Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Abstract

Background Oral squamous cell carcinoma (OSCC) is one of the malignant tumors with a poor prognosis. Periodontitis (PD is considered a high-risk factor for OSCC, but the genetic mechanism is rarely studied. This study aims to link OSCC and PD by identifying common differentially expressed miRNAs (Co-DEmiRNAs), their related genes (Hub genes), transcription factors (TFs), signaling pathways, enrichment functions, and compounds, and searching for genetic commonalities. Methods The miRNAs expression datasets of OSCC and PD were searched from the GEO database. The miRNA and related crosstalk mechanism between OSCC and PD was obtained through a series of analyses. Results hsa-mir-497, hsa-mir-224, hsa-mir-210, hsa-mir-29c, hsa-mir-486-5p, and hsa-mir-31are the top miRNA nodes in Co-DEmiRNA-Target networks. The most significant candidate miRNA dysregulation genes are ZNF460, FBN1, CDK6, BTG2, and CBX6, while the most important dysregulation TF includes HIF1A, TP53, E2F1, MYCN, and JUN. 5-fluorouracil, Ginsenoside, Rh2, and Formaldehyde are the most correlated compounds. Enrichment analysis revealed cancer-related pathways and so on. Conclusions The comprehensive analysis reveals the interacting genetic and molecular mechanism between OSCC and PD, linking both and providing a foundation for future basic and clinical research.

Arecoline promotes Akt‐c‐Myc‐driven aerobic glycolysis in esophageal epithelial cells

“…However, the specific type of ubiquitin chain and E3 ubiquitin ligase that mediated c‐Myc degradation needs further exploration. Based on previous research findings, arecoline is a compound carcinogen that induces genetic mutations, DNA damage, and epigenetic abnormalities in somatic cells 45–48 . The changes in glycolytic pathways induced by arecoline in esophageal epithelial cells in our study may also involve genetic mutations or epigenetic abnormalities in esophageal epithelial cells.…”

Baicalin induces ferroptosis in oral squamous cell carcinoma by suppressing the activity of FTH1

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The application of drug behavior management methods in the treatment of dental fear and oral diseases in children: A review

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