Netrin-1: A Novel Universal Biomarker of Human Kidney Injury

Ramesh, Ganesan; Kwon, Oh Hun; Ahn, Kwangmi

doi:10.1016/j.transproceed.2009.11.040

Cited by 39 publications

(22 citation statements)

References 24 publications

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“…Urinary netrin-1 excretion was detected to increase dramatically in various AKI animal models as well as in AKI patients with different causes including ischemic AKI, radio-contrast-induced AKI, sepsisinduced AKI and drug-induced AKI. 22 In our study, no changes of netrin-1 level were detected in healthy volunteer urine samples. Urinary netrin-1 levels were significantly elevated as early as 1 h after ICU admission, while SCr levels elevated 24 h later, which indicated that urinary netrin-1 is a useful biomarker for the early diagnosis of AKI in septic patients.…”

Section: Discussioncontrasting

confidence: 53%

Urinary netrin-1 and KIM-1 as early biomarkers for septic acute kidney injury

Wang

Sun

et al. 2014

Renal Failure

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Background: Acute kidney injury (AKI) during sepsis is associated with poor outcome. However, diagnosis of AKI with serum creatinine (SCr) level change is neither highly sensitive nor specific. Therefore, identification of novel biomarkers for early diagnosis of AKI is desirable. Aims: To evaluate the capacity of combining urinary netrin-1 and human kidney injury molecule type 1 (KIM-1) in the early diagnosis of septic AKI. Methods: We prospectively recruited 150 septic patients from Jun 2011 to Jun 2013 at Zhejiang Provincial People's Hospital, China. SCr, urinary netrin-1, and KIM-1 levels were recorded at 0, 1, 3, 6, 24, and 48 h of ICU admission and compared between AKI and non-AKI patients. In addition, we investigated the prognostic value of netrin-1 and KIM-1 between non-survivors and survivors in septic AKI patients. Results: SCr levels started to show elevation after 24 h of ICU admission. However, netrin-1 levels increased significantly as early as 1 h, peaked at 3-6 h and remained elevated up to 48 h of ICU admission in septic AKI patients. KIM-1 increased significantly by 6 h, peaked at 24 h and remained significantly elevated until 48 h of ICU admission. Furthermore, we observed significant higher urinary KIM-1 levels at 24 h and 48 h in non-survivors compared to survivors in AKI patients. Conclusions: Our results suggest that both netrin-1 and KIM-1 are clinically useful as early biomarkers in the diagnosis of septic AKI. In addition, persistent elevation of urinary KIM-1 level may be associated with poor prognosis.

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Section: Discussioncontrasting

confidence: 53%

Urinary netrin-1 and KIM-1 as early biomarkers for septic acute kidney injury

Wang

Sun

et al. 2014

Renal Failure

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“…The authors came to the conclusion that Netrin-1 can serve as universal biomarker for AKI by demonstrating increased levels in patients with various forms of AKI. In detail, significantly higher levels were found in urine samples from patients with ischemic AKI, radiocontrast-induced AKI, sepsis-induced AKI, and drug-induced AKI in comparison with healthy controls (Ramesh et al, 2010b).…”

Section: Recently Emerging Potential Biomarkersmentioning

confidence: 87%

Biomarkers of kidney injury

2011

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“…Recently, a study showed that Netrin 1 may play an important role in the protection of diabetic nephropathy [127]. Above all, Netrin-1 can be used as an early diagnostic marker of AKI, but urinary Netrin-1 was significantly higher in AKI patients caused by ischemia, contrast agents, drugs, and sepsis than that in normal healthy people [128]. Further studies are still needed to clarify the underlying mechanism of this protective function.…”

Section: Netrin-1mentioning

confidence: 99%

Early Predictors of Acute Kidney Injury: A Narrative Review

Liu

Guan

et al. 2016

Kidney Blood Press Res

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Accompanied with the broad application of interventional therapy, the incidence of acute kidney injury (AKI) has been recently increasing in clinical renal medicine. The pathogenesis of AKI is diverse and complex. In the context of the requirements for the diagnosis and treatment of a renal disorder, a large number of studies have explored biological markers and their usefulness to the early diagnosis and treatment of AKI, including glomerular injury, renal tubular injury, and others. These biomarkers provide an important basis for early monitoring of AKI, but are still not quite sufficient. More ideal biomarkers are needed to be identified. Therefore, future studies are necessary to explore more effective biomarkers for AKI clinical practice, which would play an important role in the early diagnosis and intervention treatment of AKI. This review summarizes the important biomarkers identified by previous studies and aims to highlight the advancements that might provide new methods for early clinical diagnosis and effective therapeutic options, along with prediction of response to treatment for AKI.

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Netrin-1: A Novel Universal Biomarker of Human Kidney Injury

Cited by 39 publications

References 24 publications

Urinary netrin-1 and KIM-1 as early biomarkers for septic acute kidney injury

Urinary netrin-1 and KIM-1 as early biomarkers for septic acute kidney injury

Biomarkers of kidney injury

Early Predictors of Acute Kidney Injury: A Narrative Review

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