Nerve-tumor crosstalk in tumor microenvironment: From tumor initiation and progression to clinical implications

Zhang, Zheng; Lv, Zhen Gang; Lu, Miao; Li, Haifeng; Zhou, Jiahua

doi:10.1016/j.bbcan.2024.189121

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

2024

DOI: 10.1016/j.bbcan.2024.189121

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Nerve-tumor crosstalk in tumor microenvironment: From tumor initiation and progression to clinical implications

Zheng Zhang,

Zhen Gang Lv,

Miao Lu

et al.

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Layered Double Hydroxides for Radium‐223 Targeted Alpha Therapy with Elicitation of the Immune Response

Yang,

Li,

Han

et al. 2024

Adv Healthcare Materials

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Targeted Alpha therapy (TAT) has promising application prospects in tumor therapy. It is very appealing to design alpha‐emitting radiopharmaceuticals that can modulate the immune microenvironment to overcome the limitations of immunotherapy. Herein, Mg/Al layered double hydroxide nanomaterials (LDH) are utilized to load the alpha‐emitting nuclide Radium‐223 (223Ra), achieving precise delivery of 223Ra to the tumor microenvironment. Dual‐modal imaging is employed to dynamically monitor the in vivo distribution of 223Ra‐LDH, ensuring its prolonged retention at the tumor site. In vitro experimentsshowed that ionizing radiation from alpha‐emitting nuclides effectively reduced glutathione (GSH) and produced large amounts of reactive oxygen species (ROS), which damaged mitochondria and released free calcium (Ca2+), thereby aggravating tumor cell death. Additionally, DNA double‐strand breaks induced by alpha‐emitting radiation triggered the STING signaling pathway, which in turn effectively induced immunogenic cell death (ICD) and promoted immune cell maturation and activation. The synergistic effect with immunotherapy triggered a powerful systemic antitumor immune response. Overall, this study develops a novel TAT therapeutic strategy with sufficient antitumor immunity.

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Layered Double Hydroxides for Radium‐223 Targeted Alpha Therapy with Elicitation of the Immune Response

Yang,

Li,

Han

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

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Nerve-tumor crosstalk in tumor microenvironment: From tumor initiation and progression to clinical implications

Cited by 1 publication

References 228 publications

Layered Double Hydroxides for Radium‐223 Targeted Alpha Therapy with Elicitation of the Immune Response

Layered Double Hydroxides for Radium‐223 Targeted Alpha Therapy with Elicitation of the Immune Response

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