Nervous System Disorders of Nonhuman Primates and Research Models

Fahey, MicheleA.; Westmoreland, SusanV.

doi:10.1016/b978-0-12-381366-4.00015-8

Cited by 8 publications

(4 citation statements)

References 438 publications

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“…Prevention of disease may be accomplished through screening of personnel to ensure adequate vaccination or measles infection history and/or vaccination of susceptible primate populations (Willy et al, 1999). Vaccination is most important in New World species, especially marmosets, as measles can cause a high mortality rate of 25-100% (Albrecht et al, 1980;Levy and Mirkovic, 1971;Fahey and Westmoreland, 2012). Vaccination is most important in New World species, especially marmosets, as measles can cause a high mortality rate of 25-100% (Albrecht et al, 1980;Levy and Mirkovic, 1971;Fahey and Westmoreland, 2012).…”

Section: B Paramyxovirusesmentioning

confidence: 99%

Nonhuman Primates

Magden

Mansfield²,

Simmons

et al. 2015

Laboratory Animal Medicine

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Section: B Paramyxovirusesmentioning

confidence: 99%

Nonhuman Primates

Magden

Mansfield²,

Simmons

et al. 2015

Laboratory Animal Medicine

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“…CMV-infected fibroblasts, macrophages and endoneurial cells are commonly noted [84]. A similar phenomenon has also been observed in SIV-infected rhesus macaques with recrudescent rhesus CMV infection causing lesions in peripheral nerves and nerve roots along the spinal cord [85]. Some lesions can affect the DRG; however, functional tests to determine if clinical features of sensory neuropathy develop have not been explored [Miller AD, Unpublished Data].…”

Section: Siv Infection Of Nonhuman Primates As Models Of Hiv Sensory mentioning

confidence: 83%

Animal Models of HIV Peripheral Neuropathy

Burdo

Miller

2014

Future Virol.

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The use of animal models in the study of HIV and AIDS has advanced our understanding of the underlying pathophysiologic mechanisms of infection. Of the multitude of HIV disease manifestations, peripheral neuropathy remains one of the most common long-term side effects. Several of the most important causes of peripheral neuropathy in AIDS patients include direct association with HIV infection with or without antiretroviral medication and infection with opportunistic agents. Because the pathogeneses of these diseases are difficult to study in human patients, animal models have allowed for significant advancement in the understanding of the role of viral infection and the immune system in disease genesis. This review focuses on rodent, rabbit, feline and rhesus models used to study HIV-associated peripheral neuropathies, focusing specifically on sensory neuropathy and antiretroviral-associated neuropathies.

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“…1 In addition, rhesus macaque models of human neurologic conditions such as Parkinson's disease, multiple sclerosis, and stroke have been developed. 1 Ataxia, paresis or paralysis, and seizure are the common neurologic signs associated with non-specific nervous system disorder in NHPs. Investigating the cause of neurologic disease often requires antemortem testing, including neurologic examination, cerebrospinal fluid (CSF) analysis, and magnetic resonance imaging, as well as postmortem examination.…”

Section: Introductionmentioning

confidence: 99%

“…Nervous system disorders in rhesus macaques ( Macaca mulatta ), as in other veterinary species, range from naturally occurring infections to congenital and developmental diseases to metabolic derangements to primary and metastatic neoplasms, although the latter are relatively rare in non‐human primates (NHPs) . In addition, rhesus macaque models of human neurologic conditions such as Parkinson's disease, multiple sclerosis, and stroke have been developed . Ataxia, paresis or paralysis, and seizure are the common neurologic signs associated with non‐specific nervous system disorder in NHPs.…”

Section: Introductionmentioning

confidence: 99%

Cerebral cysts of ependymal or ventricular origin in a juvenile rhesus macaque (Macaca mulatta) with neurologic signs

Pecoraro

Haertel

Cullin

et al. 2019

J of Medical Primatology

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Naturally occurring neurologic disease in non-human primates may be attributable to a wide-range of causes, including infectious agents, congenital or acquired malformations, degenerative diseases, and, rarely, neoplasia. We report a case of ataxia and paresis in a juvenile rhesus macaque with ependymal-lined cerebral cysts. K E Y W O R D S ataxia, brain cyst, non-human primate, paresis | 379 PECORARO Et Al. How to cite this article: Pecoraro HL, Haertel AJ, Cullin C, Prongay K, Lewis AD, Ducore R. Cerebral cysts of ependymal or ventricular origin in a juvenile rhesus macaque (Macaca mulatta) with neurologic signs. J Med Primatol. 2019;48:378-380. https ://doi.

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Nervous System Disorders of Nonhuman Primates and Research Models

Cited by 8 publications

References 438 publications

Nonhuman Primates

Nonhuman Primates

Animal Models of HIV Peripheral Neuropathy

Cerebral cysts of ependymal or ventricular origin in a juvenile rhesus macaque (Macaca mulatta) with neurologic signs

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