Nervogenic Acid Derivatives and Phenanthrenes from Liparis nervosa and Their Antimicrobial and Immunosuppressive Activities

Abstract

Two new nervogenic acid derivatives liparisnervosides Q (1) and R (5), as well as five known nervogenic acid derivatives (2−4, 6, 7) and four phenanthrenes (8−11) were isolated from the whole plant of Liparis nervosa (Thunb. ex A. Murray) Lindl.. Their structures were detremined using extensive spectroscopic techniques, including 1D, 2D NMR, and HR‐ESI‐MS, and acid hydrolysis. Furthermore, their antimicrobial and immunosuppressive activities were evaluated. Nervosine Ⅶ (3) exhibited antimicrobial activity against Staphylococcus aureus with an MIC of 62.5 μg/mL and inhibited the proliferation of human T cells with an IC50 value of 9.67 ± 0.96 μM. These findings contribute to our understanding of the potential pharmacological properties of these compounds.