Nesidioblastosis associated with hyperglycemia in two squirrel monkeys (Saimiri sciureus)

Abstract

Nesidioblastosis associated with progressive weight loss and hyperglycemia was diagnosed in two mid-adult, wild-caught, male squirrel monkeys (Saimiri sciureus). Hyperglycemia, glucosuria, and abnormal glucose tolerance test results were found when the monkeys were presented for clinical evaluation for chronic weight loss, episodic dehydration, hypothermia, and lethargy. Immunohistochemical studies of the pancreatic tissue demonstrated that the proliferating endocrine cells stained predominantly glucagon-positive in the most severely affected monkey.

Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS): Review of the Literature of a Rare Cause of Hyperinsulinemic Hypoglycemia

“…Of interest, nesidioblastosis with or without hyperinsulinemic hypoglycemia was reported in animals. Cases of a 2-day-old Simmental calf (no hyperinsulinism) [ 365 ], young Beagle dogs (no hyperinsulinism) [ 366 ], a 6-year-old castrated male Australian Shepherd (hyperinsulinemic hypoglycemia) [ 367 ], old dogs (some with hypoglycemia and/or hyperinsulinism) [ 368 ], two squirrel monkeys (hyperglycemia with glucagon-reactive nesidioblastosis) [ 369 ], a cat (hyperinsulinemic hypoglycemia) [ 370 ], and several aged horses (no documented hyperinsulinism) [ 371 ] were found in the literature. If the pathophysiology and etiology of these morphological findings are similar to the ones in humans remains to be established.…”

Patologia comparada de Brachyteles arachnoides e Brachyteles hypoxantus (E. Geoffroy, 1806, Atelidae - Primates)

“…Saimiri sciureus (HARRIS et al,1979) Hepático e biliar Síndrome Dubin-Johnson humana Alouatta caraya; Leontopithecus Rosália (SCHULMAN et al, 1993;MARUFFO et al, 1996) Amiloidose secundária + quadros entéricos (GATESMAN, 1989;KING et al, 1996;SÁ, 1999) PNM (LLOYD et al, 1995;JUAN-SALLÉS et al, 2000) PNM (KING et al, 1996) PNM JUAN-SALLÉS et al, 2000) PNM (JUAN-SALLÉS et al, 1999). arachnoides.…”