2014
DOI: 10.4149/neo_2014_047
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Nesidioblastosis in adults

Abstract: The persistent hyperinsulinemic hypoglycemia may be caused either by a solitary tumor of the pancreas secreting excessive amount of insulin, known as insulinoma or, rarely, by nesidioblastosis. Nesidioblastosis is a rare cause of persistent hyperinsulinemic hypoglycemia in adults. The incidence of nesidioblastosis in adults is unknown, but it is generally thought to be very low. The β cell changes in adult nesidioblastosis suggest a dysregulation of the function of the cell. The cause of the functional dysregu… Show more

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Cited by 38 publications
(39 citation statements)
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“…Although post‐gastric surgery HH can be clearly distinguished by history, the distinction between postprandial HH and adult‐onset nesidioblastosis is not entirely clear. Nesidioblastosis is a histological term for islet hyperplasia associated with the continuous budding of islet cells from the ductal epithelium; therefore, the diagnosis of adult‐onset nesidioblastosis should not be made without the results of patients’ pancreatic histology. In real life, however, the diagnosis is often used to describe patients with features of NIPHS without histological confirmation.…”
Section: Discussionmentioning
confidence: 99%
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“…Although post‐gastric surgery HH can be clearly distinguished by history, the distinction between postprandial HH and adult‐onset nesidioblastosis is not entirely clear. Nesidioblastosis is a histological term for islet hyperplasia associated with the continuous budding of islet cells from the ductal epithelium; therefore, the diagnosis of adult‐onset nesidioblastosis should not be made without the results of patients’ pancreatic histology. In real life, however, the diagnosis is often used to describe patients with features of NIPHS without histological confirmation.…”
Section: Discussionmentioning
confidence: 99%
“…Although few systematic epidemiological studies were carried out to explore this condition, NIPHS is believed to be a very rare condition affecting <100 patients described in the literature during 1975–2014. The current nationwide survey identified 67 patients, excluding 33 with post‐gastric surgery HH.…”
Section: Discussionmentioning
confidence: 99%
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“…Distinction between adult nesidioblastosis and an occult insulinoma can be difficult, due to the similarity of the biochemical profile and some overlap in clinical presentation. The main clinical feature of nesidioblastosis is postprandial hypoglycemia, although fasting hypoglycemia has also been reported, as is typical in patients with insulinoma [9,10]. The definitive diagnosis relies on anatomical localization and histological examination of the pancreatic tissue [10,11].…”
Section: Discussionmentioning
confidence: 99%
“…In addition, it can be employed to distinguish between insulinoma and other very rare causes of hyperinsulinemic hypoglycemia such as nesidioblastosis. 30,31 This test can distinguish whether insulin secretion is localized (as in the case of insulinoma) or spread throughout pancreatic tissue as in nesidioblastosis. Several reports have mentioned high levels of sensitivity reaching in some cases 100%.…”
Section: Localization Of the Tumormentioning
confidence: 99%