Nerve conduction in children suffering Insulin Dependent Diabetes Mellitus

Abstract

The peripheral neuropathy is rather a frequently observed complication in diabetic children. The duration of disease and impaired glycemic control play an important role in the development of neuropathy. The introduction of new methods designed to ensure better glycemic control will reduce the incidence of the complication.

Validity of the Neurological Examination in Diagnosing Diabetic Peripheral Neuropathy

“…This finding corresponds with the results of the more recent studies on NCV in pediatric patients with T1DM (Table 1) [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. The study established the presence of DPN in 15 of 39 patients.…”

“…It is generally accepted to be of multifactorial origin. Quite a large number of studies found that glycemic control (HbA 1c ) and duration of disease correlate to NCV abnormalities [9,[15][16][17][18][19]21,23,25]. Two of the more recent studies [22,24] and two of the older studies [16,17], however, found no significant correlation between HbA 1c and duration of disease and NCV abnormalities.…”

“…In addition, only a few studies have been performed on NCV in diabetic children, and the reported prevalence of DPN varies greatly among different studies (Table 1) [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus

“…This is different from the usual concept that sensory nerves are predominantly affected in type 2 diabetes [24]. Studying 40 children with mean disease duration (4.9 ± 3.2 years) similar to our patients' duration (4.92 ± 3.84 years), Cenesiz et al [18] revealed that 10/40 children complained of neurological symptoms and 11/40 children showed one or more neurological deficits. They reported sensorimotor neuropathy as the most prevalent type followed by motor and the least was sensory neuropathy.…”

“…Diabetic neuropathy is caused by an interaction of the patient's susceptibility, vascular, metabolic, and environmental components. Many studies pointed to the risk factors for diabetic neuropathy, such as poor glycemic control, long duration of diabetes, older age of onset, male gender, height, alcohol use, hypertension, nicotine use, and hyperlipidemia [13, 18–21].…”