Nesiritide — A New Agent For Acute Decompensated Heart Failure

Mathur, AG; Kairi, JK; Bb, Nayak

doi:10.1016/s0377-1237(05)80072-3

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Nesiritide is a recombinant human B-type natriuretic peptide (BNP), that causes vasodilation (including renal arteries), natriuresis, and RAA system inhibition [72]. Such mechanisms of action make it especially feasible for application in cardiac surgery.…”

Section: Nesiritidementioning

confidence: 99%

Alterations to Kidney Physiology during Cardiopulmonary Bypass—A Narrative Review of the Literature and Practical Remarks

Udzik,

Pacholewicz,

Biskupski

et al. 2023

JCM

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Introduction: According to different authors, cardiac surgery-associated acute kidney injury (CSA-AKI) incidence can be as high as 20–50%. This complication increases postoperative morbidity and mortality and impairs long-term kidney function in some patients. This review aims to summarize current knowledge regarding alterations to renal physiology during cardiopulmonary bypass (CPB) and to discuss possible nephroprotective strategies for cardiac surgeries. Relevant sections: Systemic and renal circulation, Vasoactive drugs, Fluid balance and Osmotic regulation and Inflammatory response. Conclusions: Considering the available scientific evidence, it is concluded that adequate kidney perfusion and fluid balance are the most critical factors determining postoperative kidney function. By adequate perfusion, one should understand perfusion with proper oxygen delivery and sufficient perfusion pressure. Maintaining the fluid balance is imperative for a normal kidney filtration process, which is essential for preserving the intra- and postoperative kidney function. Future directions: The review of the available literature regarding kidney function during cardiac surgery revealed a need for a more holistic approach to this subject.

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Section: Nesiritidementioning

confidence: 99%

Alterations to Kidney Physiology during Cardiopulmonary Bypass—A Narrative Review of the Literature and Practical Remarks

Udzik,

Pacholewicz,

Biskupski

et al. 2023

JCM

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Recent Trends in Peptide Drug Discovery and Development

Madge,

Muttenthaler

2024

Sustainability in Tides Chemistry

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The commercial success of peptide drugs, coupled with advances in peptide drug discovery and delivery technologies, medicinal chemistry strategies, and large-scale manufacturing, continues to drive peptide drug development, with peptide drugs accounting for ∼6% (US$ 90 billion) of the total global drug market revenue. Peptide drugs for metabolic disorders dominate the market, with insulin analogues and glucagon-like peptide 1 receptor (GLP-1R) agonists accounting for $46 and $24 billion in revenue, respectively, in 2023. This chapter provides an overview of the current peptide drug landscape, covers recently approved peptide drug classes, and discusses the latest trends in peptide drug development. Recent drug approvals are discussed in more detail and include peptide drugs derived from peptide hormones, natural products, and display technologies for diseases such as diabetes, obesity, achondroplastic dwarfism, and myasthenia gravis. The chapter further spotlights medicinal chemistry strategies instrumental in progressing these drugs to the clinic. The continuously evolving landscape of peptide drug development, driven by innovative discoveries and strategic medicinal chemistry approaches, underscores the essential place that peptide drugs hold within the global pharmaceutical market.

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Nesiritide — A New Agent For Acute Decompensated Heart Failure

Cited by 2 publications

References 9 publications

Alterations to Kidney Physiology during Cardiopulmonary Bypass—A Narrative Review of the Literature and Practical Remarks

Alterations to Kidney Physiology during Cardiopulmonary Bypass—A Narrative Review of the Literature and Practical Remarks

Recent Trends in Peptide Drug Discovery and Development

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