Nerve Injury Decreases Hyperacute Resting-State Connectivity Between the Anterior Cingulate and Primary Somatosensory Cortex in Anesthetized Rats

Tøttrup, Lea; Atashzar, S. Farokh; Farina, Dario; Kamavuako, Ernest Nlandu; Jensen, Winnie

doi:10.1109/tnsre.2020.3039854

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…The selected regions are based on the literature on pain processing ( Figure 1B ). The source activity in these ROI’s were calculated by averaging the current density value of all voxels within the ROI, and computed for eight predefined frequency bands [delta: 0.5–4 Hz, theta: 4–8 Hz, alpha: 8–13 Hz, beta: 14–40 Hz, gamma: 40–49 Hz, high gamma: 51–90 Hz and 0.5–90 Hz ( Tottrup et al, 2020 ; Zarei et al, 2022 )].…”

Section: Methodsmentioning

confidence: 99%

From pulse width modulated TENS to cortical modulation: based on EEG functional connectivity analysis

et al. 2023

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Modulation in the temporal pattern of transcutaneous electrical nerve stimulation (TENS), such as Pulse width modulated (PWM), has been considered a new dimension in pain and neurorehabilitation therapy. Recently, the potentials of PWM TENS have been studied on sensory profiles and corticospinal activity. However, the underlying mechanism of PWM TENS on cortical network which might lead to pain alleviation is not yet investigated. Therefore, we recorded cortical activity using electroencephalography (EEG) from 12 healthy subjects and assessed the alternation of the functional connectivity at the cortex level up to an hour following the PWM TENS and compared that with the effect of conventional TENS. The connectivity between eight brain regions involved in sensory and pain processing was calculated based on phase lag index and spearman correlation. The alteration in segregation and integration of information in the network were investigated using graph theory. The proposed analysis discovered several statistically significant network changes between PWM TENS and conventional TENS, such as increased local strength and efficiency of the network in high gamma-band in primary and secondary somatosensory sources one hour following stimulation. Our findings regarding the long-lasting desired effects of PWM TENS support its potential as a therapeutic intervention in clinical research.

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Section: Methodsmentioning

confidence: 99%

From pulse width modulated TENS to cortical modulation: based on EEG functional connectivity analysis

et al. 2023

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“…All the data from selected sources were first filtered into six predefined frequency bands (δ: 0.5-4 Hz θ: 4-8 Hz, α: 8-13 Hz, β: 14-40 Hz, γ: 51-90 Hz and 0.5-90 Hz [37]) using a 2nd order Butterworth filter. The phase from a time-series signal was obtained by the Hilbert transform.…”

Section: Functional Connectivitymentioning

confidence: 99%

Gamma-band enhancement of functional brain connectivity following transcutaneous electrical nerve stimulation

et al. 2022

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Objective: Transcutaneous electrical nerve stimulation (TENS) has been suggested as a possible non-invasive pain treatment. However, the underlying mechanism of the analgesic effect of TENS and how brain network functional connectivity is affected following the use of TENS is not yet fully understood. The purpose of this study was to investigate the effect of high-frequency TENS on the alternation of functional brain network connectivity and the corresponding topographical changes, besides perceived sensations. Approach: Forty healthy subjects participated in this study. EEG data and sensory profiles were recorded before and up to an hour following high-frequency TENS (100 Hz) in sham and intervention groups. Brain source activity from EEG data was estimated using the LORETA algorithm. In order to generate the brain connectivity network, the Phase lag index was calculated for all pair-wise connections of eight selected brain areas over six different frequency bands (i.e., δ, θ, α, β, γ, and 0.5-90 Hz). Main results: The results suggested that the functional connectivity between the primary somatosensory cortex (SI) and the anterior cingulate cortex (ACC), in addition to functional connectivity between S1 and the medial prefrontal cortex (mPFC), were significantly increased in the gamma-band, following the TENS intervention. Additionally, using graph theory, several significant changes were observed in global and local characteristics of functional brain connectivity in gamma-band. Significance: Our observations in this paper open a neuropsychological window of understanding the underlying mechanism of TENS and the corresponding changes in functional brain connectivity, simultaneously with alternation in sensory perception.

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“…Analyzing the functional brain connectivity in different frequency band have been reported previously (Tøttrup et al 2020). The source activities were further filtered in six classic frequency bands Hz, and 0.5-90 Hz.…”

Section: Functional Connectivity Methodsmentioning

confidence: 99%

Modulation of Sensory Perceptions and Cortical Responses Following TENS

Zarei

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Nerve Injury Decreases Hyperacute Resting-State Connectivity Between the Anterior Cingulate and Primary Somatosensory Cortex in Anesthetized Rats

Cited by 6 publications

References 39 publications

From pulse width modulated TENS to cortical modulation: based on EEG functional connectivity analysis

From pulse width modulated TENS to cortical modulation: based on EEG functional connectivity analysis

Gamma-band enhancement of functional brain connectivity following transcutaneous electrical nerve stimulation

Modulation of Sensory Perceptions and Cortical Responses Following TENS

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