“…The biophysical realism of the causal claims will depend on the validity of the dynamical model, which can be determined through methods of system identification ( Srivastava et al, 2020 ). Finally, we note that within this setup, one can consider alternative dynamical models ( Cornelius et al, 2013 ; Morrison and Kutz, 2021 ; Zañudo et al, 2017 ), alternative connectome definitions ( Karrer et al, 2020 ; Stiso et al, 2020 ; Yan et al, 2017 ), directed connections ( Kim et al, 2018 ), control of edges rather than nodes ( Becker et al, 2020 ), and alternative modulating variables including gray matter, neurotransmitters, and cognitive or dynamical state ( Cornblath et al, 2020 ; Jamalabadi et al, 2021 ; Scheid et al, 2020 ; Singleton et al, 2021 ; Zarkali et al, 2021 ).…”