Nerve Growth Factor as a Signaling Molecule for Nerve Cells and also for the Neuroendocrine-Immune Systems

Fiore, M.; Chaldakov, George N.; Aloe, Luigi

doi:10.1515/revneuro.2009.20.2.133

Cited by 121 publications

(98 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As for NGF our findings indicate a serum NGF potentiation during the first week of withdrawal, data in line with a previously published observation showing elevated NGF levels in human plasma during alcohol withdrawal [28]. Indeed, authors discussed that withdrawal from chronic alcohol consumption may elicit significant stress and related anxiety triggering NGF blood release as previously observed for other stressing conditions [11,17]. However, other data showed lowered NGF levels in alcohol-dependent patients [26,49,50].…”

Section: Discussionsupporting

confidence: 91%

“…Although the mechanisms having a role in chronic alcohol treatment-induced neurotoxic actions have not yet been clearly identified, different investigations have hypothesized that alcohol intake (i.e. acute, chronic, during gestation, paternal [1,2,9,10]) may disrupt the synthesis of neurotrophins, which are a proteins' family playing a crucial role in cognitive function, including the processes of learning and memory [11,12]. Neurotrophins are particularly important in many aspects of brain cells' development, nutrition, growth and survival [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal

Carito¹

2015

J Alcohol Drug Depend

View full text Add to dashboard Cite

Many studies have suggested possible relationships between the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) and alcohol addiction. Previous reports demonstrated severe changes in these neurotrophins in the serum of alcohol dependent patients and during withdrawal. Alcohol dependence syndromes during consumption and/or withdrawal are also characterized by elevated oxidative stress. Polyphenols, including olive polyphenols, are natural compounds known to possess marked antioxidant properties. Thus, this study was carried out in order to verify the effects of a blend of olive polyphenols supplementation containing mostly hydroxytyrosol (50 mg/day for 15 consecutive days) in alcoholic men during withdrawal on serum BDNF and NGF. As controls a group of alcohol dependent patients received sucrose tablets as placebo. BDNF and NGF were measured by ELISA on day 1, 3, 7 and 15 of the detoxification period. Some parameters of oxidative stress were analyzed too as free oxygen radicals defense (FORD) and free oxygen radicals test (FORT). No differences in oxidative status due to polyphenols were found. However, withdrawal elicited a mild increase in BDNF over two weeks that was counteracted on day 3 by polyphenols. As for NGF no effects of polyphenols supplementation were discovered to antagonize the expected NGF serum elevation during withdrawal. In conclusion the present data may indicate that monitoring serum BDNF and/or NGF in alcoholics undergoing detoxification could contribute to characterize alcohol dependence profiles to improve recovery processes throughout also antioxidant compounds.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal

Carito¹

2015

J Alcohol Drug Depend

View full text Add to dashboard Cite

show abstract

“…Within the peripheral nervous system TrkA regulates the formation, differentiation and survival of sympathetic neurones that originate from progenitors of neural crest origin (Bibel & Barde, 2000;Kaplan & Miller, 2000;Oppenheim, 1991;Ernsberger, 2009). TrkA is also critical for the development and function of the immune system (Vega et al, 2003;Fiore et al, 2009). …”

Section: The Trka Proto-oncogenementioning

confidence: 99%

Alternative TrkA Splicing and Neuroblastoma

Farina¹,

Cappabianca²,

Ruggeri³

et al. 2012

Neuroblastoma - Present and Future

View full text Add to dashboard Cite

“…4B). MMC-treated NSCs expressed a few neuronal molecules such as cholinergic receptors and molecules previously shown to be involved in neuronal differentiation (NGF) (11,16,61) and survival (IGF-1) (29).…”

Section: R732mentioning

confidence: 99%

Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro

Felfly¹,

Xue²,

Zambon³

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Stem cells are a potential key strategy for treating neurodegenerative diseases in which the generation of new neurons is critical. A better understanding of the characteristics and molecular properties of neural stem cells (NSCs) and differentiated neurons can help with assessing neuronal maturity and, possibly, in devising better therapeutic strategies. We have performed an in-depth gene expression profiling study of murine NSCs and primary neurons derived from embryonic mouse brains. Microarray analysis revealed a neuron-specific gene expression signature that distinguishes primary neurons from NSCs, with elevated levels of transcripts involved in neuronal functions, such as neurite development and axon guidance in primary neurons and decreased levels of multiple cytokine transcripts. Among the differentially expressed genes, we found a statistically significant enrichment of genes in the ephrin, neurotrophin, CDK5, and actin pathways, which control multiple neuronal-specific functions. We then artificially blocked the cell cycle of NSCs with mitomycin C (MMC) and examined cellular morphology and gene expression signatures. Although these MMCtreated NSCs displayed a neuronal morphology and expressed some neuronal differentiation marker genes, their gene expression patterns were very different from primary neurons. We conclude that 1) fully differentiated mouse primary neurons display a specific neuronal gene expression signature; 2) cell cycle block at the S phase in NSCs with MMC does not induce the formation of fully differentiated neurons; 3) cytokines change their expression pattern during differentiation of NSCs into neurons; and 4) signaling pathways of ephrin, neurotrophin, CDK5, and actin, related to major neuronal features, are dynamically enriched in genes showing changes in expression level. neural stem cell; primary neuron; cell cycle block NEURAL STEM CELLS (NSCs) exist in various regions of the central nervous system throughout the life span in mammals (7,21,26,31,46). For example, the subventricular zone and subgranular zone of the hippocampus contain a relatively high density of NSCs. These areas are considered neurogenic since they continue to produce neurons throughout adult life, in contrast to other brain regions where neurogenesis is not observed in the adult (20,25,62). The division and differentiation of these endogenous NSCs can be regulated by both physiological stimuli and pathological conditions (4, 28).To better understand NSC biology, various cell lines were derived (2,13,19,30,34,35,40,45). NSC lines were typically screened for the presence of NSC markers and subsequently used for a variety of applications such as 1) transplantations for the purpose of alleviating brain damage after certain diseases, 2) their ability to promote neuronal survival and neurite outgrowth, and 3) the secretion of a variety of growth factors (9, 30, 34 -36, 38, 40, 43, 48, 50, 51, 53, 56, 58).Furthermore, to better understand NSC biology and the response of these cells to different conditions, which c...

show abstract

Nerve Growth Factor as a Signaling Molecule for Nerve Cells and also for the Neuroendocrine-Immune Systems

Cited by 121 publications

References 112 publications

Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal

Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal

Alternative TrkA Splicing and Neuroblastoma

Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro

Contact Info

Product

Resources

About