Nerve-sheath myxoma (neurothekeoma) of the oral cavity: A case report and review of the literature

Katsourakis, M; Kapranos, Nikiforos; Papanicolaou, Stavros; Patrikiou, A

doi:10.1016/s0278-2391(96)90545-5

Cited by 30 publications

(30 citation statements)

References 17 publications

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“…Mincer and Spears (7) had first reported a case in the tongue as NT in the oral cavity. To date, 16 cases (17 lesions) of intraoral NTs have been reported (2,4,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The details of the clinicopathological characteristics in the previous cases and our current cases of intraoral NTs were summarized in Table 1 and 2.…”

Section: Discussionmentioning

confidence: 89%

“…Although the tumor is defined in juxtaposition as NSM and NT, NSMs may represent a variant of NT with increased mucin deposition associated with greater age and may be subdivided into cellular or myxoid variants (16). Recently, the two variants of NT have been established by an index of the histological features with immunohistochemical characteristics: the myxoid variant is strongly positive for S-100 protein, and the cellular variant fails to express it (16,22). Argenyi et al (23) have proposed a three-part histological division of cutaneous NTs into myxoid, cellular and mixed variants.…”

Section: Discussionmentioning

confidence: 99%

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Neurothekeoma of the Oral Cavity: Report of two cases of a distinctive variant and review of the literature.

et al. 2001

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Oral Med Pathol 6(2001) 95 IntroductionNeurothekeoma (NT) including nerve sheath myxoma (NSM), is a rare neoplasm arising from the endoneurium of the peripheral nerves. In 1969, Harkin and Reed (1) were the first to report on this tumor in the dermis, and they termed it "myxoma of the nerve sheath". The tumor was characterized by a lobular proliferation of myxomatous tissue separated by fibrous septa. Subsequently, Gallager and Helwig (2) reported 53 cases of a benign tumor of the dermis and subcutaneous tissue that was histologically suggestive of "Schwann cell tumor", which they called NT. Since then, the differential diagnosis between NSM and NT has been controversial. Generally, the prevailing view has been that NSM and NT are predominantly myxoid and cellular variants of the same tumor (3), and Pulitzer and Reed (4) accepted these two lesions as synonymous in a broad sense. However, Laskin et al. (5) stated that NSM is only a hypocellular variant in the myxoid type of NT. In 1996, the World Health Organization "Histological Typing of Skin Tumours" (6) stated that NSM may represent a variant of NT with increased mucin deposition associated with greater age, and NT may be subdivided into cellular and myxoid variants. Recently, immunohistochemical analysis has been performed to determine the subdivision of NT, but there is no consistency of immunoreaction in some cases. Thus, the precise relationship between NSM and NT has not yet been completely established due to disagreement among investigators. NT often develops in the dermis and subcutis of the face, extremities, trunk and the shoulders (6), and very rarely in underlying mucous membranes. Previously, only 16 cases of intraoral NT have been reported (2,4,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). We describe the clinical and pathologic features of two cases of NT as a distinctive variant: a mixed variant arising in the buccal mucosa and a myxoid variant arising in the inferior surface of the tongue. In addition, previously reported intraoral lesions of this tumor are reviewed. Case Reports Case 1A 59-year-old man visited our outpatient clinic on May 20, 1992, with a chief complaint of a gradually enlarging mass in the buccal mucosa. The patient had repeated formation of a submucosal hematoma in the left buccal mucosa during the prvious two years, due to biting. Physical examination revealed a pedunculated polypous mass measuring 10¥14¥7 mm in size on the left buccal mucosa corresponding to the bite-surface of the Neurothekeoma of the Oral Cavity: Report of two cases of a distinctive variant and review of the literature

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Neurothekeoma of the Oral Cavity: Report of two cases of a distinctive variant and review of the literature.

et al. 2001

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“…SMA positivity suggests some similarity to the epithelioid variant of leiomyoma or myofibroblastic proliferations [14]. GFAP positivity is rare in NSM; however, its positivity further supports a peripheral nerve sheath origin as occasional peripheral nerve sheath tumors may co-express GFAP and S100 [15].…”

Section: Discussionmentioning

confidence: 94%

Nerve Sheath Myxoma (Neurothekeoma) of the Gingiva, A Case Report and Review of the Literature

Safadi

Hellstein

Diab

et al. 2010

Head and Neck Pathol

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Nerve sheath myxoma (NSM) is a benign peripheral nerve sheath tumor that rarely occurs in the oral cavity. Among the 23 reported intraoral cases, no lesion has previously been reported on the gingiva. In this report, we describe the first gingival case of oral neurothekeoma with histopathologic and immunohistochemical characteristics. The patient, a 32 year old female presented with a slowly growing gingival mass diagnosed clinically as an epulis. The lesion was surgically excised. Histopathologically, the lesion presented as a submucosal multinodular mass composed of spindle and stellate-shaped cells with a myxoid background. Immunohistochemically, the tumor cells were sporadically positive for S-100 and NSE and negative for GFAP, EMA, SMA, CD68 and HMB45. The immunoprofile of this lesion confirmed a Schwann cell origin. The lesion was followed up for 10 months with no reports of recurrence.

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“…Smooth muscle actin (SMA) positivity suggests some similarity to the epithelioid variant of leiomyoma or myofibroblastic proliferations [11]. Glial fibrillary acidic protein (GFAP) positivity is rare in neurothekeoma; however, its positivity further supports a peripheral nerve sheath origin, as occasional peripheral nerve sheath tumors may coexpress GFAP and S-100 [12]. Complete excision is the mainstay of treatment for neurothekeoma.…”

Section: Discussionmentioning

confidence: 99%

Neurothekeoma Thumb

Raju¹,

Nambiar²,

Kumar³

et al. 2017

JCR

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Background: Neurothekeomas are rare benign neoplasms typically occurring in young female patients. The usual presentations are small nodules in different anatomical sites commonly involving the face and the upper limb. Case Report: Here we describe a 52 year-old male who had a swelling in the left thumb for 2 years. Histology showed lobulated mass within the dermis containing spindle cells and abundant myxoid matrix. Immunohistochemistry was positive for S100. These findings were compatible with myxoid neurothekeoma. The lesion was completely excised and at the 6-month followup the patient was asymptomatic and had no recurrences. Conclusion: This case of neurothekeoma is an exception as the presentation involves thumb involvement which opined as myxoid neurothekeoma and no recurrence of tumor was reported on follow-up.

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Nerve-sheath myxoma (neurothekeoma) of the oral cavity: A case report and review of the literature

Cited by 30 publications

References 17 publications

Neurothekeoma of the Oral Cavity: Report of two cases of a distinctive variant and review of the literature.

Neurothekeoma of the Oral Cavity: Report of two cases of a distinctive variant and review of the literature.

Nerve Sheath Myxoma (Neurothekeoma) of the Gingiva, A Case Report and Review of the Literature

Neurothekeoma Thumb

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