Nerve sheath myxoma of the tongue in a child

Utsunomiya, Tohru; Kamino, Yoshikazu; Kobayashi, Ryoki; Fukumoto, Masahiko; Yamamoto, Hirotsugu; Nagura, Hideaki

doi:10.1054/ijom.2001.0202

Cited by 24 publications

(18 citation statements)

References 13 publications

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“…Both lesions present similar clinical characteristics and biological behavior. The overall histological appearance of NSM is a well‐circumscribed, but nonencapsulated lesion, characteristically showing proliferation of spindle, stellate, and occasionally epithelioid‐shaped cells . The stroma usually presents an abundant myxoid background/matrix of mucopolysaccharide, composed by hyaluronic acid .…”

Section: Discussionmentioning

confidence: 99%

“…Nerve sheath myxoma (NSM) is an uncommon benign peripheral nerve sheath neoplasm first described in 1969 by Harkin and Reed and Scheithauer et al This neoplasm arises most commonly within the dermis and subcutaneous tissues on the face and upper extremities and is extremely rare in the intraoral region . Intraoral NSM was first reported in 1974 by Mincer and Spears and few cases in the oral mucosa were reported so far in the medical literature …”

Section: Introductionmentioning

confidence: 99%

“…In 1980, Gallager and Helwig introduced the term neurothekeoma in the literature to designate a benign cutaneous tumor, regarded as having a neural origin, which shared many clinical and histological similarities to NSM. Since then, many authors have considered NSM and neurothekeoma as variants of the same tumor, being the NSM, the myxoid, or hypocellular variant and the neurothekeoma the cellular variant . Although currently, it is known that they are distinct lesions with different origins and distinct morphological and immunohistochemical features, the terms NSM and neurothekeoma have been erroneously used interchangeably, causing great confusion.…”

Section: Introductionmentioning

confidence: 99%

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Intraoral nerve sheath myxoma: Case report and systematic review of the literature

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intraoral nerve sheath myxoma: Case report and systematic review of the literature

et al. 2013

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“…Schortinghuis [5] reported a myxoid case of nerve sheath myxoma which was negative for S100 while the myxoid NSM cases reported by Nishioka [3] and Makino [9] were S100 and NSE positive. Penarrocha [4] and Nishioka et al [3] reported two mixed-type cases, which were positive for both S100 and NSE.…”

Section: Discussionmentioning

confidence: 97%

Nerve Sheath Myxoma (Neurothekeoma) of the Gingiva, A Case Report and Review of the Literature

Safadi

Hellstein

Diab

et al. 2010

Head and Neck Pathol

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Nerve sheath myxoma (NSM) is a benign peripheral nerve sheath tumor that rarely occurs in the oral cavity. Among the 23 reported intraoral cases, no lesion has previously been reported on the gingiva. In this report, we describe the first gingival case of oral neurothekeoma with histopathologic and immunohistochemical characteristics. The patient, a 32 year old female presented with a slowly growing gingival mass diagnosed clinically as an epulis. The lesion was surgically excised. Histopathologically, the lesion presented as a submucosal multinodular mass composed of spindle and stellate-shaped cells with a myxoid background. Immunohistochemically, the tumor cells were sporadically positive for S-100 and NSE and negative for GFAP, EMA, SMA, CD68 and HMB45. The immunoprofile of this lesion confirmed a Schwann cell origin. The lesion was followed up for 10 months with no reports of recurrence.

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“…Neurothekeomas are generally slow-growing and manifest as a solitary papule or nodule, which is typically located on the head, neck or upper extremities (4)(5)(6)(7)(8)(9)(10). In a small number of cases, the solitary papule or nodule may be located in the oral cavity, breast, tongue, maxilla (11)(12)(13)(14), cranial cavity (10) or spinal intradural space (15). Though the shoulder has been described as a common site of neurothekeoma development (3)(4)(5)(6), there have been few cases of humeral neurothekeoma reported in detail in the relevant literature (6,16).…”

Section: Introductionmentioning

confidence: 99%

A giant neurothekeoma of the left shoulder blade: A case report

et al. 2015

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Abstract. Neurothekeoma is a rare myxoma of the peripheral nerve sheath. The current report presents a case of a giant neurothekeoma with a partially-formed capsule, scapula erosion and unclear biological behavior, which originated in the intermuscular space between the left trapezius muscle and scapula. The patient was initially misdiagnosed with a fibromatosis using computed tomography and magnetic resonance image scanning. Diagnosis of the neoplasm was confirmed by pathological and immunohistochemical examination, revealing a neurothekeoma with unclear biological behavior. The patient underwent a wide and complete local resection. Using a comprehensive postoperative follow-up strategy, it was determined that the patient recovered well. The tumor was ~17x16x10 cm in size and was in contact with the scapula. The purpose of the present study was to describe a rare giant neurothekeoma and review the diagnostic techniques utilized to reach a definitive diagnosis. Histopathological and immunohistochemical analyses were recommended for the diagnosis of neurothekeoma. There have been no previous reports regarding neurothekeomas exhibiting malignant transformation. Early and complete surgical resection is considered to be an effective method of treating this type of neurothekeoma.

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Nerve sheath myxoma of the tongue in a child

Cited by 24 publications

References 13 publications

Intraoral nerve sheath myxoma: Case report and systematic review of the literature

Intraoral nerve sheath myxoma: Case report and systematic review of the literature

Nerve Sheath Myxoma (Neurothekeoma) of the Gingiva, A Case Report and Review of the Literature

A giant neurothekeoma of the left shoulder blade: A case report

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