Nerve conduction block using combined thermoelectric cooling and high frequency electrical stimulation

Ackermann, D. Michael; Foldes, Emily; Bhadra, Niloy; Kilgore, Kevin L.

doi:10.1016/j.jneumeth.2010.07.043

Cited by 29 publications

(27 citation statements)

References 16 publications

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“…Furthermore, current thermoelectric Peltier technology (Ackermann et al 2010;Aronov and Fee 2011;Rothman and Yang 2003) also makes it possible to design and develop an implantable device to produce a local temperature change between 15 and 50°C. Heating/cooling a peripheral nerve using Peltier technology (Ackermann et al 2010) requires very different electrode geometry to wrap around the nerve than the electrodes used for heating/cooling brain tissue (Aronov and Fee 2011;Rothman and Yang 2003). However, this challenge can be met by either enclosing the nerve with two Peltier devices or by covering the nerve with a highly thermal conductive metal on a Peltier device.…”

Section: Discussionmentioning

confidence: 99%

Conduction block of mammalian myelinated nerve by local cooling to 15–30°C after a brief heating

Zhang

Lyon

Kadow

et al. 2016

Journal of Neurophysiology

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A, Roppolo JR, de Groat WC, Tai C. Conduction block of mammalian myelinated nerve by local cooling to 15-30°C after a brief heating. J Neurophysiol 115: 1436 -1445, 2016. First published January 6, 2016 doi:10.1152/jn.00954.2015This study aimed at understanding thermal effects on nerve conduction and developing new methods to produce a reversible thermal block of axonal conduction in mammalian myelinated nerves. In 13 cats under ␣-chloralose anesthesia, conduction block of pudendal nerves (n ϭ 20) by cooling (5-30°C) or heating (42-54°C) a small segment (9 mm) of the nerve was monitored by the urethral striated muscle contractions and increases in intraurethral pressure induced by intermittent (5 s on and 20 s off) electrical stimulation (50 Hz, 0.2 ms) of the nerve. Cold block was observed at 5-15°C while heat block occurred at 50 -54°C. A complete cold block up to 10 min was fully reversible, but a complete heat block was only reversible when the heating duration was less than 1.3 Ϯ 0.1 min. A brief (Ͻ1 min) reversible complete heat block at 50 -54°C or 15 min of nonblock mild heating at 46 -48°C significantly increased the cold block temperature to 15-30°C. The effect of heating on cold block fully reversed within ϳ40 min. This study discovered a novel method to block mammalian myelinated nerves at 15-30°C, providing the possibility to develop an implantable device to block axonal conduction and treat many chronic disorders. The effect of heating on cold block is of considerable interest because it raises many basic scientific questions that may help reveal the mechanisms underlying cold or heat block of axonal conduction.

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Section: Discussionmentioning

confidence: 99%

Conduction block of mammalian myelinated nerve by local cooling to 15–30°C after a brief heating

Zhang

Lyon

Kadow

et al. 2016

Journal of Neurophysiology

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“…Also note here that the temperature increase will reduce the AP amplitude [10], but this will not affect the recorded signal because the recording cuff is placed at the part of the nerve which is not affected by the local heating process and Fig.8 below shows how APs amplitude recovers. The mechanism for the transient heat block in the case of global heating and temperature change was proposed by Huxley [2] and further elaborated by Rattay and Aberham [3]. With increase of temperature, change of the gating variables and the ion channel permeability are accelerated (Appendix A, eq.…”

Section: Discussionmentioning

confidence: 99%

“…A number of methods have been proposed for blocking nerve conduction typically based on electrical, chemical and/or thermal methods [3]. As with all types of electrical neural intervention, invasive techniques using intrafascicluar electrodes [4], offer better control and accuracy but ultimately damage the nerve.…”

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A Simulation Study of the Combined Thermoelectric Extracellular Stimulation of the Sciatic Nerve of the Xenopus Laevis: The Localized Transient Heat Block

Mou

Triantis

Woods

et al. 2012

IEEE Trans. Biomed. Eng.

