Nesfatin-1 in childhood and adolescent obesity and its association with food intake, body composition and insulin resistance

Background/Aims: The alterations of eating behavior are insufficiently recognized in the clinical attention of adults with obesity. The objective of this study was to examine the characteristics of overeating behavior and its association with depression, perceived stress, acylated ghrelin, nestafin-1, and cortisol. Methods: This cross-sectional comparative study included 80 participants with obesity and 50 with normal weight. The volunteers completed questionnaires to evaluate symptoms of food addiction (FA), obsessive compulsive, binge eating (BE), depression, and perceived stress. We measured glucose, lipids, acylated ghrelin, nesfatin-1, and insulin in a fasting blood sample as well as urine cortisol. We compared groups with students t test, and analysis of variance, and tested associations by logistic and multiple regression. Results: By multiple regression, the BE total score was positively associated with the FA (p < 0.0001) and depression total score (p < 0.0001). By logistic regression, the positive score of FA was associated with ghrelin (p < 0.02). The perceived stress total score was associated negatively with cortisol (p < 0.0006). Conclusion: The BE and FA are strongly associated in agreement with the concept that both conditions have overlapping features. Depressive symptoms are associated with symptoms of disordered eating behavior. FA positive score was associated with ghrelin. BE total score was associated with nesfatin-1.

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“…Nesfatin-1 favors insulin secretion and sensitivity; hence, its suppression in obesity may have adverse metabolic consequences [54].…”

Section: Discussionmentioning

confidence: 99%

Association of Nesfatin-1, Acylated Ghrelin and Cortisol with Scores of Compulsion, Food Addiction, and Binge Eating in Adults with Normal Weight and with Obesity

López-Aguilar¹,

Ibarra-Reynoso²,

Malacara³

2018

Ann Nutr Metab

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“…This is consistent with the study of Zhao et al (23) who investigated Nesfatin-1 in 40 hypertensive adults and 40 healthy controls, and reported significantly higher levels of Nesfatin-1 in the hypertensive group, especially in obese individuals. In the study of Anwar et al (27) the Nesfatin-1 levels were higher in obese adolescents than their healthy peers and correlated with BMI values. Their results were similar to those reported by Tan et al (28) who compared the levels of Nesfatin-1 in 38 adult subjects.…”

Section: Discussionmentioning

confidence: 89%

“…This may be due to the gradual increase in serum Nesfatin-1 level with age. In the study of Anwar et al (27) they demonstrated that as the pubertal stage progresses, serum Nesfatin-1 levels increase. In our study the study population is younger.…”

Section: Discussionmentioning

confidence: 97%

Can Nesfatin-1 Predict Hypertension in Obese Children?

