Nerve Growth Factor of Red Nucleus Involvement in Pain Induced by Spared Nerve Injury of the Rat Sciatic Nerve

Jing, Yuanyuan; Wang, Jun-Yang; Li, Xiaoli; Wang, Zhihong; Liu, Pei; Pan, Mingming; Dong, Xiao-Ping; Fan, Gui-Xiang; Yuan, Yukang

doi:10.1007/s11064-009-9950-7

Cited by 30 publications

(13 citation statements)

References 25 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neurotrophins have been implicated in neuropathic pain, particularly brain-derived neurotrophic factor 15 and nerve growth factor. 16 In our study, about half of the subjects had severe neuropathic pain (VAS scores 450/100). To our surprise, the 6-week course of oral lithium carbonate treatment markedly reduced VAS scores, not only at the end of the 6-week treatment period but also at the 6 months follow-up examination, 4 and a half months after the lithium was stopped.…”

Section: Discussionmentioning

confidence: 51%

Efficacy and safety of lithium carbonate treatment of chronic spinal cord injuries: a double-blind, randomized, placebo-controlled clinical trial

Yang

et al. 2011

Spinal Cord

View full text Add to dashboard Cite

Study design: Lithium has attracted much attention as a neuroregenerative agent for spinal cord injury in animal models. We hypothesized that the lithium can be beneficial to patients with spinal cord injury. The safety and pharmacokinetics of lithium has been studied in our earlier phase I clinical trial, indicating its safety. This is a phase II clinical trial to evaluate its efficacy on chronic spinal cord injury patients. Objectives: The aim of this study was to investigate the efficacy of lithium on chronic spinal cord injury patients. Setting: A major spinal cord injury rehabilitation center in Beijing, China. Methods: Randomized, double-blind, placebo-controlled 6-week parallel treatment arms with lithium carbonate and with placebo. A total of 40 chronic spinal cord injury subjects were recruited. Oral lithium carbonate was titrated or placebo was simulated to maintain the serum lithium level of 0.6-1.2 mmol l À1 for 6 weeks, followed by a 6-month follow-up. The functional outcomes and the neurological classifications, as well as the safety parameters, adverse events and pharmacokinetic data were carefully collected and monitored. Results: No significant changes in the functional outcomes and the neurological classifications were found. The only significant differences were in the pain assessments using visual analog scale comparing the lithium and the placebo group. No severe adverse event was documented in the study. Conclusion: The lithium treatment did not change the neurological outcomes of patients with chronic spinal cord injury. It is worth to investigate whether lithium is effective in the treatment of neuropathic pain in chronic spinal cord injury. Sponsorship: China Spinal Cord Injury Network Company Limited.

show abstract

Section: Discussionmentioning

confidence: 51%

Efficacy and safety of lithium carbonate treatment of chronic spinal cord injuries: a double-blind, randomized, placebo-controlled clinical trial

Yang

et al. 2011

Spinal Cord

View full text Add to dashboard Cite

show abstract

“…21 In addition, elevated levels of nerve growth factor in the red nucleus has been associated with development of neuropathic pain following peripheral nerve injury in rats. 22 Thus, an alteration in the coordination between the cerebellum and motor cortex involving the red nucleus may have consequences for bladder function and pain. Even though cerebellar activation has often been observed in evoked brain responses to experimental pain stimuli, its specific role in pain processing/modulation remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Alterations in Resting State Oscillations and Connectivity in Sensory and Motor Networks in Women with Interstitial Cystitis/Painful Bladder Syndrome

et al. 2014

View full text Add to dashboard Cite

Purpose The pathophysiology of interstitial cystitis/painful bladder syndrome (IC/PBS) remains incompletely understood, but is thought to involve a central disturbance in the processing of pain and viscerosensory signals. We aimed to identify differences in brain activity and connectivity between female IC/PBS patients and healthy controls in order to advance clinical phenotyping and treatment efforts for IC/PBS. Materials and Methods We examined oscillation dynamics of intrinsic brain activity in a large sample of well-phenotyped female IC/PBS patients and female healthy controls collected during a 10-minute resting fMRI scan as part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network* project. The BOLD signal was transformed to the frequency domain and relative power was computed for multiple frequency bands. Results The results demonstrated altered frequency distributions in a viscerosensory region (post Insula) and sensorimotor cortices (postcentral gyrus, paracentral lobule, supplementary motor area (SMA), including a region likely involved in control of pelvic floor muscles (PelMotor). Additionally, the SMA, paracentral lobule and PelMotor all demonstrated increased functional connectivity to the midbrain (red nucleus) and cerebellum. This increased functional connectivity was greatest in patients reporting pain during bladder filling. Conclusions These findings suggest that women with IC/PBS have a neuromotor component to their pathology involving an alteration in the intrinsic oscillations and connectivity within a cortico-cerebellar network previously associated with urinary bladder function.

show abstract

“…As part of the www.futuremedicine.com descending motor system, the RN is not typically considered to have an important role in pain processing, but a number of studies suggest otherwise [9]. RN stimulation leads to increases in the pain threshold (an antinocioceptive effect) and this seems to be under upstream control by the nucleus raphe magnus.…”

Section: Red Nucleusmentioning

confidence: 99%

The Neurobiology of Pain Perception in Normal and Persistent Pain

2015

View full text Add to dashboard Cite

Pain is a significant national burden in terms of patient suffering, expenditure and lost productivity. Understanding pain is fundamental to improving evaluation, treatment and innovation in the management of acute and persistent pain syndromes. Pain perception begins in the periphery, and then ascends in several tracts, relaying at different levels. Pain signals arrive in the thalamus and midbrain structures which form the pain neuromatrix, a constantly shifting set of networks and connections that determine conscious perception. Several cortical regions become active simultaneously during pain perception; activity in the cortical pain matrix evolves over time to produce a complex pain perception network. Dysfunction at any level has the potential to produce unregulated, persistent pain.

show abstract

Nerve Growth Factor of Red Nucleus Involvement in Pain Induced by Spared Nerve Injury of the Rat Sciatic Nerve

Cited by 30 publications

References 25 publications

Efficacy and safety of lithium carbonate treatment of chronic spinal cord injuries: a double-blind, randomized, placebo-controlled clinical trial

Efficacy and safety of lithium carbonate treatment of chronic spinal cord injuries: a double-blind, randomized, placebo-controlled clinical trial

Alterations in Resting State Oscillations and Connectivity in Sensory and Motor Networks in Women with Interstitial Cystitis/Painful Bladder Syndrome

The Neurobiology of Pain Perception in Normal and Persistent Pain

Contact Info

Product

Resources

About