Network analysis of the depressive symptom profiles in Asian patients with depressive disorders: Findings from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP‐AD)

Park, Seon Cheol; Jang, Eun Young; Xiang, Yu Tao; Kanba, Shigenobu; Kato, Takahiro A.; Chong, Mian‐Yoon; Lin, Shih‐Ku; Yang, Shuyu; Grover, Sandeep; Kallivayalil, Roy Abraham; Udomratn, Pichet; Chee, Kok Yoon; Tanra, Andi Jayalangkara; Tan, C.H.; Sim, Kang; Sartorius, Norman; Park, Yong Chon; Shinfuku, Naotaka

doi:10.1111/pcn.12989

Cited by 20 publications

(14 citation statements)

References 62 publications

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“…This result is not entirely consistent with the typical symptoms of depressive episodes as defined by the tenth edition of the International Statistical Classification of Diseases and Related Health Problems, namely depressed mood, loss of interest, and reduced energy. 25 Thus, using data from the CRESCEND study, 7 this study aimed to estimate the serial changes in the centralities and network structures of the items of the 17-item Hamilton Depression Rating Scale (HAMD) 26,27 in a large sample of South Korean patients with DSM-defined depressive disorders.…”

Section: Network Analysis Of the Symptoms Of Depressive Disorders Over The Course Of Therapy: Changes In Centrality Measuresmentioning

confidence: 99%

Network Analysis of the Symptoms of Depressive Disorders Over the Course of Therapy: Changes in Centrality Measures

Park

Kim

et al. 2021

Psychiatry Investig

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Objective Network analysis can be used in terms of a novel psychopathological approach for depressive syndrome. We aimed to estimate the successive network structures of depressive symptoms in patients with depressive disorder using data from the Clinical Research Center for Depression study.Methods We enrolled 1,152 South Korean adult patients with depressive disorders who were beginning treatment for first-onset or recurrent depressive episodes. We examined the network structure of the severities of the items on the Hamilton Depression Rating Scale (HAMD) at baseline and at weeks 2, 12, 25, and 52. The node strength centrality of all the HAMD items at baseline and at week 2, 12, 25, and 52 in terms of network analysis.Results In the severity networks, the anxiety (psychic) item was the most centrally situated in the initial period (baseline and week 2), while loss of weight was the most centrally situated item in the later period (weeks 25 and 52). In addition, the number of strong edges (i.e., edges representing strong correlations) increased in the late period compared to the initial period.Conclusion Our findings support a period-specific and symptom-focused therapeutic approach that can provide complementary information to the unidimensional total HAMD score.

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Section: Network Analysis Of the Symptoms Of Depressive Disorders Over The Course Of Therapy: Changes In Centrality Measuresmentioning

confidence: 99%

Network Analysis of the Symptoms of Depressive Disorders Over the Course of Therapy: Changes in Centrality Measures

Park

Kim

et al. 2021

Psychiatry Investig

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“…Previous studies have indicated that there could be a large gap between the development of evidence-based guidelines and their implementation in clinical settings, 18,19,[21][22][23] and that a combination of several guideline dissemination and implementation strategies aimed at healthcare professionals has failed to reduce antipsychotic polypharmacy for schizophrenia out-patients. 24 The pathway from evidence to guidelines is highly developed, but the development of guideline implementation strategies has been insufficient and examined in only a few studies.…”

Section: Discussionmentioning

confidence: 99%

A dissemination and education programme to improve the clinical behaviours of psychiatrists in accordance with treatment guidelines for schizophrenia and major depressive disorders: the Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE) project

