Nephrotoxicity of Iodinated Contrast Media: A Preliminary Report on Five Compounds Used for Urography

Pinet, Agnès; Vincent, C.; Révillard, J. P.; Pozet, N; Bertrand, J L

doi:10.1007/978-3-642-68584-2_46

Cited by 2 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diatrizoate in duced a marked increase in the urinary excretion of both brush-border enzymes (AAP and y-GT), while iopamidol gave only a slight and transient increase in y-GT excre tion. Neither contrast drug induced significant changes in the urinary excretion of the lysosomal enzyme, NAG, as previously also reported by others [22][23][24]. However, Hartman et al [25] found a significant elevation of both brush-border enzymes and NAG after intravenous ad ministration or a conventional dose of meglumine diatrizoate in subjects with normal renal function.…”

Section: Discussionmentioning

confidence: 38%

Tubular Nephrotoxicity after Intravenous Urography with Ionic High-Osmolal and Nonionic Low-Osmolal Contrast Media in Patients with Chronic Renal Insufficiency

Cavaliere¹,

Arrigo²,

D’Amico³

et al. 1987

Nephron

View full text Add to dashboard Cite

Nephrotoxicity of intravenous contrast media is more frequent and striking in patients with risk factors, the major one being preexisting chronic renal insufficiency. New nonionic low-osmolal contrast media allegedly have less nephrotoxicity than the traditional ionic high-osmolal ones. This was tested for two contrast media in a group of 18 patients with stable chronic renal insufficiency. The urinary excretion of two brush-border enzymes (alanine aminopeptidase, AAP, and γ-glutamyl transpeptidase, γ-GT) and of a lysosomal enzyme (N-acetyl-β glucosaminidase, NAG), functional markers of tubular injury, were measured before and after intravenous urography with an ionic high-osmolal radiocontrast medium, meglumine sodium diatrizoate, or with a non ionic low-osmolal one, iopamidol. Urinary NAG excretion did not change significantly after administration of either contrast media. Urinary AAP and γ-GT excretion increased significantly (p < 0.01) after diatrizoate. After iopamidol, only γ-GT excretion increased significantly (p < 0.05). Our data suggest that the nonionic low-osmolal radiocontrast medium iopamidol is less toxic to tubules than the ionic high-osmolal medium diatrizoate and that the brush-border enzymes AAP and γ-GT are sensitive markers for this toxicity.

show abstract

Section: Discussionmentioning

confidence: 38%

Tubular Nephrotoxicity after Intravenous Urography with Ionic High-Osmolal and Nonionic Low-Osmolal Contrast Media in Patients with Chronic Renal Insufficiency

Cavaliere¹,

Arrigo²,

D’Amico³

et al. 1987

Nephron

View full text Add to dashboard Cite

show abstract

Renal Effects of the Non-Ionic Contrast Medium Iopentol after Intravenous Injection in Healthy Volunteers

Jakobsen¹,

Berg²,

Waaler³

et al. 1990

Acta Radiol

View full text Add to dashboard Cite

Renal effects of the new non-ionic contrast medium iopentol in increasing doses were assessed and compared with the effects of physiologic saline. Twenty-four healthy male volunteers, allocated to three dose groups, were given iopentol intravenously in doses of 0.3, 0.6, and 1.2 g I/kg body weight, respectively. The highest dose group was also given physiologic saline separately as a control. The diuresis increased in all groups, most in the highest dose group, and with a concomitant fall of urine osmolality and increase in osmolar clearance. A slight decrease of serum osmolality, creatinine and urea occurred at 3 hours due to hemodilution. The glomerular filtration rate was unaffected by iopentol. The urinary excretion of albumin and β2-microglobulin was unchanged. However, urinary N-acetyl-β-glucosaminidase and alkaline phosphatase increased significantly, most in the highest dose group. All changes were reversible.

show abstract

Nephrotoxicity of Iodinated Contrast Media: A Preliminary Report on Five Compounds Used for Urography

Cited by 2 publications

References 6 publications

Tubular Nephrotoxicity after Intravenous Urography with Ionic High-Osmolal and Nonionic Low-Osmolal Contrast Media in Patients with Chronic Renal Insufficiency

Tubular Nephrotoxicity after Intravenous Urography with Ionic High-Osmolal and Nonionic Low-Osmolal Contrast Media in Patients with Chronic Renal Insufficiency

Renal Effects of the Non-Ionic Contrast Medium Iopentol after Intravenous Injection in Healthy Volunteers

Contact Info

Product

Resources

About