Nerve block with liposomal bupivacaine yields fewer complications and similar pain relief when compared to an interscalene catheter for arthroscopic shoulder surgery: a randomized controlled trial

Wall, Kevin; Elphingstone, Joseph; Paul, Kyle D; Arguello, Alexandra M.; Pandey, Akash; Qureshi, Hamza; McGwin, Gerald; MacBeth, Lisa; Feinstein, Joel; Momaya, Amit; Ponce, Brent A.; Brabston, Eugene W.

doi:10.1016/j.jse.2022.07.030

Journal of Shoulder and Elbow Surgery

2022

DOI: 10.1016/j.jse.2022.07.030

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Nerve block with liposomal bupivacaine yields fewer complications and similar pain relief when compared to an interscalene catheter for arthroscopic shoulder surgery: a randomized controlled trial

Kevin Wall¹,

Joseph Elphingstone²,

Kyle D Paul³

et al.

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Cited by 2 publications

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Novel CO2-encapsulated Pluronic F127 hydrogel for the treatment of Achilles tendon injury

Yu,

Lee,

Hsu

et al. 2023

Sci Rep

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Nonsurgical treatment and surgical repairment of injured Achilles tendons seldom restore the wounded tendon to its original elasticity and stiffness. Therefore, we hypothesized that the surgically repaired Achilles tendon can achieve satisfactory regeneration by applying multi-drug encapsulated hydrogels. In this study, a novel bupivacaine-eluting carbon dioxide-encapsulated Pluronic F127 hydrogel (BC-hydrogel) was developed for the treatment of Achilles tendon injuries. The rheological properties of BC-hydrogel were measured. A high-performance liquid chromatography assay was used to assess the release characteristics of bupivacaine in both in vitro and in vivo settings. Furthermore, the effectiveness of BC-hydrogel in treating torn tendons was examined in a rat model, and histological analyses were conducted. Evidently, the degradable hydrogels continuously eluted bupivacaine for more than 14 days. The animal study results revealed that the BC-hydrogel improved the post-surgery mobility of the animals compared with pristine hydrogels. Histological assay results demonstrated a significant reaction to high vascular endothelial growth factor in the surrounding tissues and expression of collagen I within the repaired tendon. This demonstrates the potential of this novel BC-hydrogel as an effective treatment method for Achilles tendon injuries.

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Novel CO2-encapsulated Pluronic F127 hydrogel for the treatment of Achilles tendon injury

Yu,

Lee,

Hsu

et al. 2023

Sci Rep

View full text Add to dashboard Cite

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Implementation of a nonopioid multimodal analgesia protocol significantly reduces opioids prescribed after total shoulder arthroplasty: a retrospective study

Castle,

Kasto,

Jiang

et al. 2024

Seminars in Arthroplasty: JSES

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Nerve block with liposomal bupivacaine yields fewer complications and similar pain relief when compared to an interscalene catheter for arthroscopic shoulder surgery: a randomized controlled trial

Cited by 2 publications

References 25 publications

Novel CO2-encapsulated Pluronic F127 hydrogel for the treatment of Achilles tendon injury

Novel CO2-encapsulated Pluronic F127 hydrogel for the treatment of Achilles tendon injury

Implementation of a nonopioid multimodal analgesia protocol significantly reduces opioids prescribed after total shoulder arthroplasty: a retrospective study

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