et al. 2022

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Background Clinical practice guidelines for schizophrenia and major depressive disorder have been published. However, these have not had sufficient penetration in clinical settings. We developed the Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE) project as a dissemination and education programme for psychiatrists. Aims The aim of this study is to assess the effectiveness of the EGUIDE project on the subjective clinical behaviour of psychiatrists in accordance with clinical practice guidelines before and 1 and 2 years after participation in the programmes. Method A total of 607 psychiatrists participated in this study during October 2016 and March 2019. They attended both 1-day educational programmes based on the clinical practice guidelines for schizophrenia and major depressive disorder, and answered web questionnaires about their clinical behaviours before and 1 and 2 years after attending the programmes. We evaluated the changes in clinical behaviours in accordance with the clinical practice guidelines between before and 2 years after the programme. Results All of the scores for clinical behaviours in accordance with clinical practice guidelines were significantly improved after 1 and 2 years compared with before attending the programmes. There were no significant changes in any of the scores between 1 and 2 years after attending. Conclusions All clinical behaviours in accordance with clinical practice guidelines improved after attending the EGUIDE programme, and were maintained for at least 2 years. The EGUIDE project could contribute to improved guideline-based clinical behaviour among psychiatrists.

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“…The first is the solvation energy, and the second is the potential energy in a vacuum. ∆E (MM-PBSA) = ∆E MM + ∆G solvation (1) ∆E MM and ∆G solvation are the vacuum potential energy and free solvation energy in Equation (1), respectively. The molecular mechanical energy (∆E MM ) is obtained from the electrostatic component (∆E ele ) and the van der Waals interaction (∆E vdW ).…”

Section: Molecular Mechanics/poisson-boltzmann Surface Area (Mm-pbsa) Calculationsmentioning

confidence: 99%

“…Generally, there are several situations and conditions that stimulate stress to vary degrees in humans [ 1 ]. However, anxiety and depression are principal reaction conditions that induce stress and stress disorders or complications [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Quercetin and/or Ascorbic Acid Modulatory Effect on Phenobarbital-Induced Sleeping Mice Possibly through GABAA and GABAB Receptor Interaction Pathway

et al. 2021

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Background: Depressive disorder is a recurrent illness that affects large numbers of the general population worldwide. In recent years, the goal of depression treatment has moved from symptomatic response to that of full remission. However, treatment-resistant depression is a major challenge in the treatment of depression or depression-related disorders. Consensus opinion, therefore, suggests that effective combined aggressive initial treatment is the most appropriate strategy. Objectives: This study aimed to evaluate the effects of quercetin (QUR) and/or ascorbic acid (AA) on Phenobarbital-induced sleeping mice. Methods: QUR (50 mg/kg) and/or AA (25 mg/kg) with or without intraperitoneally pre-treated with GABA receptor agonist (diazepam: 2 mg/kg, i.p.) or antagonist (Flumazenil: 2.5 mg/kg, i.p.) to underscore the effects, as well as the possible involvement of the GABA receptor in the modulatory action of QUR and AA in sleeping mice. Additionally, an in silico study was undertaken to predict the involvement of GABA receptors in the sleep mechanism. Results: Findings suggest that the pretreatment of QUR and AA modulated the onset and duration of action of the standard drugs in experimental animals. The acute administration of QUR and/or AA significantly (p < 0.05) reversed the DZP-mediated onset of action and slightly reversed the duration of sleep time in comparison to the vehicle (control) group. A further combination of QUR or AA with the FLU resulted in an enhancement of the onset of action while reducing the duration of action, suggesting a FLU-like effect on the test animals. In in silico studies, AA and QUR showed good to moderate binding affinities with GABAA and GABAB receptors. Conclusions: Both QUR and AA produced a stimulatory-like effect on mice, possibly through the GABAA and GABAB receptor interaction pathways. Further studies are necessary to verify this activity and clarify the exact mechanism of action(s) involved.

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Network analysis of the depressive symptom profiles in Asian patients with depressive disorders: Findings from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP‐AD)

Cited by 20 publications

References 62 publications

Network Analysis of the Symptoms of Depressive Disorders Over the Course of Therapy: Changes in Centrality Measures

Network Analysis of the Symptoms of Depressive Disorders Over the Course of Therapy: Changes in Centrality Measures

A dissemination and education programme to improve the clinical behaviours of psychiatrists in accordance with treatment guidelines for schizophrenia and major depressive disorders: the Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE) project

Quercetin and/or Ascorbic Acid Modulatory Effect on Phenobarbital-Induced Sleeping Mice Possibly through GABAA and GABAB Receptor Interaction Pathway

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