cancer (IARC). 4 In some Belgian AAN patients, AA-derived DNA adducts have been demonstrated to persist in kidney for over 20 years even after discontinuation of AA I-containing drugs.…”

“…The acknowledged nephrotoxicity and mutagenicity of AA I, coupled with its carcinogenic impact on the transitional epithelial cells of the upper urinary tract, can lead to progressive renal failure, a condition commonly known as “Chinese herb nephropathy” (CHN) or “aristolochic acid nephropathy (AAN)″ . AA I is enzymatically reduced by enzymes such as quinone oxidoreductase (NQO1) or cytochrome P450 1A1/2 (CYP1A1/2), resulting in the formation of reactive intermediates that form DNA adducts . The permanence and irreversibility of the damage induced by these DNA adducts, which disrupt normal cellular functions, have resulted in AA I being classified as a Group 1 carcinogen by the International Agency for Research on Cancer (IARC) .…”

Rational design of a ratiometric fluorescent aptasensor for patulin in traditional Chinese medicine through the studies of the interaction mechanism between its DNA aptamer and the target molecule

“…14,15 Therefore, it is necessary to strictly control mycotoxins in TCM for the sake of quality and safety. However, the components of TCM are quite complex 16 and play an interfering role, making it difficult to detect mycotoxins quickly and accurately in the actual sample. At the same time, conventional detection methods for mycotoxins, such as chromatography, mass spectrometry and enzyme-linked immunosorbent assays, are limited in practical application due to their high cost, complicated operation, and cumbersome pretreatment process.…”