Nephrotoxicity of gasoline fumes in male albino rat: a mechanism-based approach study

Owagboriaye, Folarin; Aina, Sulaimon; Oladunjoye, Rasheed; Salisu, Titilola; Adenekan, Adedamola; Aladesida, Adeyinka; Dedeke, G. A.

doi:10.1080/26895293.2022.2131635

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…This could have been due to the shrinking of the glomerulus and dilatation of the bowman's capsule. Previous studies from the literature reviewed (Owagboriaye et al, 2022;Tobar et al, 2013) also recorded a significance increase in the enlargement of glomerulus space as a result of hyperfiltration of the glomerulus space and degeneration of the glomerulus capillaries when exposed to nephrotoxic agents. There was no significance increase in the surface area of the glomerulus space of the experimental three as compared to the control thus this may suggest reconstructive restoration.…”

Section: Discussionmentioning

confidence: 87%

Restorative effects of <i>Azadicarachta indica</i> on the kidney histomorphometry in cisplatintreated Wister albino rats

Edwin,

Domnic,

Norman

2023

Anat. J. Afr.

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Background: Cisplatin is used for treatment of soft tissue tumors and has been associated with nephrotoxicity. Azadirachta indica is a local herb that has been associated with attenuation and counteracting the nephrotoxic effects of cisplatin. However, there is inadequate histomorphometric evidence to support this potential. This study therefore aims to evaluate the possible Restorative Effects of Azadirachta indica on Kidney Histomorphometry in Cisplatin-Treated Wister Albino Rats. Methods: Twenty-five Wister Albino Rats of weight 250-400g were randomly selected into five groups of control or experimental with each group containing five animals. The control group only fed on water adlibitum. Experimental group one was administered with intraperitoneal injection 0.28mg/kg of cisplatin, other three experimental groups were given a constant dose of intraperitoneal 0.28mg/kg of cisplatin on day one followed by per oral 6.67mg/kg/bwt/day experimental group two, 5mg/kg/bwt/day experimental group three and 3.33mg/kg/bwt/day experimental group four of azadiracta indica on day five for seven days. On day thirteen all animals were euthanized. The kidneys were histologically prepared. Photomicrographs were taken and uploaded on stepanizer for histostereology. Results: The glomerulus and the Bowmans capsule of experimental group one, two and four had a significant (P ≤ 0.0001) reduction and increased respectively, only the glomerulus space for the experimental group two had significant (P ≤ 0.002) increase as compared to the control. Conclusion: Out of the three doses of azadicracta indica, the medium dose of 5.0mg/kg was able to restore the histomorphometry and histostereology of the kidney on administration of 0.28mg/kg of cisplatin.

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Section: Discussionmentioning

confidence: 87%

Restorative effects of <i>Azadicarachta indica</i> on the kidney histomorphometry in cisplatintreated Wister albino rats

Edwin,

Domnic,

Norman

2023

Anat. J. Afr.

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“…They mentioned that in all groups exposed to petroleum products, there was a rise in levels of creatinine, serum urea, and serum electrolytes (sodium, potassium, and chloride) compared to the control group. [19] studied the effects of exposure to gasoline fumes for 1-9 hours per day for ten weeks on the kidneys of male albino rats. The exposed rats showed significant alterations (p < 0.05) in the biochemical markers tested in their blood and kidneys compared to the control group.…”

Section: Resultsmentioning

confidence: 99%

Assessment of the Toxicity Effects of Inhalation Exposure to Kerosene and Naphtha Fumes on some Liver and Kidney Parameters in Rats

Kadum,

Al-Hakkak

2024

IOP Conf. Ser.: Earth Environ. Sci.

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Exposure to petroleum compounds and vapours has been shown to have harmful effects on many different organs and systems of the body, especially the liver. This study aimed to evaluate the effects of kerosene & naphtha vapours on some liver and kidney parameters in rats. Twenty male Wistar albino rats were used in the study; the rats were separated into four groups, each with five rats: three for testing and one for control. Using an altered nose-inhalation exposure approach, rats were exposed to kerosene vapours for six hours daily for 15, 30 and 45 days. The study measured the parameters of blood in rats after they were sacrificed. The study revealed a significant rise (P≥0.01) in the levels of serum aspartate aminotransferase (A.S.T.), alkaline phosphatase (A.L.P.), and alanine aminotransferase catalase (A.L.T.) in rats exposed to kerosene and naphtha fumes for 15, 30, and 45 days, as compared to the control group. The findings also indicated a statistically significant (P≥0.01) increase in the serum bilirubin levels of rats exposed to kerosene and naphtha fumes for 15, 30, and 45 days compared to the control group. The findings demonstrated a statistically significant increase (p≥0.05) in serum creatinine and serum urea levels in rats exposed to kerosene and naphtha fumes for 25, 30, and 45 days compared to the control group. Additionally, the study demonstrated a significant increase (p≥0.05) in serum creatinine levels in rats exposed to kerosene fumes for 45 days compared to rats exposed for 15 and 30 days. It may be concluded that the liver parameters were negatively impacted by inhaling fumes containing Kerosene and naphtha.

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Nephrotoxicity of gasoline fumes in male albino rat: a mechanism-based approach study

Cited by 2 publications

References 41 publications

Restorative effects of <i>Azadicarachta indica</i> on the kidney histomorphometry in cisplatintreated Wister albino rats

Restorative effects of <i>Azadicarachta indica</i> on the kidney histomorphometry in cisplatintreated Wister albino rats

Assessment of the Toxicity Effects of Inhalation Exposure to Kerosene and Naphtha Fumes on some Liver and Kidney Parameters in Rats

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