How should a cluster be designed to foster the innovativeness of its members? In this article, we view self-aware and organised clusters as “meta-organisations” which can deliberately shape their internal structures through design-based interventions. To formulate interventions for cluster design fostering its innovativeness, we adopt a methodology combining a systematic literature review and a design-oriented synthesis. We distinguish between six cluster business model elements: actors and their roles, resources and capabilities, value flows, governance, value propositions and value-creating activities. To gain insight into the properties of these elements conducive to cluster innovativeness, we review literature at the intersection of cluster, meta-organisation, business model and innovation studies. Our study allows to consolidate the extant research into “organised” clustering and the drivers of the cluster actors’ innovativeness. It also helps identify several important unanswered questions in the literature and to suggest potentially fruitful directions for further work.