Nestin-positive/SOX2−negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice

Albright, Joshua E; Stojkovska, Iva; Rahman, Abir A; Brown, Connor J.; Morrison, Brad

doi:10.1016/j.neulet.2016.01.019

Cited by 30 publications

(17 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 months after the start of a 6 week treatment with tamoxifen, mice with Nestin -mediated tyrosine hydroxylase deletion showed lower numbers of tyrosine hydroxylase + neurons in substantia nigra, while no reduction was observed following Sox-2 -mediated excision. This finding further supports that Nestin-expressing cells regenerate dopaminergic neurons [ 101 ]. Previously discussed factors related to limitations of in vivo models may have influenced these controversial results that deserve further investigation and are highly relevant in search for therapeutic targets in Parkinson’s disease.…”

Section: Role Of Nestin + Cells In Pathogenesis Ansupporting

confidence: 83%

Nestin-expressing progenitor cells: function, identity and therapeutic implications

Bernal

Arranz

2018

Cell. Mol. Life Sci.

299

229

View full text Add to dashboard Cite

The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence of Nestin+ cells with progenitor and/or regulatory functions in a number of additional tissues, remarkably bone marrow. This review presents the current knowledge on the role of Nestin in essential stem cell functions, including self-renewal/proliferation, differentiation and migration, in the context of the cytoskeleton. We further discuss the available in vivo models for the study of Nestin+ cells and their progeny, their function and elusive nature in nervous system and bone marrow, and their potential mechanistic role and promising therapeutic value in preclinical models of disease. Future improved in vivo models and detection methods will allow to determine the true essence of Nestin+ cells and confirm their potential application as therapeutic target in a range of diseases.

show abstract

Section: Role Of Nestin + Cells In Pathogenesis Ansupporting

confidence: 83%

Nestin-expressing progenitor cells: function, identity and therapeutic implications

Bernal

Arranz

2018

Cell. Mol. Life Sci.

299

229

View full text Add to dashboard Cite

show abstract

“…Various endogenous factors have also been implicated in the modulation of SN neurogenesis. For example, Albright et al ( 2016 ) found that a population of nestin-positive cells contributes to dopaminergic neuron turnover in this brain structure (Albright et al, 2016 ). Furthermore, using a 6-OHDA mouse model, Padel et al ( 2016 ) also showed that platelet-derived growth factor (PDGF) can lead to the restoration of nigrostriatal fiber tracts (Padel et al, 2016 ).…”

Section: “Novel” Adult Neurogenic Zonesmentioning

confidence: 99%

Beyond the Hippocampus and the SVZ: Adult Neurogenesis Throughout the Brain

Jurkowski

Bettio

Woo

et al. 2020

Front. Cell. Neurosci.

152

109

View full text Add to dashboard Cite

Convincing evidence has repeatedly shown that new neurons are produced in the mammalian brain into adulthood. Adult neurogenesis has been best described in the hippocampus and the subventricular zone (SVZ), in which a series of distinct stages of neuronal development has been well characterized. However, more recently, new neurons have also been found in other brain regions of the adult mammalian brain, including the hypothalamus, striatum, substantia nigra, cortex, and amygdala. While some studies have suggested that these new neurons originate from endogenous stem cell pools located within these brain regions, others have shown the migration of neurons from the SVZ to these regions. Notably, it has been shown that the generation of new neurons in these brain regions is impacted by neurologic processes such as stroke/ischemia and neurodegenerative disorders. Furthermore, numerous factors such as neurotrophic support, pharmacologic interventions, environmental exposures, and stem cell therapy can modulate this endogenous process. While the presence and significance of adult neurogenesis in the human brain (and particularly outside of the classical neurogenic regions) is still an area of debate, this intrinsic neurogenic potential and its possible regulation through therapeutic measures present an exciting alternative for the treatment of several neurologic conditions. This review summarizes evidence in support of the classic and novel neurogenic zones present within the mammalian brain and discusses the functional significance of these new neurons as well as the factors that regulate their production. Finally, it also discusses the potential clinical applications of promoting neurogenesis outside of the classical neurogenic niches, particularly in the hypothalamus, cortex, striatum, substantia nigra, and amygdala.

show abstract

“…In contrast to studies on mammals, the results on juvenile chum salmon showed the presence of Nes+ cells not only in the matrix zones, but also outside them; in particular, in the parenchymal layers of the tegmentum, where the concentration of such elements was significantly higher than the number of Nes+ cells in the PVZ. Thus, the PZ of juvenile chum salmon should be considered in terms of the neurogenic potential comparable to that in PVZ, taking into account the fact that nestin is not expressed by mature neurons [40], being replaced by neuron-specific and glio-specific proteins in mature cells [41].…”

Section: Investigation Of Neuronal Progenitor Cells In the Tegmentum mentioning

confidence: 99%

Neural Stem Cells/Neuronal Precursor Cells and Postmitotic Neuroblasts in Constitutive Neurogenesis and After ,Traumatic Injury to the Mesencephalic Tegmentum of Juvenile Chum Salmon, Oncorhynchus keta

2020

View full text Add to dashboard Cite

The proliferation of neural stem cells (NSCs)/neuronal precursor cells (NPCs) and the occurrence of postmitotic neuroblasts in the mesencephalic tegmentum of intact juvenile chum salmon, Oncorhynchus keta, and at 3 days after a tegmental injury, were studied by immunohistochemical labeling. BrdU+ constitutive progenitor cells located both in the periventricular matrix zone and in deeper subventricular and parenchymal layers of the brain are revealed in the tegmentum of juvenile chum salmon. As a result of traumatic damage to the tegmentum, the proliferation of resident progenitor cells of the neuroepithelial type increases. Nestin-positive and vimentin-positive NPCs and granules located in the periventricular and subventricular matrix zones, as well as in the parenchymal regions of the tegmentum, are revealed in the mesencephalic tegmentum of juvenile chum salmon, which indicates a high level of constructive metabolism and constitutive neurogenesis. The expression of vimentin and nestin in the extracellular space, as well as additionally in the NSCs and NPCs of the neuroepithelial phenotype, which do not express nestin in the control animals, is enhanced during the traumatic process. As a result of the proliferation of such cells in the post-traumatic period, local Nes+ and Vim+ NPCs clusters are formed and become involved in the reparative response. Along with the primary traumatic lesion, which coincides with the injury zone, additional Nes+ and Vim+ secondary lesions are observed to form in the adjacent subventricular and parenchymal zones of the tegmentum. In the lateral tegmentum, the number of doublecortin-positive cells is higher compared to that in the medial tegmentum, which determines the different intensities and rates of neuronal differentiation in the sensory and motor regions of the tegmentum, respectively. In periventricular regions remote from the injury, the expression of doublecortin in single cells and their groups significantly increases compared to that in the damage zone.

show abstract

Nestin-positive/SOX2−negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice

Cited by 30 publications

References 31 publications

Nestin-expressing progenitor cells: function, identity and therapeutic implications

Nestin-expressing progenitor cells: function, identity and therapeutic implications

Beyond the Hippocampus and the SVZ: Adult Neurogenesis Throughout the Brain

Neural Stem Cells/Neuronal Precursor Cells and Postmitotic Neuroblasts in Constitutive Neurogenesis and After ,Traumatic Injury to the Mesencephalic Tegmentum of Juvenile Chum Salmon, Oncorhynchus keta

Contact Info

Product

Resources

About