Netrin-1 promotes the vasculogenic capacity of human adipose-derived stem cells

Luo, Moulun; Zhao, Jianwen; Gao, Xue-mei

doi:10.1007/s10561-022-10038-0

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…The modified cells showed greater proliferative activity and pro-angiogenic properties. Overexpression of netrin-1 may be a promising strategy for the treatment of ischemic diseases in the future [ 110 ].…”

Section: Bioengineered Ad-mscs In Regenerative Medicinementioning

confidence: 99%

Adipose-Derived Mesenchymal Stromal Cells in Basic Research and Clinical Applications

Czerwiec

Zawrzykraj

Deptuła

et al. 2023

IJMS

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Adipose-derived mesenchymal stromal cells (AD-MSCs) have been extensively studied in recent years. Their attractiveness is due to the ease of obtaining clinical material (fat tissue, lipoaspirate) and the relatively large number of AD-MSCs present in adipose tissue. In addition, AD-MSCs possess a high regenerative potential and immunomodulatory activities. Therefore, AD-MSCs have great potential in stem cell-based therapies in wound healing as well as in orthopedic, cardiovascular, or autoimmune diseases. There are many ongoing clinical trials on AD-MSC and in many cases their effectiveness has been proven. In this article, we present current knowledge about AD-MSCs based on our experience and other authors. We also demonstrate the application of AD-MSCs in selected pre-clinical models and clinical studies. Adipose-derived stromal cells can also be the pillar of the next generation of stem cells that will be chemically or genetically modified. Despite much research on these cells, there are still important and interesting areas to explore.

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Section: Bioengineered Ad-mscs In Regenerative Medicinementioning

confidence: 99%

Adipose-Derived Mesenchymal Stromal Cells in Basic Research and Clinical Applications

Czerwiec

Zawrzykraj

Deptuła

et al. 2023

IJMS

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“…They also inhibited caspase-1 and IL-1β pathways, protecting ECs and cardiomyocytes against cell death [34]. Netrin-1 overexpression increased the vasculogenic capacity of ASCs by inducing metalloproteinase (MMP)-2 and MMP-9, VEGF, and placental growth factor (PlGF) [35] (Figure 2).…”

Section: Adipose-derived Stem Cells Preserve Ec Function In Preclinic...mentioning

confidence: 99%

Aging and Metabolic Reprogramming of Adipose-Derived Stem Cells Affect Molecular Mechanisms Related to Cardiovascular Diseases

Holvoet

2023

Cells

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We performed a systematic search of the PubMed database for English-language articles related to the function of adipose-derived stem cells in the pathogenesis of cardiovascular diseases. In preclinical models, adipose-derived stem cells protected arteries and the heart from oxidative stress and inflammation and preserved angiogenesis. However, clinical trials did not reiterate successful treatments with these cells in preclinical models. The low success in patients may be due to aging and metabolic reprogramming associated with the loss of proliferation capacity and increased senescence of stem cells, loss of mitochondrial function, increased oxidative stress and inflammation, and adipogenesis with increased lipid deposition associated with the low potential to induce endothelial cell function and angiogenesis, cardiomyocyte survival, and restore heart function. Then, we identify noncoding RNAs that may be mechanistically related to these dysfunctions of human adipose-derived stem cells. In particular, a decrease in let-7, miR-17-92, miR-21, miR-145, and miR-221 led to the loss of their function with obesity, type 2 diabetes, oxidative stress, and inflammation. An increase in miR-34a, miR-486-5p, and mir-24-3p contributed to the loss of function, with a noteworthy increase in miR-34a with age. In contrast, miR-146a and miR-210 may protect stem cells. However, a systematic analysis of other noncoding RNAs in human adipose-derived stem cells is warranted. Overall, this review gives insight into modes to improve the functionality of human adipose-derived stem cells.

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Netrin-1 promotes the vasculogenic capacity of human adipose-derived stem cells

Cited by 2 publications

References 49 publications

Adipose-Derived Mesenchymal Stromal Cells in Basic Research and Clinical Applications

Adipose-Derived Mesenchymal Stromal Cells in Basic Research and Clinical Applications

Aging and Metabolic Reprogramming of Adipose-Derived Stem Cells Affect Molecular Mechanisms Related to Cardiovascular Diseases

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