Nesfatin‑1 is a potential diagnostic biomarker for gastric cancer

Wang, Xiaoqing; Zheng, Yan; Fang, Peifei; Song, Xianbing

doi:10.3892/ol.2019.11200

Cited by 9 publications

(13 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An in vivo study demonstrated that injecting nesfatin-1 into the third cerebral ventricle of high-fat diet-fed rats contributed to promoting insulin-induced glucose uptake and insulin signaling through upregulating the phosphorylation levels of insulin receptors ( 20 ). Additionally, nesfatin-1 was observed to be augmented in gastric cancer and exerts a decent role in diagnosing gastric cancer (Area Under the Curve (AUC) = 0.857, 95% CI 0.769–0.946) with a threshold of 1.075 ng/ml ( 61 ). Although there is a growing body of evidence on nesfatin-1’s versatility, its receptor remains unknown.…”

Section: Discussionmentioning

confidence: 99%

The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6, and TNF-α Levels in Prediabetes

Huang

Liang

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundThe variation and correlation among adiponectin, nesfatin-1, tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6), which may be involved in the development of the decline of health into prediabetes and diabetes, have not been elucidated. This study aims to investigate the roles of these cytokines in this process.MethodsSeventy-two type 2 diabetes mellitus (T2DM) patients, 75 prediabetics, and 72 healthy individuals were enrolled in our case control study. Serum adiponectin, nesfatin-1, TNF-α, and IL-6 were tested with appropriate kits, and primary data were analyzed with correct methods.ResultsSerum levels of each cytokine in patients with prediabetes were between T2DM and the healthy, and significant differences were found among them. TNF-α and nesfatin-1 levels in T2DM were obviously different compared to prediabetes or the healthy; IL-6 and adiponectin levels in the healthy group were significantly changed in contrast to prediabetes or T2DM. Correlation analysis found that in prediabetics, adiponectin was positively correlated with TNF-α (R = 0.2939, P = 0.0105) and IL-6 (R = 0.3918, P = 0.0005), and their relationship was greatly strengthened in prediabetes accompanied by insulin resistance (TNF-α: R = 0.7732, P < 0.0001, IL-6: R = 0.6663, P = 0.0005). We also demonstrated that declined adiponectin (OR = 6.238, P = 0.019) and nesfatin-1 (OR = 2.812, P = 0.01) and elevated TNF-α (OR = 5.541, P = 0.001) were risk factors for prediabetes toward diabetes.ConclusionsThis research proved significant variations of adiponectin, nesfatin-1, IL-6, and TNF-α levels in the healthy, prediabetics, and T2DM, suggesting a slow and gradual change during the progression from a healthy condition toward diabetes via prediabetes.

show abstract

Section: Discussionmentioning

confidence: 99%

The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6, and TNF-α Levels in Prediabetes

Huang

Liang

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…It has been suggested that adipocytokines may be new biological markers that can be used in the diagnosis of a number of diseases. 41 , 42 In terms of nesfatin-1, nesfatin-1 has been reported to be capable of distinguishing patients from the healthy population in gastric cancer, 43 major depression 44 and epilepsy. 45 Therefore, in the present study, the potential of nesfatin-1 as a biomarker for RA diagnosis was investigated.…”

Section: Discussionmentioning

confidence: 99%

Elevated Nesfatin-1 Level in Synovium and Synovial Fluid is Associated with Pro-Inflammatory Cytokines in Patients with Rheumatoid Arthritis