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. A simulation study of the combined thermoelectric extracellular stimulation of the sciatic nerve of the Xenopus laevis: the localized transient heat block. IEEE Transactions on Biomedical Engineering, 59(6), pp. 1758 -1769 . doi: 10.1109 /TBME.2012 This is the accepted version of the paper.This version of the publication may differ from the final published version. 1  Abstract-This paper presents the response of the Xenopus laevis nerve fibers to combinations of electrical (cuff electrodes) and optical (infrared laser, low power sub-5mW) stimulation. Assuming that the main effect of the laser irradiation on the nerve tissue is the localized temperature increase, this paper analyzes and gives new insights into the function of the combined thermoelectric stimulation on both excitation and blocking of the nerve action potentials (AP). The calculations involve a finite-element model (COMSOL) to represent the electrical properties of the nerve and cuff. Electric field distribution along the nerve was computed for the given stimulation current profile and imported into a NEURON model, which was built to simulate the electrical behavior of myelinated nerve fiber under extracellular stimulation. The main result of this study of combined thermoelectric stimulation showed that local temperature increase, for the given electric field, can create a transient block of both the generation and propagation of the APs. Some preliminary experimental data in support of this conclusion are also shown. Permanent

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“…One of the clinical 16 requirements in applying the high-frequency nerve block to suppress chronic pain of peripheral origin is to minimize the initial nerve firing induced by the blocking stimulation. Both cooling and DC current have been investigated in an attempt to block the initial firing caused by the high-frequency stimulation [24] [25]. However these blocking methods could cause significant nerve damage in clinical applications.…”

Section: Discussionmentioning

confidence: 99%

An Implantable Neuroprosthetic Device to Normalize Bladder Function after SCI

Tai¹

2012

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE October 2012 REPORT TYPE Annual rep ort DATES COVERED September 2011-21 September 2012 TITLE AND SUBTITLEAn Implantable Neuroprosthetic Device to Normalize Bladder Function after SCI 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER AUTHOR(S)Changfeng Tai, PhD 5d. PROJECT NUMBER 5e. TASK NUMBER E-Mail: cftai@pitt.edu 5f. WORK UNIT NUMBER PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERUniversity of Pittsburgh Pittsburgh, PA 15213-3320 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S)U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTThe long-term goal of our project is to develop a novel neuroprosthetic device to restore the functions of the urinary bladder for SCI people without further damaging the nervous system. Advanced technologies in electrical and computer engineering will be applied to design the novel neuroprosthetic device. Based on our previous studies, we propose in this project to use pudendal nerve stimulation and blockade to restore both continence and micturition after SCI. Our strategy does not require sacral posterior root rhizotomy, preserves the spinal reflex functions of the bowel and sexual organs, and more importantly provides the opportunity for SCI people to benefit from any advance in neural regeneration and repair techniques in the future.During the last year, we have developed the first implantable stimulator and successfully tested it in both anesthetized animals and awake chronic spinal cord injured animals. Efficient voiding was induced by the implanted stimulator in awake chronic spinal cord injured animals. These results indicated that an implantable stimulator for pudendal nerve stimulation/blockade could be developed for human subjects to restore both continence and micturition functions after SCI. Page 4 SUBJECT TERMS IntroductionThe long-term goal of our project is to develop a novel neuroprost...

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Nerve conduction block using combined thermoelectric cooling and high frequency electrical stimulation

Cited by 29 publications

References 16 publications

Conduction block of mammalian myelinated nerve by local cooling to 15–30°C after a brief heating

Conduction block of mammalian myelinated nerve by local cooling to 15–30°C after a brief heating

A Simulation Study of the Combined Thermoelectric Extracellular Stimulation of the Sciatic Nerve of the Xenopus Laevis: The Localized Transient Heat Block

An Implantable Neuroprosthetic Device to Normalize Bladder Function after SCI

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