“…Samples from different sources (manufacturers and/or batches) could be readily differentiated using EA/IRMS. Phillips et al [26] also reported on research conducted by Jasper on differentiating between pharmaceutical products from different batches using EA/IRMS. Bommer et al [50] reported the differentiation of batches of diazepam using IRMS.…”
Section: Pharmacology Applicationsmentioning
confidence: 99%
“…The review also addressed the identification and quantification of biodegradation processes and fractionation effects on a range of environmental samples. Kalin, as cited by Phillips et al [26], discussed the analysis of samples often found as contaminants in the environment, including methyl tert-butyl ether (MTBE) found in petrol and trichloroethane (TCE). Environmental effects on the isotopic composition of these samples were also evaluated.…”
“…The Network aims to raise the awareness of the potential for IRMS in forensic science and to encourage collaboration between various scientific disciplines. The Network held its first conference in September 2002 (Kent, UK) from which three working groups were formed: Explosives, Drugs and General Forensics [26]. A summary of the conference discussions and presentations is available [26].…”
Section: General Forensic Science Applicationsmentioning
“…Samples from different sources (manufacturers and/or batches) could be readily differentiated using EA/IRMS. Phillips et al [26] also reported on research conducted by Jasper on differentiating between pharmaceutical products from different batches using EA/IRMS. Bommer et al [50] reported the differentiation of batches of diazepam using IRMS.…”
Section: Pharmacology Applicationsmentioning
confidence: 99%
“…The review also addressed the identification and quantification of biodegradation processes and fractionation effects on a range of environmental samples. Kalin, as cited by Phillips et al [26], discussed the analysis of samples often found as contaminants in the environment, including methyl tert-butyl ether (MTBE) found in petrol and trichloroethane (TCE). Environmental effects on the isotopic composition of these samples were also evaluated.…”
“…The Network aims to raise the awareness of the potential for IRMS in forensic science and to encourage collaboration between various scientific disciplines. The Network held its first conference in September 2002 (Kent, UK) from which three working groups were formed: Explosives, Drugs and General Forensics [26]. A summary of the conference discussions and presentations is available [26].…”
Section: General Forensic Science Applicationsmentioning
“…Stable isotope profiling (SIP), based on sample analysis by isotope ratio mass spectrometry (IRMS), is a new forensic technique that may aid with the source determination of compounds such as explosives and illicit drugs. [1][2][3][4] Several studies have also demonstrated its potential as a tool for determining the place of origin of living humans, unidentified human remains and the identification of disaster victims. [5][6][7][8][9][10] However, if this technique is to be implemented in police investigations and plans for disaster victim identification, a considerable amount of additional research is required.…”
Recent natural catastrophes with large-scale loss of life have demonstrated the need for a new technique to provide information for disaster victim identification when DNA methods fail to yield the identification of an individual, or in other situations where authorities need to determine the recent geographical life history of people. The latter may be in relation to the identification of individuals detained on suspicion of terrorism or in relation to people-trafficking or smuggling. One proposed solution is the use of stable isotope profiling (SIP) using isotope ratio mass spectrometry (IRMS). Exploiting the link between the isotopic signal of dietary components and the isotopic composition of body tissue, the aim of this study was to refine a non-invasive method of analysing human material such as scalp hair and fingernails using SIP and to assess the degree of natural variability in these profiles. Scalp hair and fingernail samples were collected from British and non-British volunteers at Queen's University Belfast every 2 weeks for a minimum of 8 months. Samples were analysed using IRMS to determine their isotopic composition for 13C, 15N, 2H and 18O. The results of this longitudinal study yielded information on the natural variability of the isotopic composition of these tissues. The data demonstrate the relatively low degree of natural variation in the 13C/15N isotopic abundance of scalp hair and fingernails whilst greater variations were recorded in the hydrogen and oxygen values of the same samples. The 15N and 18O values of nail are noticeably more variable than that of scalp hair from the same subject. A hypothesis explaining this trend is put forward based on the faster rate of formation of hair than of nails. This means that there is less time for the compounds forming hair to be affected by biochemical processes that could alter their isotopic signature.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.