Zhang

Rong²,

Xu³

et al. 2021

IJGM

View full text Add to dashboard Cite

Background: Adipocytokines have been proven to be involved in the progression of autoimmune diseases, including rheumatoid arthritis (RA). Nesfatin-1, a newly discovered adipokine, has recently been reported to possess potent anti-inflammatory, antiapoptotic, and antioxidative properties. However, its role in RA has not yet been reported. Therefore, this study aimed to determine nesfatin-1 levels in the synovium and synovial fluid (SF) of patients with RA and examine their correlation with clinical manifestations and proinflammatory cytokine levels. Methods: Synovium and SF samples were collected from patients with RA and non-RA patients during joint surgery. Immunohistochemistry was used to measure nesfatin-1 protein expression in the synovium. Enzyme-linked immunosorbent assay was used to measure nesfatin-1, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) levels in the synovium and SF. Pearson correlation analysis was used to evaluate the correlations between nesfatin-1 levels, RA clinical features, and proinflammatory cytokines. The diagnostic value of synovium nesfatin-1 for RA was assessed using receiver operating characteristic (ROC) curve analysis. Results: The results showed that nesfatin-1, IL-1β, and TNF-α levels in the synovium were significantly higher in patients with RA than in controls, with age and body mass index as covariates. Moreover, the results of Pearson correlation analysis showed that nesfatin-1 levels were positively correlated with IL-1β and TNF-α levels in the synovium of patients with RA. Furthermore, there was a positive relationship between synovium nesfatin-1 levels and rheumatoid factor in patients with RA. Additionally, the results of the ROC curve analysis revealed an area under the curve of 0.733 with 77.5% sensitivity and 60.0% specificity for synovium nesfatin-1 in discriminating patients with RA from controls. Conclusion: These findings suggest that increased nesfatin-1 levels in the synovium may be associated with proinflammatory cytokines and RA severity.

show abstract

“…In that experiment, the overriding control of the gut by the central nervous system was virtually eliminated, which may further suggest that regulation of peripheral nesfatin-1 secretion is mediated by an intrinsic (likely enteric) nervous mechanism. A more recent study found increased plasma levels of nesfatin-1 in cancer patients, but it is not clear whether it was of central of peripheral origin [ 29 ].…”

Section: Role Of Nesaftin-1 In Gastrointestinal Tract Disordersmentioning

confidence: 99%

Minireview: Peripheral Nesfatin-1 in Regulation of the Gut Activity—15 Years since the Discovery

Kras

Muszyński

Tomaszewska

et al. 2022

Animals

View full text Add to dashboard Cite

Nesfatin-1, discovered in 2006, is an anorexigenic molecule derived from the precursor protein NEFA/nucleobindin2. It is generally postulated that this molecule acts through a specific G protein-coupled receptor, as yet unidentified. Research conducted over the last 15 years has revealed both central and peripheral actions of nesfatin-1. Given its major central role, studies determining its inhibitory effect on food intake seem to be of major scientific interest. However, in recent years a number of experiments have found that peripheral organs, including those of the gastrointestinal tract (GIT), may also be a source (possibly even the predominant source) of nesfatin-1. This mini-review aimed to summarize the current state of knowledge regarding the expression and immunoreactivity of nesfatin-1 and its possible involvement (both physiological and pathological) in the mammalian GIT. Research thus far has shown very promising abilities of nesfatin-1 to restore the balance between pro-oxidants and antioxidants, to interplay with the gut microbiota, and to alter the structure of the intestinal barrier. This necessitates more extensive research on the peripheral actions of this molecule. More in-depth knowledge of such mechanisms (especially those leading to anti-inflammatory and anti-apoptotic effects) is important for a better understanding of the involvement of nefatin-1 in GIT pathophysiological conditions and/or for future therapeutic approaches.

show abstract

Nesfatin‑1 is a potential diagnostic biomarker for gastric cancer

Cited by 9 publications

References 43 publications

The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6, and TNF-α Levels in Prediabetes

The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6, and TNF-α Levels in Prediabetes

Elevated Nesfatin-1 Level in Synovium and Synovial Fluid is Associated with Pro-Inflammatory Cytokines in Patients with Rheumatoid Arthritis

Minireview: Peripheral Nesfatin-1 in Regulation of the Gut Activity—15 Years since the Discovery

Contact Info

Product

Resources

About