Nerve Fibers and Histopathology of Endometriosis-Harboring Peritoneum

Tulandi, Togas; Felemban, Afaf; Chen, Moy Fong

doi:10.1016/s1074-3804(05)60556-7

Cited by 56 publications

(47 citation statements)

References 5 publications

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“…Previous studies comparing peritoneal samples from patients with and without endometriosis did not show differences in the mean nerve score (14). No direct contact was found between nerve fibers and endometriotic lesions, but the closest nerve fibers did tend to be nearer to the endometrial glands in women with pelvic pain than in those without it (11,14).…”

mentioning

confidence: 73%

“…Pain mediators must be able to react with nociceptors to induce pain (23). Peritoneum from patients with and without endometriosis is well innervated and shows no difference in the mean nerve score (14). A direct topographic relationship between peritoneal endometriotic foci and nerve fibers has been rejected (11,14).…”

Section: Discussionmentioning

confidence: 99%

“…No direct contact was found between nerve fibers and endometriotic lesions, but the closest nerve fibers did tend to be nearer to the endometrial glands in women with pelvic pain than in those without it (11,14). This led to the assumption that the presence of nerve fibers in the peritoneum is not related to endometriosis-associated symptoms (11,14). Investigations in a rat model of surgically induced endometriosis recently revealed that ectopic endometrial growth induces its own autonomic and sensory innervation (15).…”

mentioning

confidence: 99%

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Growth-associated protein 43–positive sensory nerve fibers accompanied by immature vessels are located in or near peritoneal endometriotic lesions

Mechsner

Schwarz

Thode

et al. 2007

Fertility and Sterility

102

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mentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Growth-associated protein 43–positive sensory nerve fibers accompanied by immature vessels are located in or near peritoneal endometriotic lesions

Mechsner

Schwarz

Thode

et al. 2007

Fertility and Sterility

102

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“…Several researchers have demonstrated nerve fibers in endometriotic lesions, and several neurotransmitters and other neural proteins such as neurofilament, transforming growth factor b1 (TGF-b1), calcitonin gene-related peptide (CGRP), substance P (SP), and vesicular monoamine transporter (VMAT) immunoreactive nerve fibers have been described in endometriotic lesions (1)(2)(3). We recently demonstrated that sensory, adrenergic, and cholinergic nerve fibers are all present in peritoneal endometriotic lesions in women with endometriosis (4).…”

mentioning

confidence: 99%

Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis

Tokushige

Markham

Russell

et al. 2007

Fertility and Sterility

116

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“…Only two studies, both using human tissue, considered neural involvement in ENDO. One used a neurofilament marker and reported that the distance between nerve fibers and the ectopic endometrial growths tended to be less in women with pelvic pain than in those with no pain (6). Another group used S-100 protein as a marker for nerve fibers to compare samples of deeply infiltrating adenomyotic endometrial growths with other growths.…”

mentioning

confidence: 99%

Innervation of ectopic endometrium in a rat model of endometriosis

Berkley

Dmitrieva

Curtis

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

197

161

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Endometriosis (ENDO) is a disorder in which vascularized growths of endometrial tissue occur outside the uterus. Its symptoms include reduced fertility and severe pelvic pain. Mechanisms that maintain the ectopic growths and evoke symptoms are poorly understood. One factor not yet considered is that the ectopic growths develop their own innervation. Here, we tested the hypothesis that the growths develop both an autonomic and a sensory innervation. We used a rat model of surgically induced ENDO whose growths mimic those in women. Furthermore, similar to women with ENDO, such rats exhibit reduced fertility and increased pelvic nociception. The ENDO was induced by autotransplanting, on mesenteric cascade arteries, small pieces of uterus that formed vascularized cysts. The cysts and healthy uterus were harvested from proestrous rats and immunostained using the pan-neuronal marker PGP9.5 and specific markers for calcitonin gene-related peptide (CGRP) (sensory C and A␦ fibers), substance P (SP) (sensory C and A␦ fibers) and vesicular monoamine transporter (sympathetic fibers). Cysts (like the uterus) were robustly innervated, with many PGP9.5-stained neurites accompanying blood vessels and extending into nearby luminal epithelial layers. CGRP-, SP-, and vesicular monoamine transporter-immunostained neurites also were observed, with CGRP and SP neurites extending the furthest into the cyst lining. These results demonstrate that ectopic endometrial growths develop an autonomic and sensory innervation. This innervation could contribute not only to symptoms associated with ENDO but also to maintenance of the ectopic growths.uterus ͉ fertility ͉ pain ͉ transplant ͉ neuropeptides

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Nerve Fibers and Histopathology of Endometriosis-Harboring Peritoneum

Cited by 56 publications

References 5 publications

Growth-associated protein 43–positive sensory nerve fibers accompanied by immature vessels are located in or near peritoneal endometriotic lesions

Growth-associated protein 43–positive sensory nerve fibers accompanied by immature vessels are located in or near peritoneal endometriotic lesions

Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis

Innervation of ectopic endometrium in a rat model of endometriosis

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