Nerve growth factor receptor (p75<sup>NTR</sup>) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma

Søland, Tine M.; Brusevold, Ingvild J.; Koppang, Hanna Strömme; Schenck, Karl; Bryne, Magne

doi:10.1111/j.1365-2559.2008.03063.x

Cited by 41 publications

(46 citation statements)

References 39 publications

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“…This finding was in accordance with those of previous studies [25][26][27] , but no relationships between mode of invasion and MCD, VEGF, and COX-2 expression were found. Mode of invasion is a histologic parameter characterized by the number of tumor cells in islands, the borders and shapes of tumor islands, and the growth patterns.…”

Section: Discussionsupporting

confidence: 83%

Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma

2016

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Background: Overexpression of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) and increasing mast cell density (MCD) in premalignant and malignant oral lesions have been documented. However, their correlation with clinicopathologic parameters and survival rate in oral squamous cell carcinoma (OSCC) is not completely clear. This study aimed to assess these subjects. Methods: VEGF, COX-2, and mast cell tryptase expression were examined immunohistochemically in 57 cases of OSCC. The relationships between the markers' expression and clinicopathologic data were assessed using bivariate and multivariate analysis. Results: Spearman's rank correlation coefficient showed a significant correlation between VEGF and COX-2 expression (r = 0.462, p < 0.001),as well as between VEGF expression and MCD (r = 0.306, p < 0.001). Multivariate analysis showed no significant correlation between the markers' immunoexpression and overall survival (OS), but a significant correlation between mode of invasion and OS [hazard ratio 0.362 (95% CI: 0.138- 0.974); p = 0.038] was observed. An association between MCD and gender (p = 0.042) was also found, as MCD was higher in males. Conclusion: The significant correlation of VEGF expression with COX-2 expression and MCD may represent the roles of COX-2 and MCD in tumor angiogenesis by modulating VEGF production. However, VEGF, COX-2, and MCD are not useful indicators to predict prognosis in OSCC. Nevertheless, the mode of invasion can be considered as an independent prognostic factor in OSCC patients.

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Section: Discussionsupporting

confidence: 83%

Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma

2016

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“…However, overexpression of p75 NTR is associated with advanced stage of melanoma progression and enhanced invasive potential of the melanoma cells [16]. In oral cancer, expression of p75 NTR is found to be related to poor prognosis of the tumor and the most important independent predictor is p75 NTR -positive cells at the invasive front (>10%) [8]. Out of our expectation, we found in the present investigation that expression level of p75 NTR in human LSCC was associated with none of the parameters listed, which is consistent with the findings by Søland et al in oral cancers [8].…”

Section: Discussionmentioning

confidence: 98%

“…In oral cancer, expression of p75 NTR is found to be related to poor prognosis of the tumor and the most important independent predictor is p75 NTR -positive cells at the invasive front (>10%) [8]. Out of our expectation, we found in the present investigation that expression level of p75 NTR in human LSCC was associated with none of the parameters listed, which is consistent with the findings by Søland et al in oral cancers [8]. This clearly demonstrates that the functions of p75 NTR in laryngeal carcinoma need further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…In esophageal squamous cell carcinoma, a small percentage of p75 NTR -positive cancer cells with high proliferative potential are believed to be cancer stem cells (CSCs) [6]. Moreover, the expression of p75 NTR is associated with biological behaviors and prognosis of some cancers such as carcinoma of the esophagus and oral cavity, as reported in some recent investigations [7,8]. All these findings reveal the diversity and complexity of biological functions of this receptor protein in both physiological and pathological processes.…”

Section: Introductionmentioning

confidence: 86%

“…without any prior knowledge of each patient's clinical information. We referred to the Søland (2008) method [8] to set up score standards and we considered cell membrane or cytoplasm coloration all to be positive staining. Within the deepest part of the tumor, the cancer cells that were closest (one to two tumor cell layers) to the connective tissue were defined as the tumor invasive front.…”

Section: Evaluation Of Immunohistochemistrymentioning

confidence: 99%

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Biological and clinical significance of p75^NTRexpression in laryngeal squamous epithelia and laryngocarcinoma

Li¹,

Di²,

Li³

et al. 2011

Acta Oto-Laryngologica

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The expression of p75(NTR) was only located in basal cells of normal laryngeal epithelia, consistent with the staining features of epithelial stem cells as evidenced by parallel staining of p63, a putative keratinocyte stem cell marker. p75(NTR) is differentially expressed in LSCC, although no significant relationship was found with many clinicopathologic factors, this expression and distribution may correlate to malignant transformation and tumor proliferation. Co-expression of p75(NTR) and CD133 was confirmed, showing the association of p75(NTR)-positive cells with cancer stem cells in Hep-2 cells.

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BEX3 contributes to cisplatin chemoresistance in nasopharyngeal carcinoma

Gao

Chen

et al. 2017

Cancer Medicine

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Nasopharyngeal carcinoma (NPC) can develop cisplatin‐resistant phenotype. Research has revealed that enriched in cancer stem cell population is involved in developing cisplatin‐resistant phenotype. CD271 is a candidate stem cell maker in head and neck cancers. The CD receptor does not possess any enzymatic property. Signal transduction function of CD271 is mediated by the cellular receptor‐associated protein. Our data showed that Brain‐expressed X‐linked 3 (BEX3), a CD271 receptor‐associated protein, was overexpressed in NPC. BEX3 overexpression was a unique event in cancer developed in the head and neck regions, especially NPC. BEX3 expression was inducible by cisplatin in NPC. In cisplatin‐resistant NPC xenograft, treatment with nontoxic level of cisplatin led to a remarkable increase in BEX3 level. High BEX3 expression was accompanied with high octamer‐binding transcription factor 4 (OCT4) expression in cisplatin‐resistant NPC. To confirm the inducing role of BEX3 on OCT4 expression, we knockdown BEX3 using siRNA and compared the expression of OCT4 with mock transfectants. Suppressing BEX3 transcripts led to a significant reduction in OCT4. In addition, targeting BEX3 using shRNA could increase the sensitivity of NPC cells to cisplatin. In summary, our results indicated a unique functional role of BEX3 in mediating the sensitivity of NPC cells to cisplatin. Targeting or blocking BEX3 activity might be useful in reversing the cisplatin‐resistant phenotype in NPC.

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Nerve growth factor receptor (p75^NTR) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma

Cited by 41 publications

References 39 publications

Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma

Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma

Biological and clinical significance of p75^NTRexpression in laryngeal squamous epithelia and laryngocarcinoma

BEX3 contributes to cisplatin chemoresistance in nasopharyngeal carcinoma

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Nerve growth factor receptor (p75NTR) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma

Cited by 41 publications

References 39 publications

Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma

Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma

Biological and clinical significance of p75NTRexpression in laryngeal squamous epithelia and laryngocarcinoma

BEX3 contributes to cisplatin chemoresistance in nasopharyngeal carcinoma

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Nerve growth factor receptor (p75^NTR) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma

Biological and clinical significance of p75^NTRexpression in laryngeal squamous epithelia and laryngocarcinoma