Neriproct: Its anti-inflammatory effect on an experimentally induced hemorrhoid model in the rat.

Nishiki, Katsuyuki; Kudoh, Daigo; Nishinaga, Kozue; Iwai, Katsumi; Nakagawa, Hidehiko

doi:10.1254/fpj.92.227

Cited by 2 publications

(4 citation statements)

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“…Therapeutic effects of several anti-hemorrhoid drugs were also examined using a hemorrhoid model utilizing abrasive irritation and compared to those resulting from the croton oil model. In one study, microscopic observation showed that destruction of the mucus epithelium, necrosis of the mucus layer, infiltration of inflammatory cells and vasodilatation in the croton oil model were also markedly suppressed by glucocorticoids, including drug application (20). In this study, we observed remarkable improvement of hemorrhoids using our herbal cream.…”

Section: Discussionsupporting

confidence: 53%

“…The application of croton oil to the anal canal can cause tissue inflammation and damage, especially to vessels by increasing their permeability, which leads to leukocyte increment (20). In our study, after croton oil application, animals showed inflammation and damaged areas in the recto-anal canal including damaged tunica mucosa layer and the mucus glands of this layer.…”

Section: Discussionsupporting

confidence: 46%

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Herbal Haemorrhoidal Cream for Haemorrhoids

Gúrel

Üstünova²,

Ergin³

et al. 2013

Chin. J. Physiol.

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Although hemorrhoids are one of the most common diseases in the world, the exact etiology underlying the development of hemorrhoids is not clear. Many different ointments are currently used to treat hemorrhoids; however, there is little evidence of the efficacy of these treatments to support their use. The aim of this study was to compare different herbal creams used for the treatment of hemorrhoids. Twenty-eight male Wistar albino rats, 6-8 weeks old and weighing 160-180 g, were used in this study as 1-control, 2-croton oil, 3-croton oil+fig leaves+artichoke leaves+walnut husks and 4-croton oil+fig leaves+artichoke leaves+walnut husks+horse chestnut fruit. After 3 days of croton oil application, rats were treated with 0.1 ml of cream or saline twice a day for 15 days by syringe. Tissue and blood samples were collected for histological, immunohistochemical and biochemical studies. Statistical significance was determined using one-way ANOVA followed by Tukey's multiple comparison tests. Croton oil administration resulted in severe inflammation. The third group showed partial improvement in inflammation; however, the greatest degree of improvement was seen in the fourth group, and some recovered areas were observed. Myeloperoxidase immunoreactivity was found to be decreased in the third and fourth groups compared to the second group. Additionally, biochemical analyses (Myeloperoxidase, Malondyaldehyde, nitrate/nitrite and nitrotyrosine levels and Superoxide Dismutase activity) were in agreement with the histological and immunohistochemical results. In conclusion, croton oil causes inflammation in the anal area and results in hemorrhoids. Treatment with our herbal hemorrhoid creams demonstrated anti-inflammatory and anti-oxidant effects in this model.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionsupporting

confidence: 46%

Herbal Haemorrhoidal Cream for Haemorrhoids

Gúrel

Üstünova²,

Ergin³

et al. 2013

Chin. J. Physiol.

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“…The protocol was designed to quantify the extent of plasma exudation and to determine the levels of inflammatory cytokines such as TNF- α and IL-6 associated with hemorrhoids. In the second set, the effect of PG, PO, and a combination of both were further confirmed by determining the rectoanal coefficient (RAC), severity score, and the histopathological evaluation [11–16]. …”

Section: Methodsmentioning

confidence: 99%

“…Histological observation of the rectoanal tissue was made to note the appearance of inflammatory cells, congestion, hemorrhage, vasodilatation, and medium to high degrees of necrosis [11, 12]. …”

Section: Methodsmentioning

confidence: 99%

An Improved Experimental Model of Hemorrhoids in Rats: Evaluation of Antihemorrhoidal Activity of an Herbal Formulation

Azeemuddin¹,

Viswanatha²,

Rafiq³

et al. 2014

ISRN Pharmacology

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Objective. To improve the existing experimental model of croton oil-induced hemorrhoids in rats by using Evans Blue (EB) dye extravasation technique. Further, an herbal formulation (Pilex) was evaluated for its antihemorrhoidal activity in this model. Methods. Two sets of experiments were carried out: first to improve the experimental model and to validate the same using Pilex and second to evaluate the effect of Pilex on cytoarchitecture of rectoanal tissue in croton oil-induced hemorrhoids. In both sets, hemorrhoids were induced to all the animals, except normal controls, by applying croton oil via rectoanal region and the effect of Pilex ointment (PO), Pilex granules (PG), and combination of PG and PO was evaluated. In the first set, extravasation of EB dye, TNF-α, IL-6, and rectoanal coefficient (RAC) was determined. In the second set, severity of score, RAC, and histopathology were evaluated. Results. The elevated levels of TNF-α, IL-6, and extravasations of EB dye were decreased with the Pilex treatment. The cytoarchitecture of rectoanal portion of the animals treated with Pilex was near to normal. Conclusion. The improved experimental model of hemorrhoid is useful in quantifying the inflammatory exudates and extent of inflammation. In this improved experimental model Pilex showed antihemorrhoidal activity, which further validates its clinical usage.

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Neriproct: Its anti-inflammatory effect on an experimentally induced hemorrhoid model in the rat.

Cited by 2 publications

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Herbal Haemorrhoidal Cream for Haemorrhoids

Herbal Haemorrhoidal Cream for Haemorrhoids

An Improved Experimental Model of Hemorrhoids in Rats: Evaluation of Antihemorrhoidal Activity of an Herbal Formulation

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