Güneş¹,

Baylan²,

Güneş³

et al. 2020

Jcrpe

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Objective: The prevalence of childhood obesity is increasing and leads to co-morbidities such as hypertension. However, it is still not clear why some obese individuals are hypertensive and others not. Nesfatin-1 is a recently discovered anorexigenic peptide which also has effects on blood pressure (BP). Our aim was to evaluate the relationship between obesity-related hypertension and Nesfatin-1. Methods: This cross-sectional study comprised 87 obese children. The patients were divided into two groups; hypertensive (n=30) and normotensive (n=57) obese. The American Academy of Pediatrics guidelines were used to diagnose hypertension. Blood samples were collected after 12 hours of fasting to investigate Nesfatin-1 concentrations. We also evaluated serum trace elements in addition to the routine blood tests. Results: Body mass index (BMI), weight and serum Nesfatin-1 concentrations were higher in the hypertensive group (p=0.002, p=0.001, and p=0.007, respectively). There was no difference between serum zinc levels, but Copper (Cu) levels were significantly lower in the hypertensive group (p=0.248, p=0.007, respectively). There were positive correlations between BP and BMI and weight Z-scores and a negative correlation with Cu. The optimal cut-off value of Nesfatin-1 to predict hypertension was found to be >1.8 ng/mL, with a specificity of 71.9% and a sensitivity of 96.7% [area under the curve=0.703, 95% confidence interval (CI): 0.577-0.809; p=0.002]. In multiple logistic regression analysis Nesfatin-1 [Odds ratio (OR)=1.103, 95% CI: 1.039-1.171; p=0.001], Cu (OR=0.947, 95% CI: 0.915-0.979; p=0.001) and BMI for age Z-score (OR=56.277, 95% CI: 5.791-546.907; p=0.001) still remained significant predictors of hypertension. Conclusion: Nesfatin-1 levels are higher and are an independent predictor of hypertension in obese subjects.(2), and is over 10% in some studies (3). This increased prevalence also poses a more serious problem by increasing the incidence of obesity-related co-morbid conditions. In addition to metabolic diseases such as diabetes and insulin resistance, obese patients are prone to various cardiovascular diseases such as hypertension and dyslipidemia. This increased disease burden, starting from childhood, deserves Abstract 29 What is already known on this topic? What this study adds?Childhood obesity is increasing over the years and leads to morbidities such as hypertension.Obesity causes hypertension but the reason/s why all obese individuals are not hypertensive is controversial. This study aimed to clarify part of this issue by comparing obese peers stratified by blood pressure and found that Nesfatin-1 independently predicts hypertension in obese children.

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“…Kaba et al (12) found no significant association between BMI SDS and nesfatin-1 (neither in underweight children nor in control groups), while Kahraman et al (13) demonstrated a positive correlation between BMI SDS and nesfatin-1. Similarly, conflicting results regarding the nesfatin-1 level were observed in studies performed in obese children (32)(33)(34). Abaci et al (32) previously reported lower serum nesfatin-1 levels in obese subjects compared to those of healthy controls and a negative correlation between nesfatin-1 and BMI in nonobese males.…”

Section: Discussionmentioning

confidence: 99%

Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition

Acar¹,

Çatlı²,

Küme³

et al. 2018

Turk J Med Sci

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Background/aim: Nesfatin-1, an anorexigenic molecule, seems to play a role in appetite regulation and energy homeostasis. The goal of this study was to evaluate the relation of nesfatin-1 with anthropometric and metabolic (ghrelin, leptin) parameters in children with idiopathic chronic malnutrition. Materials and methods:The study included 37 underweight and 38 healthy children who were similar regarding age, sex, and pubertal status. Anthropometric and biochemical (nesfatin-1, ghrelin, and leptin levels) variables were assessed.Results: A total of 37 underweight subjects (mean age 10.5 ± 2.6 years) and 38 heathy subjects (mean age 10.3 ± 2.3 years) were recruited. Underweight children had significantly higher nesfatin-1 (2.76 ± 0.4 vs. 1.56 ± 0.7, P < 0.001) and lower leptin levels (2.21 ± 2.0 vs. 5.21 ± 2.4, P < 0.001) than those of the control subjects. Nesfatin-1 levels were significantly associated with only leptin levels, after adjusting for age and BMI (r = -0.371, P = 0.001). Conclusion:The present study is the first to evaluate nesfatin-1 levels in relation with anthropometric and metabolic parameters in children with chronic malnutrition, who were subsequently found to have significantly higher nesfatin-1 levels. Our study underlines that nesfatin-1 may play a role in the development of malnutrition by inhibiting food intake in children.

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Nesfatin-1 in childhood and adolescent obesity and its association with food intake, body composition and insulin resistance

Cited by 55 publications

References 20 publications

Association of Nesfatin-1, Acylated Ghrelin and Cortisol with Scores of Compulsion, Food Addiction, and Binge Eating in Adults with Normal Weight and with Obesity

Association of Nesfatin-1, Acylated Ghrelin and Cortisol with Scores of Compulsion, Food Addiction, and Binge Eating in Adults with Normal Weight and with Obesity

Can Nesfatin-1 Predict Hypertension in Obese Children?

Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition

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