Netrin-1 promotes liver regeneration possibly by facilitating vagal nerve repair after partial hepatectomy in mice

Wang, Zongding; Jiang, Tiemin; Aji, Tuerganaili; Aimulajiang, Kalibixiati; Liu, Yanshi; Lv, Guodong; Wen, Hao

doi:10.1016/j.cellsig.2021.110227

Cited by 11 publications

(6 citation statements)

References 39 publications

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“…Subsequently, exogenous supplementation of Netrin-1 was administered in the tail vein of mice and positive expression of GAP-43 was observed in the liver tissue 1 week after surgery, as evidenced by the nerve regeneration in the liver 1 week after Netrin-1 administration. Subsequent detection of positive anti-choline acetyltransferase (ChAT) in the liver tissue further confirmed that Netrin-1 promotes vagal nerve regeneration in the liver (Wang et al, 2022). It is certainly a revelation to us that the research and development of exogenous targeted neurological drugs for postliver transplant patients point to pharmaceutical innovation that will help in the rehabilitation of liver transplant patients with neurological regeneration.…”

Section: Reinnervation Of the Parasympathetic Plexus In The Transplan...mentioning

confidence: 90%

Nerve regeneration in transplanted organs and tracer imaging studies: A review

Huang

Manyande

et al. 2022

Front. Bioeng. Biotechnol.

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The technique of organ transplantation is well established and after transplantation the patient might be faced with the problem of nerve regeneration of the transplanted organ. Transplanted organs are innervated by the sympathetic, parasympathetic, and visceral sensory plexuses, but there is a lack of clarity regarding the neural influences on the heart, liver and kidneys and the mechanisms of their innervation. Although there has been considerable recent work exploring the potential mechanisms of nerve regeneration in organ transplantation, there remains much that is unknown about the heterogeneity and individual variability in the reinnervation of organ transplantation. The widespread availability of radioactive nerve tracers has also made a significant contribution to organ transplantation and has helped to investigate nerve recovery after transplantation, as well as providing a direction for future organ transplantation research. In this review we focused on neural tracer imaging techniques in humans and provide some conceptual insights into theories that can effectively support our choice of radionuclide tracers. This also facilitates the development of nuclear medicine techniques and promotes the development of modern medical technologies and computer tools. We described the knowledge of neural regeneration after heart transplantation, liver transplantation and kidney transplantation and apply them to various imaging techniques to quantify the uptake of radionuclide tracers to assess the prognosis of organ transplantation. We noted that the aim of this review is both to provide clinicians and nuclear medicine researchers with theories and insights into nerve regeneration in organ transplantation and to advance imaging techniques and radiotracers as a major step forward in clinical research. Moreover, we aimed to further promote the clinical and research applications of imaging techniques and provide clinicians and research technology developers with the theory and knowledge of the nerve.

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Section: Reinnervation Of the Parasympathetic Plexus In The Transplan...mentioning

confidence: 90%

Nerve regeneration in transplanted organs and tracer imaging studies: A review

Huang

Manyande

et al. 2022

Front. Bioeng. Biotechnol.

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“…The UNC5 family of netrin receptors (UNC5C and 5D) is involved in axon guidance and mediates axon repulsion of neuronal growth cones in the developing nervous system(33). Of particular interest is that netrin-1 was found to stimulate the regeneration of the hepatic vagal nerve and the proliferation of hepatocytes in mice following hepatectomy(34). Thus, our initial findings from single-nucleus RNA sequencing provides significant information regarding their potential implications for a range of physiological processes.…”

Section: Discussionmentioning

confidence: 99%

Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice

Hwang,

Lee,

Okada

et al. 2024

Preprint

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The visceral organ-brain axis, mediated by vagal sensory neurons in the vagal nerve ganglion, is essential for maintaining various physiological functions. These vagal sensory neurons relay interoceptive signals from visceral organs to the medulla. In this study, we investigate the influence of the loss of the liver-brain axis on energy balance, glucose homeostasis, and hepatic steatosis in mice under obesogenic conditions. A subset of vagal sensory neurons innervating the liver is located in both the left and right ganglia, projecting centrally to the nucleus of the tractus solitarius, area postrema, and dorsal motor nucleus of the vagus, and peripherally to the periportal areas in the liver. Ablation of the liver-brain axis via caspase-induced selective destruction of advillin-positive neurons prevents diet-induced obesity in male and female mice, and these outcomes are associated with increased energy expenditure. Although males and females exhibit improved glucose homeostasis following disruption of the liver-brain axis, only male mice display increased insulin sensitivity. Furthermore, loss of the liver-brain axis limits the progression of hepatic steatosis in male and female mice fed a steatogenic diet. Therefore, modulation of the liver-brain axis may present a therapeutic strategy for restoring lipid metabolism and glucose homeostasis in obesity and diabetes.

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“…Besides, netrin-1 accelerates liver regeneration after partial hepatectomy in mice, and the potential mechanism is related to the promotion of vagus nerve repair and regeneration. 331 Therefore, leptin targeting the gut-liver-brain axis is supposed to become a promising drug in the future.…”

Section: Mechanisms Linking the Liver-brain Axismentioning

confidence: 99%

Gut liver brain axis in diseases: the implications for therapeutic interventions

Yan,

Man,

Sun

et al. 2023

Sig Transduct Target Ther

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Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough progress has been made in the gut liver brain axis, mainly through understanding its formation mechanism and increasing treatment strategies. In this review, we discuss various complex networks including barrier permeability, gut hormones, gut microbial metabolites, vagus nerve, neurotransmitters, immunity, brain toxic metabolites, β-amyloid (Aβ) metabolism, and epigenetic regulation in the gut-liver-brain axis. Some therapies containing antibiotics, probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT), polyphenols, low FODMAP diet and nanotechnology application regulate the gut liver brain axis. Besides, some special treatments targeting gut-liver axis include farnesoid X receptor (FXR) agonists, takeda G protein-coupled receptor 5 (TGR5) agonists, glucagon-like peptide-1 (GLP-1) receptor antagonists and fibroblast growth factor 19 (FGF19) analogs. Targeting gut-brain axis embraces cognitive behavioral therapy (CBT), antidepressants and tryptophan metabolism-related therapies. Targeting liver-brain axis contains epigenetic regulation and Aβ metabolism-related therapies. In the future, a better understanding of gut-liver-brain axis interactions will promote the development of novel preventative strategies and the discovery of precise therapeutic targets in multiple diseases.

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Netrin-1 promotes liver regeneration possibly by facilitating vagal nerve repair after partial hepatectomy in mice

Cited by 11 publications

References 39 publications

Nerve regeneration in transplanted organs and tracer imaging studies: A review

Nerve regeneration in transplanted organs and tracer imaging studies: A review

Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice

Gut liver brain axis in diseases: the implications for therapeutic interventions

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