Nerve terminal sprouting in botulinum type-A treated mouse levator auris longus muscle

Juzans, Pascal; Comella, Joan X.; Molgó, Jordi; Faille, Lucette; Angaut-Petit, D.

doi:10.1016/0960-8966(96)00041-7

Cited by 81 publications

(51 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…54 There is also evidence forncpuro_2007_279f3.eps subsequent compensatory nerve sprouting and the creation of extrajunctional synapses. [55][56][57][58] When exocytosis at the parent terminal eventually recovers, the nerves retract and endplate functioning returns to normal. 55,59 BTX-A administration has a similar effect on neuroeffector transmission in both smooth and striated muscle.…”

Section: Action On Striated Versus Smooth Musclementioning

confidence: 99%

Drug Insight: biological effects of botulinum toxin A in the lower urinary tract

et al. 2008

View full text Add to dashboard Cite

SUMMARYBotulinum toxins can effectively and selectively disrupt and modulate neurotransmission in striated muscle. Recently, urologists have become interested in the use of these toxins in patients with detrusor overactivity and other urological disorders. In both striated and smooth muscle, botulinum toxin A (BTX-A) is internalized by presynaptic neurons after binding to an extracellular receptor (ganglioside and presumably synaptic vesicle protein 2C). In the neuronal cytosol, BTX-A disrupts fusion of the acetylcholine-containing vesicle with the neuronal wall by cleaving the SNAP-25 protein in the synaptic fusion complex. The net effect is selective paralysis of the low-grade contractions of the unstable detrusor, while still allowing high-grade contraction that initiates micturition. Additionally, BTX-A seems to have effects on afferent nerve activity by modulating the release of ATP in the urothelium, blocking the release of substance P, calcitonin gene-related peptide and glutamate from afferent nerves, and reducing levels of nerve growth factor. These effects on sensory feedback loops might not only help to explain the mechanism of BTX-A in relieving symptoms of overactive bladder, but also suggest a potential role for BTX-A in the relief of hyperalgesia associated with lower urinary tract disorders.

show abstract

Section: Action On Striated Versus Smooth Musclementioning

confidence: 99%

Drug Insight: biological effects of botulinum toxin A in the lower urinary tract

et al. 2008

View full text Add to dashboard Cite

show abstract

“…As the fusion of the vesicle membranes becomes inhibited, there is a temporary blockade of acetylcholine release at cholinergic synapses, causing a local chemodenervation. Temporary synapses are consequently formed via the process of axonal sprouting (Duchen 1971;Holland 1981;Juzans 1996).…”

Section: Description Of the Interventionmentioning

confidence: 99%

Botulinum toxin type A versus botulinum toxin type B for cervical dystonia

Duarte

Castelão

Rodrigues

et al. 2016

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

“…Nerve terminal sprouts increases in number, length and complexity even after the functional recovery of neuromuscular transmission. 4,5 Epidemiology IB is a restricted age-range disease. Ninety-five percent of all recognized cases have occurred in patients between 6 weeks and 6 months of age.…”

mentioning

confidence: 99%

Infant botulism

Brook

2007

J Perinatol

View full text Add to dashboard Cite

Infant botulism results from the absorption of heat-labile neurotoxin produced in situ by ingested Clostridium botulinum. Honey and environmental exposure are the main sources of acquisition of the organism. Clinical manifestations are owing to progressive neuromuscular blockade, initially of muscles innervated by cranial nerves and later of the trunk, extremities and diaphragm. Presynaptic autonomic nerves are also affected. The diagnosis is made on clinical grounds and is confirmed by recovery of the organism or by detection of toxin in the stool. Management includes meticulous supportive intensive care that may include mechanical ventilation and administration of human botulinum immunoglobulin in severe cases.

show abstract

Nerve terminal sprouting in botulinum type-A treated mouse levator auris longus muscle

Cited by 81 publications

References 29 publications

Drug Insight: biological effects of botulinum toxin A in the lower urinary tract

Drug Insight: biological effects of botulinum toxin A in the lower urinary tract

Botulinum toxin type A versus botulinum toxin type B for cervical dystonia

Infant botulism

Contact Info

Product

Resources

About