Nerve growth factor.

Levi‐Montalcini, Rita; Angeletti, Pietro U.

doi:10.1152/physrev.1968.48.3.534

Cited by 1,921 publications

(459 citation statements)

References 0 publications

Supporting

Mentioning

439

Contrasting

Unclassified

Order By: Relevance

“…The results (Table 2), from studies of 135 animals, indicate that over a period of [1][2][3][4][5] weeks no significant changes in serum NGF concentrations were detected following submandibular gland removal. However, the NGF concentration increased sigificantly in the serum of sham-operated (but not (Phase contrast photomicrograph, 18-hr incubation at 370; X96.)…”

Section: Resultsmentioning

confidence: 95%

“…It has been appreciated for a long time that the submandibular glands of newborn mice contain very low levels of NGF (1,2). Yet, if NGF has an important role to play in saliva, then it is curious that glands of newborns contain such low levels.…”

Section: Resultsmentioning

confidence: 99%

“…This finding suggests that the salivary gland is an exocrine organ for NGF and that the protein may play a biological role in saliva. For unknown reasons, nerve growth factor (NGF) is present in high concentrations in the submandibular glands of mice (1,2) and in the venom of certain snakes (1,3). The concentration of NGF is much higher in glands of male mice than in glands of female mice or prepubescent mice of either sex (1,2).…”

mentioning

confidence: 99%

“…The concentration of NGF is much higher in glands of male mice than in glands of female mice or prepubescent mice of either sex (1,2). Biologically active NGF can also be detected in mouse blood (1). By using a sensitive radioimmunoassay, Hendry (2) found that the plasma of adult male mice contains 6 times as much NGF as does plasma of adult female mice, and Hendry and Iversen (4) found that sialoadenectomy caused a decrease in circulating levels of the factor.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Nerve growth factor in mouse serum and saliva: role of the submandibular gland.

Murphy¹,

Saide²,

Blanchard³

et al. 1977

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The concept that the salivary gland of the mouse is an endocrine organ for nerve growth factor (NGF) has been reexamined. Serum concentrations of the protein have been measured by radioimmunoassay in male and female mice and in mice from which the submandibular glands were removed. In spite of the fact that the submandibular glands of male mice contained more NGF than did those of female mice, no sex differences in circulating concentrations of the factor were detected. Furthermore, serum concentrations of NGF did not change after submandibular gland removal or after administration of several autonomic agonists. These results indicate that the submandibular glands are not endocrine organs with respect to NGF. On the other hand, extremely high concentrations of the factor are normally secreted in mouse saliva at levels that reflect the sex differences in the amount of NGF present in the glands. This finding suggests that the salivary gland is an exocrine organ for NGF and that the protein may play a biological role in saliva. For unknown reasons, nerve growth factor (NGF) is present in high concentrations in the submandibular glands of mice (1, 2) and in the venom of certain snakes (1, 3). The concentration of NGF is much higher in glands of male mice than in glands of female mice or prepubescent mice of either sex (1, 2). Biologically active NGF can also be detected in mouse blood (1). By using a sensitive radioimmunoassay, Hendry (2) found that the plasma of adult male mice contains 6 times as much NGF as does plasma of adult female mice, and Hendry and Iversen (4) found that sialoadenectomy caused a decrease in circulating levels of the factor. After submandibular gland removal, plasma concentrations of NGF dropped to 15% of control values over a period of 33 days and then returned to normal after an additional 27 days, at which time the sex difference in serum levels was reestablished (4). These findings have given rise to the widely held view that circulating levels of NGF are controlled (at least in part) by the submandibular glands (4,5 mouse serum has been found to be on the order of 10-30 min (5). Consequently, if the submandibular glands are a major source of circulating NGF, we would expect that removal of the glands would cause a rapid decrease in serum levels of the protein. However, Hendry and Iversen (4) found that this did not occur.In the present study, we reexamined the role that the submandibular glands might play in secreting NGF into the circulation. In contrast to the results of Hendry and Iversen (4), we found that removal of the submandibular glands has no effect on circulating levels of NGF over a period of 1-5 weeks after sialoadenectomy. Furthermore, serum levels of the factor in adult male and female mice were indistinguishable and did not reflect the sex differences found in salivary gland levels of the protein. Consequently, we conclude that the submandibular gland in the mouse does not function as an endocrine organ for NGF.These results then led to the idea that the salivar...

show abstract

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Nerve growth factor in mouse serum and saliva: role of the submandibular gland.

Murphy¹,

Saide²,

Blanchard³

et al. 1977

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…The discovery of NGF Nerve growth factor (NGF) was discovered in the 1950s (1,2) and represents the first isolated and best characterized member of a growing family of neurotrophins, which includes brain-derived neurotrophic factor and neurotrophins 3-5 (3). Tlie tertii "NGF" was introduced about 40 years ago to describe ati effect on the developing sensory atid sytupathetic neurons of birds and matnnials (1).…”

mentioning

confidence: 99%

The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases

Aloe

Bracci-Laudiero

Бонини

et al. 1997

Allergy

204

127

View full text Add to dashboard Cite

Numerous studies published in the last 10–15 years have shown that nerve growth factor (NGF), a polypeptide originally discovered in connection with its neurotrophic activity, also acts on cells of the immune system. NGF has been found in various immune organs including the spleen, lymph nodes, and thymus, and cells such as mast cells, eosinophils, and B and T cells. The circulating levels of NGF increase in inflammatory responses, in various autoimmune diseases, in parasitic infections, and in allergic diseases. Stress‐related events both in animal models and in man also result in an increase of NGF, suggesting that this molecule is involved in neuroendocrine functions. The rapid release of NGF is part of an alerting signal in response to either psychologically stressful or anxiogenic conditions in response to homeostatic alteration. Thus, the inflammation and stress‐induced increase in NGF might alone or in association with other biologic mediators induce the activation of immune cells during immunologic insults. A clearer understanding of the role of NGF in these events may be useful to identify the mechanisms implicated in certain neuroimmune and immune dysfunctions.

show abstract

Increased Serum Levels of Nerve Growth Factor in von Recklinghausen's Disease

Fabricant¹,

Todaro²

1981

Archives of Neurology

View full text Add to dashboard Cite

Nerve growth factor.

Cited by 1,921 publications

References 0 publications

Nerve growth factor in mouse serum and saliva: role of the submandibular gland.

Nerve growth factor in mouse serum and saliva: role of the submandibular gland.

The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases

Increased Serum Levels of Nerve Growth Factor in von Recklinghausen's Disease

Contact Info

Product

Resources

About