Nerve growth cone migration onto Schwann cells involves the calcium-dependent adhesion molecule, N-cadherin

Letourneau, Paul C.; Shattuck, Terri A.; Roche, Florence K.; Takeichi, Masatoshi; Lemmon, Vance

doi:10.1016/0012-1606(90)90209-2

Cited by 102 publications

(60 citation statements)

References 41 publications

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“…FilopodiaJirst detect a change in EC44 substratum Filopodia have been shown to play an important navigational role for growth cones both in vitro (Kapthammer et al, 1986;Bandtlow et al, 1990;Letoumeau et al, 1990Letoumeau et al, , 1991 and in vivo (Raper et al, 1983;Bastiani et al, 1984;Bentley and Toroian-Raymond, 1986;O'Connor et al, 1990;Letoumeau et al, 1991;Chien et al, 1993). As a growth cone approaches a border, filopodia extend as much as 50 Km, and interact with the alternate ECM molecule (Figs.…”

Section: Discussionmentioning

confidence: 99%

Filopodia initiate choices made by sensory neuron growth cones at laminin/fibronectin borders in vitro

1994

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Localized expression of environmental cues is thought to provide directional information to migrating neuronal growth cones by enhancing or suppressing axon outgrowth over limited regions. To investigate how such a mechanism may function in vivo, we observed growth cones of embryonic chick dorsal root ganglion neurons at a substratum border between the extracellular matrix components laminin and fibronectin in vitro using time-lapse phase-contrast and interference reflection microscopy. We found that patterns of laminin and fibronectin could locally promote or suppress the direction of growth cone migration. While migrating on either laminin or fibronectin, at least 79% of growth cones changed their rate and/or direction of outgrowth upon contact with the alternative substratum, in a manner suggesting that growth cones were selecting one substratum over the other. Complex changes in growth cone behavior were initiated by filopodial contact with the alternate substratum, suggesting that filopodia were providing intracellular signals to the growth cone. Using interference reflection microscopy, we have found that selection of a substratum is independent of the degree of close contact to the substratum. We conclude that spatially localized ECM components can direct axon outgrowth by mechanisms based on intracellular signaling through growth cone filopodia.

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Section: Discussionmentioning

confidence: 99%

Filopodia initiate choices made by sensory neuron growth cones at laminin/fibronectin borders in vitro

1994

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“…Armadillo, also serves as the transducer of the WNT signal/wingless signal (Tepass 1999;Nagafuchi 2001). Cadherins are required to maintain stable adhesion between epithelial cells (Larue et al 1994;Riethmacher et al 1995;Tepass et al 1996;Uemura et al 1996) but can also be used by migrating cells to adhere to a cellular substratum (Letourneau et al 1990;Barami et al 1994;Hazan et al 2000;Li et al 2001). In mutants for both zygotic armadillo and DE-cadherin, innexin2 localization is altered and in kropf mutants, components of adherens junctions are mislocalized (Bauer et al 2004).…”

Section: Introductionmentioning

confidence: 99%

DE-Cadherin, a Core Component of the Adherens Junction Complex Modifies Subcellular Localization of theDrosophilaGap Junction Protein Innexin2

Bauer

Weimbs

Lechner

et al. 2006

Cell Communication & Adhesion

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The Drosophila innexin multigene family of gap junction encoding proteins consists of eight family members whose function in epithelial morphogenesis is mostly unknown. We have recently shown that innexin2 plays a crucial role in the organization of embryonic epithelia. Innexin2 protein accumulates in the epidermis in the apico-lateral membrane domain and colocalizes with core proteins of adherens junctions, such as DE-cadherin and Armadillo, the β-catenin homolog. Innexin2 localization is altered in both armadillo and DE-cadherin mutants Biochemical interaction studies point to a direct interaction of DE-cadherin and Armadillo with innexin2 suggesting a close link between gap junction and adherens junction biogenesis. We have used the Drosophila Schneider cell tissue culture system to further study the interaction of innexin2 with DE-cadherin. Our results provide evidence that DE-cadherin may be a key component to control trafficking, and localization of Innexin2 to the plasma membrane.

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“…N-cadherin, amember of the calcium-dependent cadherin family of adhesion molecules [Takeichi, 19901, is also a potent neurite outgrowth-promoting substrate in culture [Bixby and Zhang, 19901. N-cadherin is expressed by neuronal and nonneuronal cells and may play a role in heterotypic cell-cell interactions [Neugebauer et al, 1988;Drazba and Lemmon, 1990;Letourneau et al, 1990;Takeichi, 19901. Laminin is an ECM molecule present in basement membranes that is an adhesive, growth-promoting substrate for nonneuronal and neuronal cells in culture [Edgar, 1991;Reichardt and Tomaselli, 19911. In this study, cytoskeleta1 elements were examined in growth cones growing on uniform fields of L1, N-cadherin, or laminin or at sharp borders between two of these substrates.…”

Section: Introductionmentioning

confidence: 99%

L1, N-cadherin, and laminin induce distinct distribution patterns of cytoskeletal elements in growth cones

Burden-Gulley

Lemmon

1996

Cell Motil. Cytoskeleton

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Nerve growth cone migration onto Schwann cells involves the calcium-dependent adhesion molecule, N-cadherin

Cited by 102 publications

References 41 publications

Filopodia initiate choices made by sensory neuron growth cones at laminin/fibronectin borders in vitro

Filopodia initiate choices made by sensory neuron growth cones at laminin/fibronectin borders in vitro

DE-Cadherin, a Core Component of the Adherens Junction Complex Modifies Subcellular Localization of theDrosophilaGap Junction Protein Innexin2

L1, N-cadherin, and laminin induce distinct distribution patterns of cytoskeletal elements in growth cones

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