Nervous Symptoms as Earliest Manifestations of Carcinoma of the Pancreas

Abstract

of toxemia, twice during difficult versions in primiparous patients, and three times of unknown causes. Diagnosis of cerebral hemorrhage was made eight times : four times clinically and four times by autopsy observations. Of these eight cases, five occurred among patients in whom the second stage was prolonged over

Mood and Anxiety Disorders as Early Manifestations of Medical Illness: A Systematic Review

“…In 1931, depression, anxiety, insomnia, and weight loss were described for the first time as earliest manifestations of pancreatic cancer [22]. Later, several studies confirmed depression as a prodrome of this disease [23,24,25,26].…”

Depression in Pancreatic Cancer: Sense of Impending Doom

“…In contrast, reporting high incidence rates for Pancreatic cancer is still one of the malignancies with the worst prognosis and associated with a high prevalence of depression. This relationship was already described about 70 years ago, but is still poorly understood [1,2] . Dealing with this subject, one pivotal question remains: is this depression a feature of pancreatic cancer per se or is it rather a response to the experience of gradual loss of strength and body weight in patients with a life-threatening diagnosis?…”

“…After the initial description in 1931, several studies have reported on the association between pancreatic cancer and the triad of anxiety, depression and 'sense of impending doom' [1,2,4,5] . Remarkably high incidence rates were affirmed by a study in 1993 which showed depressive symptoms in 71% of the explored pancreatic cancer patients and 'anxiety-related symptoms' in 48% of the patients [6] .…”

Gastrointestinal Disorders and “Medical Depression”

“…Long before the advent of psychotropic medications, Yaskin 4 in 1931 reported that clinical depression may be the earliest manifestation of a pancreatic carcinoma. Later work demonstrated that pancreatic cancer is the entity with the highest incidence of depression among all tumors of the digestive system.…”