Nestin is a New Partner in Endothelial Colony Forming Cell Angiogenic Potential

Cras, Audrey; Larghero, Jérôme; Rossi, Elisa; Blandinières, Adeline; Gaussem, Pascale; Smadja, David M.

doi:10.1007/s12015-023-10587-1

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…ECFCs express stem cell markers CD34 and some endothelial markers (such as CD31, VE-cadherin, von Willebrand factor (vWF), VEGFR2) while lacking leukocytic markers (CD45 and CD14) [ 13 ]. ECFCs have been successfully isolated from various sources, including cord blood (CB) [ 14 ], peripheral blood (PB) [ 15 ], fat tissue [ 16 ], placenta (PL) [ 17 ], and lungs [ 18 ]. However, researchers have applied different approaches for isolation and cultivation of ECFCs [see review [ 19 ]].…”

Section: Introductionmentioning

confidence: 99%

Recent advances in endothelial colony-forming cells: from the transcriptomic perspective

Liu,

Lyons,

Ayu

et al. 2024

J Transl Med

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Endothelial colony-forming cells (ECFCs) are progenitors of endothelial cells with significant proliferative and angiogenic ability. ECFCs are a promising treatment option for various diseases, such as ischemic heart disease and peripheral artery disease. However, some barriers hinder the clinical application of ECFC therapeutics. One of the current obstacles is that ECFCs are dysfunctional due to the underlying disease states. ECFCs exhibit dysfunctional phenotypes in pathologic states, which include but are not limited to the following: premature neonates and pregnancy-related diseases, diabetes mellitus, cancers, haematological system diseases, hypoxia, pulmonary arterial hypertension, coronary artery diseases, and other vascular diseases. Besides, ECFCs are heterogeneous among donors, tissue sources, and within cell subpopulations. Therefore, it is important to elucidate the underlying mechanisms of ECFC dysfunction and characterize their heterogeneity to enable clinical application. In this review, we summarize the current and potential application of transcriptomic analysis in the field of ECFC biology. Transcriptomic analysis is a powerful tool for exploring the key molecules and pathways involved in health and disease and can be used to characterize ECFC heterogeneity.

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Section: Introductionmentioning

confidence: 99%

Recent advances in endothelial colony-forming cells: from the transcriptomic perspective

Liu,

Lyons,

Ayu

et al. 2024

J Transl Med

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The role of vasculature and angiogenesis in respiratory diseases

Ackermann,

Werlein,

Plucinski

et al. 2024

Angiogenesis

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In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension, IPF or lung cancer. The contribution of blood vessels and angiogenesis to lung regeneration, remodeling and disease progression has been increasingly appreciated. The vascular supply of the lung shows the peculiarity of dual perfusion of the pulmonary circulation (vasa publica), which maintains a functional blood-gas barrier, and the bronchial circulation (vasa privata), which reveals a profiled capacity for angiogenesis (namely intussusceptive and sprouting angiogenesis) and alveolar-vascular remodeling by the recruitment of endothelial precursor cells. The aim of this review is to outline the importance of vascular remodeling and angiogenesis in a variety of non-neoplastic and neoplastic acute and chronic respiratory diseases such as lung infection, COPD, lung fibrosis, pulmonary hypertension and lung cancer.

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