Network Analysis of Murine Cortical Dynamics Implicates Untuned Neurons in Visual Stimulus Coding

Levy, Maayan; Sporns, Olaf; MacLean, Jason N.

doi:10.1016/j.celrep.2020.03.047

Cited by 27 publications

(22 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also observed grating-responsive neurons that did not exhibit classic tuning characteristics ( Figure 4A, right). 34,35 In this later ll example, the neuron selectively responded to a subset or orientations for the lowest spatial frequency presented as well as for high spatial frequencies, but not to spatial frequencies of 0.1 cycles/ , similar to a previous report. 34 We quantified the relative preference for grating versus natural scene stimuli on a neuron-by-neuron basis as the natural scene-grating (NG) preference index.…”

Section: Impact Of Experience On Natural Scene Discriminationsupporting

confidence: 88%

Development of Natural Scene Representation in Primary Visual Cortex Requires Early Postnatal Experience

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Impact Of Experience On Natural Scene Discriminationsupporting

confidence: 88%

Development of Natural Scene Representation in Primary Visual Cortex Requires Early Postnatal Experience

et al. 2021

View full text Add to dashboard Cite

show abstract

“…We also observed grating responsive neurons that did not exhibit classic tuning characteristics (Fig. 4A, right) [34,35]. In this later example, the neuron selectively responded to a subset or orientations for the lowest spatial frequency presented as well as for high spatial frequencies, but not to spatial frequencies of 0.1 cycles/°, similar to a previous report [34].…”

Section: Impact Of Experience On Natural Scene Discriminationsupporting

confidence: 88%

Development of natural scene representation in primary visual cortex requires early postnatal experience

Kowalewski

Kauttonen

Stan

et al. 2020

Preprint

View full text Add to dashboard Cite

The development of the visual system is known to be shaped by early-life experience. To identify response properties that contribute to enhanced natural scene representation, we performed calcium imaging of excitatory neurons in the primary visual cortex (V1) of awake mice raised in three different conditions (standard-reared, dark-reared, and delayed-visual experience) and compared neuronal responses to natural scene features relative to simpler grating stimuli that varied in orientation and spatial frequency. We assessed population selectivity in V1 using decoding methods and found that natural scene discriminability increased by 75% between the ages of 4 to 6 weeks. Both natural scene and grating discriminability were higher in standard-reared animals compared to those raised in the dark. This increase in discriminability was accompanied by a reduction in the number of neurons that responded to low-spatial frequency gratings. At the same time there was an increase in neuronal preference for natural scenes. Light exposure restricted to a 2-4 week window during adulthood did not induce improvements in natural scene nor in grating stimulus discriminability. Our results demonstrate that experience reduces the number of neurons required to effectively encode grating stimuli and that early visual experience enhances natural scene discriminability by directly increasing responsiveness to natural scene features.

show abstract

“…Not all neurons are well tuned to grating stimuli, yet such neurons can contribute to visual processing ( Levy et al, 2020 ). Therefore, we expanded our analysis to include all tracked neurons, regardless of their responsiveness or tuning characteristics to grating stimuli.…”

Section: Resultsmentioning

confidence: 99%

Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex

Jeon

Fuchs

Chase

et al. 2022

eLife

View full text Add to dashboard Cite

Transient dark exposure, typically 7–10 days in duration, followed by light reintroduction is an emerging treatment for improving the restoration of vision in amblyopic subjects whose occlusion is removed in adulthood. Dark exposure initiates homeostatic mechanisms that together with light-induced changes in cellular signaling pathways result in the re-engagement of juvenile-like plasticity in the adult such that previously deprived inputs can gain cortical territory. It is possible that dark exposure itself degrades visual responses, and this could place constraints on the optimal duration of dark exposure treatment. To determine whether eight days of dark exposure has a lasting negative impact on responses to classic grating stimuli, neural activity was recorded before and after dark exposure in awake head-fixed mice using two-photon calcium imaging. Neural discriminability, assessed using classifiers, was transiently reduced following dark exposure; a decrease in response reliability across a broad range of spatial frequencies likely contributed to the disruption. Both discriminability and reliability recovered. Fixed classifiers were used to demonstrate that stimulus representation rebounded to the original, pre-deprivation state, thus dark exposure did not appear to have a lasting negative impact on visual processing. Unexpectedly, we found that dark exposure significantly stabilized orientation preference and signal correlation. Our results reveal that natural vision exerts a disrupting influence on the stability of stimulus preference for classic grating stimuli and, at the same time, improves neural discriminability for both low and high-spatial frequency stimuli.

show abstract

Network Analysis of Murine Cortical Dynamics Implicates Untuned Neurons in Visual Stimulus Coding

Cited by 27 publications

References 55 publications

Development of Natural Scene Representation in Primary Visual Cortex Requires Early Postnatal Experience

Development of Natural Scene Representation in Primary Visual Cortex Requires Early Postnatal Experience

Development of natural scene representation in primary visual cortex requires early postnatal experience

Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex

Contact Info

Product

Resources

About