Nerve implants with bioactive interfaces enhance neurite outgrowth and nerve regeneration in vivo

An electrical microenvironment constructed based on electromagnetic induction stimulates neural differentiation

“…55 By analyzing neurite outgrowth, it could be found that cells on all groups had neurite, and the cells cultured in NH 2 -MXene/PLLA under a rotating magnetic field possessed the longest neurite, indicating its excellent differentiation performance. 56 The percentage and neurite length of differentiated PC12 were determined from optical images. The percentages of sympathetic neuron-like cells with neurites in the NH 2 -MXene/PLLA groups significantly increased under the same conditions, in comparison with that of the other two groups (Fig.…”

An osteoinductive surface by adhesive bone morphogenetic protein-2 prepared using the bioorthogonal approach for tight binding of titanium with bone

“…[29][30][31] Therefore, a peptide containing both DOPA and lysine was incorporated into several polypeptides, which were then used as active forms of monomers for preparing growth factors capable of adhering to inorganic or organic materials. [32][33][34][35][36][37] However, dimer formation is essential for BMP-2 to exhibit its biological activity. 10,11,38 Although various approaches have been tested, the process of preparing biologically active BMP-2 dimers remains challenging.…”