Netrin-1 signaling mediates NO-induced glial precursor migration and accumulation

Spatio-temporal deleted in colorectal cancer (DCC) and netrin-1 expression in human foetal brain development

“…In the developing telencephalon netrin‐1 interacts with alpha3beta1‐integrin and regulates the migration of interneurones through the marginal zone (MZ) [9]. Recent in vitro findings show that rhesus monkey‐derived A2B5‐positive glial progenitors expressing netrin‐1 and DCC are associated with increased cellular migration and accumulation [10]. Besides their roles in neuronal and astroglial development, netrin‐1 and DCC are also involved in oligodendroglial myelin regulation [11,12].…”

Characterization of glial-restricted precursors from rhesus monkey embryonic stem cells

“…Thus, these newly purified GRP cells are valuable in determining the mechanism of glial lineage cell fate. Interestingly, the GRP cells also provide a good model to study cell migration in vitro [ 29 ].…”

The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled

“…Hence, a thorough understanding of the molecules involved in the process of glia migration may contribute to the development of therapeutics for these pathologies. Research progress in recent years has revealed the involvement of chemotropic cues in glia migration (von Hilchen et al, 2010; Chen et al, 2010; Spassky et al, 2002; Kinrade et al, 2001; Liu et al, 2012). Netrins, a class of secreted laminin-related extracellular proteins, have been described as chemotropic guidance cues for axons and migrating cells during neural development (Lai Wing Sun et al, 2011; Harris et al, 1996; Ishii et al, 1992; Kennedy et al, 1994; Mitchell et al, 1996; Serafini et al, 1994).…”