Nephrotoxicity of nickel nano and microparticles in rat- a comparative, time dependent study with special reference to antioxidant defence system

Singh, Meenu; Verma, Yeshvandra; Rana, S. V. S.

doi:10.1080/24701556.2022.2048307

Cited by 4 publications

(2 citation statements)

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“…It is known that NPs cause damage to the antioxidant defense system by triggering the production of free radicals. 43 , 45 In the current study, CAT, SOD, GPx, and GST activities decreased significantly in NiO and NiONP applied groups compared with the control group. While the most suppression of CAT activity was in NiO IV in NiO groups, it was in NiONP IV in NiONP groups.…”

Section: Discussionsupporting

confidence: 52%

“… 42 It has been shown by studies that NPs disrupt the intracellular oxidant-antioxidant balance, and it is stated that they create cytotoxicity in the cell and damage the protein, lipid, and DNA structure. 43 The presence of oxidative stress, SOD, CAT, GPx, and GST antioxidant enzymes and the level of lipid peroxidation marker MDA have been investigated and shown many times in different tissues. 44 In the current study, the MDA level was statistically higher in the NiO and NiONP applied groups than in the control group.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of nickel oxide nano and microparticles toxicity in rat liver: molecular, biochemical, and histopathological study

Adiguzel,

Karaboduk,

Apaydin

et al. 2023

Toxicology Research

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The unique properties of nickel oxide nanoparticles distinguish it from classical nickel compounds, increasing its use in agriculture, industry, and many industrial areas. The aim of this study is to investigate the possible toxicity of nickel oxide and nickel oxide nanoparticles in the liver. For this purpose, Wistar rats were given nickel oxide and nickel oxide nanoparticles orally, intraperitoneally, and intravenously for 21 days. Liver organ weight, biochemical and hematological parameters, oxidative stress (malondialdehyde, catalase, superoxide dismutase, glutathione peroxidase, and glutathione S transferase), acetylcholinesterase activities, inflammation levels, apoptotic markers, and histopathological changes were evaluated comparatively. When the data obtained were examined in general, it was observed that nickel oxide nanoparticles caused more hepatotoxicity in liver tissue than nickel oxide in terms of oxidative stress parameters, apoptotic markers, inflammation indicators, and other parameters examined. The results suggest that toxicity induced by both nickel oxide and nickel oxide nanoparticles plays an important role in hepatocyte apoptosis.

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Section: Discussionsupporting

confidence: 52%