Abstract:The beneficial effects (in terms of operative time and number of nodes harvested) of NS-LRH are likely determined by the expertise of the surgeon because NS approach was introduced after having acquired adequate background in conventional LRH. Our data show that in experienced hands NS-LRH is safe and feasible. Moreover, NS technique reduces catheterization time and the rate of postoperative urinary dysfunction.
“…Eight studies reported data on urinary incontinence after NSRH and RH [14,18,19,25,26,28,30,31]. Data extracted from the eight studies were meta-analyzed using a fixed effect model because of low heterogeneity among the trials (P ≥ 0.05, I…”
Section: Resultsmentioning
confidence: 99%
“…Six studies met our inclusion criteria reported overall recurrence rate [14,16,17,[23][24][25]. We extracted the overall recurrence data and used random effects model in this meta-analysis due to high heterogeneity among studies (P < 0.05, I…”
Section: Resultsmentioning
confidence: 99%
“…In order to make the data comparable, we calculated the mean time and standard deviation of data in 3 studies [13,25,27], which only reported the median time and range of catheterization by using the Hozo and colleagues' methods [10]. Meta-analysis of the 11 studies' data on mean time of catheterization indicated that NSRH had a significantly shorter mean time of catheterization than RH (n = 686, MD = -8.01, 95% CI -10.64 to -5.38, P < 0.00001; Fig.…”
Section: Resultsmentioning
confidence: 99%
“…33 Although anorectal function outcomes were reported by several studies, we only found 2 relevant studies with comparable data on anorectal dysfunction [18,25]. Due to various parameters indicating anorectal dysfunction such as constipation, defecation straining, stool incontinence and flatulence incontinence, we chose constipation as the comparable parameter of anorectal dysfunction in this review [32].…”
Section: Main Findingsmentioning
confidence: 99%
“…Seven studies were included in this review for a meta-analysis with local recurrence rate data [14,16,17,[23][24][25]31], of which six studies reported overall recurrence rate data as well [14,16,17,[23][24][25]. Meta-analysis of these local and overall recurrence rate data didn't show significant differences after NSRH and RH procedures.…”
Background/Aims: Radical hysterectomy (RH) for the treatment of cervical cancer frequently caused pelvic organ dysfunctions. This study aimed to compare the results of pelvic organ function and recurrence rate after Nerve sparing radical hysterectomy (NSRH) and RH treatment through systematic review and meta-analysis. Methods: PubMed, Web of Science and China Knowledge Resource Integrated Database were searched from inception to 25 February 2015. Studies of cervical cancer which reported radical hysterectomy or nerve sparing radical hysterectomy were included. The quality of included studies was evaluated using the guidelines of Cochrane Handbook for Systematic Reviews of Interventions. Statistical analysis was performed using Review Manager 5.3 software (Cochrane Collaboration). Results: A total of 20 studies were finally included. Meta-analysis demonstrated that NSRH was associated with less bladder and anorectal dysfunction than RH. The time to bladder and anorectal function recovery after NSRH was shorter than RH. Patients undergoing NSRH also scored higher than patients undergoing RH at Female Sexual Function Index (FSFI). On the other hand, the local recurrence and overall recurrence rate were similar between NSRH and RH. Conclusion: NSRH may be an effective technique for lowering pelvic organ dysfunction and improving the function recovery without increasing the recurrence rate of cervical cancer.
“…Eight studies reported data on urinary incontinence after NSRH and RH [14,18,19,25,26,28,30,31]. Data extracted from the eight studies were meta-analyzed using a fixed effect model because of low heterogeneity among the trials (P ≥ 0.05, I…”
Section: Resultsmentioning
confidence: 99%
“…Six studies met our inclusion criteria reported overall recurrence rate [14,16,17,[23][24][25]. We extracted the overall recurrence data and used random effects model in this meta-analysis due to high heterogeneity among studies (P < 0.05, I…”
Section: Resultsmentioning
confidence: 99%
“…In order to make the data comparable, we calculated the mean time and standard deviation of data in 3 studies [13,25,27], which only reported the median time and range of catheterization by using the Hozo and colleagues' methods [10]. Meta-analysis of the 11 studies' data on mean time of catheterization indicated that NSRH had a significantly shorter mean time of catheterization than RH (n = 686, MD = -8.01, 95% CI -10.64 to -5.38, P < 0.00001; Fig.…”
Section: Resultsmentioning
confidence: 99%
“…33 Although anorectal function outcomes were reported by several studies, we only found 2 relevant studies with comparable data on anorectal dysfunction [18,25]. Due to various parameters indicating anorectal dysfunction such as constipation, defecation straining, stool incontinence and flatulence incontinence, we chose constipation as the comparable parameter of anorectal dysfunction in this review [32].…”
Section: Main Findingsmentioning
confidence: 99%
“…Seven studies were included in this review for a meta-analysis with local recurrence rate data [14,16,17,[23][24][25]31], of which six studies reported overall recurrence rate data as well [14,16,17,[23][24][25]. Meta-analysis of these local and overall recurrence rate data didn't show significant differences after NSRH and RH procedures.…”
Background/Aims: Radical hysterectomy (RH) for the treatment of cervical cancer frequently caused pelvic organ dysfunctions. This study aimed to compare the results of pelvic organ function and recurrence rate after Nerve sparing radical hysterectomy (NSRH) and RH treatment through systematic review and meta-analysis. Methods: PubMed, Web of Science and China Knowledge Resource Integrated Database were searched from inception to 25 February 2015. Studies of cervical cancer which reported radical hysterectomy or nerve sparing radical hysterectomy were included. The quality of included studies was evaluated using the guidelines of Cochrane Handbook for Systematic Reviews of Interventions. Statistical analysis was performed using Review Manager 5.3 software (Cochrane Collaboration). Results: A total of 20 studies were finally included. Meta-analysis demonstrated that NSRH was associated with less bladder and anorectal dysfunction than RH. The time to bladder and anorectal function recovery after NSRH was shorter than RH. Patients undergoing NSRH also scored higher than patients undergoing RH at Female Sexual Function Index (FSFI). On the other hand, the local recurrence and overall recurrence rate were similar between NSRH and RH. Conclusion: NSRH may be an effective technique for lowering pelvic organ dysfunction and improving the function recovery without increasing the recurrence rate of cervical cancer.
Open approach is the main predictor for developing morbidity among cervical cancer patients undergoing radical hysterectomy followed by adjuvant radiotherapy. Laparoscopic surgery enhances peri-operative surgical results and minimizes the occurrence of late complications.
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