2014
DOI: 10.1093/ije/dyu176
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Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways

Abstract: Background: Mendelian randomization uses genetic variants, assumed to be instrumental variables for a particular exposure, to estimate the causal effect of that exposure on an outcome. If the instrumental variable criteria are satisfied, the resulting estimator is consistent even in the presence of unmeasured confounding and reverse causation.Methods: We extend the Mendelian randomization paradigm to investigate more complex networks of relationships between variables, in particular where some of the effect of… Show more

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Cited by 392 publications
(335 citation statements)
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“…18 A method called network Mendelian randomization was recently described to investigate whether some of the effect of an exposure on the outcome may operate through a mediating variable. 19 However, this kind of analysis is beyond the scope of our article.…”
Section: Association Of Single Nucleotide Polymorphisms With Uamentioning
confidence: 95%
“…18 A method called network Mendelian randomization was recently described to investigate whether some of the effect of an exposure on the outcome may operate through a mediating variable. 19 However, this kind of analysis is beyond the scope of our article.…”
Section: Association Of Single Nucleotide Polymorphisms With Uamentioning
confidence: 95%
“…Rather, if a sample has racially homogeneous ancestry and at least some of the population are heterozygous for a genetic polymorphism, the presence of that polymorphism in offspring may be regarded as randomly determined. This is the basis of Mendelian randomization analyses that consider genetic effects on an instrumental variable (e.g., hypnotics consumption) and an outcome variable (e.g., mortality) in order to estimate the component size of the causal pathway leading from genotype to hypnotics consumption to modified mortality [44][45][46][47]. Mendelian randomization eliminates the interference of most confounders in estimating causality, though there remain various complex issues that must be considered.…”
Section: Limitations Due To Genetic Effects and New Research Possibilmentioning
confidence: 99%
“…Mendelian randomisation (MR) is a tool using genetic variants as instrumental variables (IVs) to evaluate whether a risk factor is causally associated with an outcome 11. The objective of this study was to search out whether or not years of education is causally related with the development of RA employing a MR analysis.…”
Section: Introductionmentioning
confidence: 99%