Neritriterpenols A-G, euphane and tirucallane triterpenes from Euphorbia neriifolia L. and their bioactivity

Chang, Stephen S.; Huang, Hung‐Tse; Lin, Yu-Chi; Chao, Chih‐Hua; Liao, Geng-You; Zhang, Lin; Huang, Hui‐Chi; Kuo, Jenny Chun-Ling; Liaw, Chia‐Ching; Tai, Chen-Jei; Kuo, Yao-Haur

doi:10.1016/j.phytochem.2022.113199

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…Approximately 130 different types of triterpenoids have been isolated so far from the various species of Euphorbia. According to reports, tertracyclic triterpenoids are one of the major triterpenoids in the Euphorbia species and were divided into four classes: cycloartanes , lanostane (85)(86)(87)(88)(89)(90)(91)(92)(93)(94), euphane (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39), and tirucallane (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Specifically, 9,19-cyclolanosta...…”

Section: Terpenesmentioning

confidence: 99%

“…• Isopimarane (8)(9)(10)(11)(12), and • ent-atisane (13)(14)(15)(16)(17)(18) Isopimarane Ent-atisane abietane, isopimarane, and ent-atisane exhibit anti-HIV activity Atisine diterpene anti-quorin platelets vis PAR-1…”

Section: Leaves Acetate Extractmentioning

confidence: 99%

“…Six euphanes and seven undescribed triterpenes such as neritriterpenoidal C, neritriterpenols A-B and D-G, along with four known triterpenes were isolated from the ethanolic fraction of the E. neriifolia stem. Structural activity relationship (SAR) studies determined that the presence of an unsaturated group at the end of the side chain C17 on euphane-type triterpenes may be related to the anti-proliferative and anti-inflammatory activities of these compounds [12].…”

Section: Wound Healing Propertymentioning

confidence: 99%

“…A novel ingol diterpene, 3-O-acetyl-8-O-tigloylingol (8), euphonerins A-G (1-7), and seven new cycloartane triterpenes were isolated from the methanolic fraction of E. neriifolia leaves, along with three known flavonols (11)(12)(13), (24R)-cycloartane-3β, 24, 25-triol (10), and 3,12-di-O-acetyl-8-O-tigloylingol (9). The structure of 1-8 compounds was created with the help of spectroscopic analysis.…”

Section: Death Receptor Expression Enhancing Activitymentioning

confidence: 99%

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Euphorbia neriifolia (Indian Spurge Tree): A Plant of Multiple Biological and Pharmacological Activities

et al. 2023

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Although India has a well-established and growing economy surrounding synthetic drug chemistry with an antibiotic base, a large part of the population, especially in forested villages and tribal belts, is relying solely on plant-derived drugs. This is due to a lower number of side effects, low chances of resistance development against pathogenic microorganisms, as well as the diversity and affordability of such drugs. In the Indian subcontinents, Euphorbia neriifolia Linn. (EN) is one of the valuable plants from the big family of Euphorbiaceae, which is usually found in rocky and hilly areas. E. neriifolia was found to be useful in curing tumors, abdominal swelling, bronchial infection, hydrophobia, earache, cough and cold, asthma, leprosy, gonorrhea, spleen enlargement, leucoderma, snake bites, scorpion stings, and causing appetite improvement, etc. Different in vitro and in vivo experimental studies were performed to determine the antioxidant, anti-diabetic, immunomodulatory, anti-inflammatory, anti-arthritic, wound healing, anti-atherosclerosis, radioprotective, anti-anxiety, anti-convulsant, anti-psychotic, anti-thrombotic, dermal irritation, hemolytic, analgesic, anti-fertility, diuretic, anti-microbial, anti-diarrheal, and anti-carcinogenic activities of the various parts of EN. Several bioactive compounds, such as euphol, nerifoliol, taraxerol, euphonerins A–G, lectin, etc., were isolated from E. neriifolia and need to be investigated further for various biological activities (cardiovascular and neuronal diseases). In the pharmaceutical sector, E. neriifolia was selected for the development of new drugs due to its broad pharmacological activities. Therefore, in the present review, distribution, classification, morphological and microscopical description, phytochemical investigation, pharmacological activities, medicinal uses, harmful effects, and their treatment were evaluated, especially against different lifestyle-related diseases.

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