Nesidioblastosis. A case of hyperplasia of the islets of Langerhans in the adult

Nesidioblastosis Associated with Pancreatic Heterotopia as a Differential Diagnosis of Hypoglycemia: A Literature Review and Case Report

“…According to the literature, the main treatment consists of surgery, usually distal pancreatectomy [ 22 ]. As a complementary clinical treatment, there are descriptions of the use of glucocorticoids, calcium channel blockers, diazoxide [ 23 ], octreo-tide, pasireotide [ 24 ], and acarbose [ 2 ].…”

The diagnosis and management of congenital and adult-onset hyperinsulinism (nesidioblastosis) – literature review

“…Accordingtopublishedstatistics,0.5to5.0%of nesidioblastosiscasesoccurinadults [17].Thesecasesarerarebutwelldocumented [18,19,20].…”

Anesthetic management of a case of nesidioblastosis

“…[ 3 ] Usually, it presents with convulsion just after birth secondary to severe hypoglycemia. [ 4 ] Subtotal to near total pancreatectomy is indicated as a matter of urgency to decrease the amount of circulating insulin. [ 4 ] Various measures to tackle hypoglycemia have been advocated which include concentrated glucose hydrocortisone 5 mg/kg 12 hourly IV, glucagon 0.1 mg/kg, and diazoxide 10–25 mg/kg/day.…”

“…[ 4 ] Subtotal to near total pancreatectomy is indicated as a matter of urgency to decrease the amount of circulating insulin. [ 4 ] Various measures to tackle hypoglycemia have been advocated which include concentrated glucose hydrocortisone 5 mg/kg 12 hourly IV, glucagon 0.1 mg/kg, and diazoxide 10–25 mg/kg/day. [ 4 ] Some very important precautions that need to be taken include premedication by administering oral midazolam due to its anticonvulsive effect and avoiding inhalational agent such as sevoflurane which may provoke convulsions.…”

“…[ 4 ] Various measures to tackle hypoglycemia have been advocated which include concentrated glucose hydrocortisone 5 mg/kg 12 hourly IV, glucagon 0.1 mg/kg, and diazoxide 10–25 mg/kg/day. [ 4 ] Some very important precautions that need to be taken include premedication by administering oral midazolam due to its anticonvulsive effect and avoiding inhalational agent such as sevoflurane which may provoke convulsions. [ 5 6 ] We had avoided sevoflurane and used IV agents such as thiopentone and fentanyl instead as thiopentone has a better anticonvulsant action.…”