Nerve growth factor-carbon nanotube complex exerts prolonged protective effects in an in vitro model of ischemic stroke

Hassanzadeh, Parichehr; Arbabi, Elham; Atyabi, Fatemeh; Dinarvand, Rassoul

doi:10.1016/j.lfs.2016.11.029

Cited by 48 publications

(17 citation statements)

References 49 publications

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“…Физиологические данные показывают, что нейропротективными и нейрорегенеративными свойствами обладает NGF. NGF эффективно противодействует глутаматной токсичности [15], участвует в защите клеток от окислительного стресса, стимулируя экспрессию белковантиоксидантов, например белка теплового шока HSP32 (гемоксигеназа 1), супероксиддисмутазы и глутатионпероксидазы [16], проявляет выраженную антиапоптотическую активность, снижая экспрессию проапоптотических белков, таких как Bax и каспаза-3, и стимулируя экспрессию антиапоптотических белков, таких как Bcl-2 [6,17]. Кроме того, NGF участвует в стимуляции нейрогенеза [18], в том числе в условиях экспериментальной церебральной ишемии [4] и стимулирует ангиогенез [19].…”

Section: Discussionunclassified

An experimental evaluation of the therapeutic window of the neuroprotective activity of a low-molecular nerve growth factor mimetic GK-2

Sb¹,

Py²,

Gudasheva³

2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Section: Discussionunclassified

An experimental evaluation of the therapeutic window of the neuroprotective activity of a low-molecular nerve growth factor mimetic GK-2

Sb¹,

Py²,

Gudasheva³

2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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“…A variety of nanoplatforms such as mesoporous silica or gold NPs and nanoblades could be applied for viral genome editing [ 121 ]. CNTs with extensive potentials for targeted delivery of various theranostics, could be used as nanocarriers of the antiviral agents and increase their efficiency [ [122] , [123] , [124] , [125] , [126] ]. Chemical linkage of isoprinosine or ribavirin on the single-walled CNT surface has provided improved efficiency of drugs [ 127 , 128 ].…”

Section: Nanomaterials Against the Covid-19mentioning

confidence: 99%

Nanotheranostics against COVID-19: From multivalent to immune-targeted materials

Hassanzadeh

2020

Journal of Controlled Release

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Destructive impacts of COVID-19 pandemic worldwide necessitates taking more appropriate measures for mitigating virus spread and development of the effective theranostic agents. In general, high heterogeneity of viruses is a major challenging issue towards the development of effective antiviral agents. Regarding the coronavirus, its high mutation rates can negatively affect virus detection process or the efficiency of drugs and vaccines in development or induce drug resistance. Bioengineered nanomaterials with suitable physicochemical characteristics for site-specific therapeutic delivery, highly-sensitive nanobiosensors for detection of very low virus concentration, and real-time protections using the nanorobots can provide roadmaps towards the imminent breakthroughs in theranostics of a variety of diseases including the COVID-19. Besides revolutionizing the classical disinfection procedures, state-of-the-art nanotechnology-based approaches enable providing the analytical tools for accelerated monitoring of coronavirus and associated biomarkers or drug delivery towards the pulmonary system or other affected organs. Multivalent nanomaterials capable of interaction with multivalent pathogens including the viruses could be suitable candidates for viral detection and prevention of further infections. Besides the inactivation or destruction of the virus, functionalized nanoparticles capable of modulating patient’s immune response might be of great significance for attenuating the exaggerated inflammatory reactions or development of the effective nanovaccines and medications against the virus pandemics including the COVID-19.

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“…Nanotechnology along with tissue engineering are promising approaches for designing the controlled release systems containing the bioactive proteins or a variety of drugs which may re-establish the functional neuronal networks or neuronal connectivity (9)(10)(11). Carbon nanotubes (CNTs) with superior mechanical properties, improved biocompatibility, and high thermo-electrical conductivities, have shown enormous for biosensing, non-invasive and high-resolution imaging, CNTs may be applied as the carriers of therapeutics against a variety of disorders (12)(13)(14)(15)(16)(17)(18). Early detection of neoplastic or precancerous lesions has remained challenging that may be imaging technologies for early detection.…”

Section: R E V I E Wmentioning

confidence: 99%

Nanoparticles reshape the biomedical industry

2018

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Over the last decades, increasing interest has been attracted towards the nanotechnology which provide a set of promising research tools and theranostic approaches. Tremendous research efforts in nanofabrication technology have led to the production or drugs against the metabolism or excretion. Furthermore, controlled delivery and targeted therapy may result in the improved materials capable of interaction with the nervous systems, and nanopharmaceuticals with minimal toxicity and improved biohas been highlighted.

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Nerve growth factor-carbon nanotube complex exerts prolonged protective effects in an in vitro model of ischemic stroke

Cited by 48 publications

References 49 publications

An experimental evaluation of the therapeutic window of the neuroprotective activity of a low-molecular nerve growth factor mimetic GK-2

An experimental evaluation of the therapeutic window of the neuroprotective activity of a low-molecular nerve growth factor mimetic GK-2

Nanotheranostics against COVID-19: From multivalent to immune-targeted materials

Nanoparticles reshape the biomedical industry

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