Network controllability solutions for computational drug repurposing using genetic algorithms

Abstract

Control theory has seen recently impactful applications in network science, especially in connections with applications in network medicine. A key topic of research is that of finding minimal external interventions that offer control over the dynamics of a given network, a problem known as network controllability. We propose in this article a new solution for this problem based on genetic algorithms. We tailor our solution for applications in computational drug repurposing, seeking to maximize its use of FDA-approved drug targets in a given disease-specific protein-protein interaction network. We demonstrate our algorithm on several cancer networks and on several random networks with their edges distributed according to the Erdős–Rényi, the Scale-Free, and the Small World properties. Overall, we show that our new algorithm is more efficient in identifying relevant drug targets in a disease network, advancing the computational solutions needed for new therapeutic and drug repurposing approaches.

Multiobjective Optimization of Chemically Assisted Magnetic Abrasive Finishing (MAF) on Inconel 625 Tubes Using Genetic Algorithm: Modeling and Microstructural Analysis

“…In present study, a total of five input parameters and three output parameters were considered for the design of the experiment. Previous studies have proved that soft computing techniques provide more reliable optimum results in the case of multiobjective optimization [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. GA is an inbuilt tool in MATLAB, which make it friendlier for users.…”

“…As per the SCOPUS database, more than sixty-four thousand articles have been published to date. Researchers have successfully implemented GA in various disciplines, such as machining [ 35 ], drug repurposing [ 36 ], automobiles [ 37 ], earth work activities [ 38 ], transportation [ 39 ], antenna [ 40 ], energy planning [ 41 ], electric vehicle [ 42 ], structural design [ 43 ], etc. Figure 8 represents the genetic algorithm flow chart.…”

Module control of network analysis in psychopathology

“…It takes the network system as a whole, makes inherent assumptions about the network system’s operating mechanisms and looks for the critical nodes that driving the network state. 18 To date, network controllability theory has been applied in various biological fields, protein networks, 23 , 24 , 25 brain networks, 26 , 27 , 28 , 29 cancer, 30 , 31 , 32 precise medication, 33 and drug repurposing, 34 , 35 it makes possible for researchers to control the behavior of large-scale networks.…”