Network pharmacology and
            <i>in vivo</i>
            experiment-based strategy to investigate mechanisms of JingFangFuZiLiZhong formula for ulcerative colitis

Wang, Mengyuan; Li, Jianan; Yin, Yuzhang; Liu, Liying; Wang, Yi-Fei; Qu, Ying; Hong, Yanqiu; Ji, Shuangshuang; Zhang, Tao; Wang, Nan; Liu, Jinlong; Cao, Xu; Zao, Xiaobin; Zhang, Shuxin

doi:10.1080/07853890.2022.2095665

Cited by 6 publications

(1 citation statement)

References 54 publications

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“…TCMSP focuses more on the pharmacological properties of TCM ingredients and systems pharmacology research, making it suitable for analyzing the multitarget mechanisms of these ingredients. TCMSP is widely used in network pharmacology research ( Wang, et al, 2022a ; Cao, et al, 2022 ). Its primary role is to screen the active ingredients of TCM and subsequently identify the corresponding targets of these active ingredients.…”

Section: Introductionmentioning

confidence: 99%

Application of network pharmacology in traditional Chinese medicine for the treatment of digestive system diseases

Zheng,

Liang,

Xue

et al. 2024

Front. Pharmacol.

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With the general improvement in living standards in recent years, people’s living habits, including their dietary habits, have changed. More people around the world do not follow a healthy diet, leading to an increase in morbidity and even mortality due to digestive system diseases, which shows an increasing trend every year. The advantage of traditional Chinese medicine (TCM) in treating digestive system diseases is evident. Consequently, the mechanisms of action of single Chinese herbs and compound Chinese medicines have become the focus of research. The research method of the network pharmacology system was highly consistent with the holistic concept of TCM, and provided a new perspective and theoretical basis for basic research on digestive system diseases. This article summarizes the common databases currently used in research on TCM. It also briefly introduces the basic methods and technologies of network pharmacology studies. It also summarizes the advancements of network pharmacology technology through a comprehensive literature search on PubMed. Based on this analysis, we further explored the role of TCM in treating digestive system diseases, including chronic gastritis, gastric cancer, ulcerative colitis, and liver cirrhosis. This study provides new ideas and references for treating digestive system diseases with TCM in the future and serves as a reference for relevant researchers.

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Section: Introductionmentioning

confidence: 99%

Application of network pharmacology in traditional Chinese medicine for the treatment of digestive system diseases

Zheng,

Liang,

Xue

et al. 2024

Front. Pharmacol.

Self Cite

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Gleditsiae sinensis fructus Pills combined with Jujubae fructus attenuate chronic bronchitis via regulation of AGE-RAGE signaling pathway

Wang,

Kang,

Zuo

et al. 2024

Journal of Ethnopharmacology

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In silico and in vivo demonstration of the regulatory mechanism of Qi-Ge decoction in treating NAFLD

Peng

et al. 2023

Annals of Medicine

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Background Nonalcoholic fatty liver disease (NAFLD), a chronic and progressive liver disease, often causes steatosis and steatohepatitis. Qi-Ge decoction (QGD) shows a good effect against NAFLD in the clinic. But the molecular mechanism for QGD in improving NAFLD is unknown. Purpose This study explored the molecular mechanism of QGD in NAFLD model rats using comprehensive network pharmacology, molecular docking and in vivo verification strategies. Methods Active components and targets of QGD were obtained from public database. The overlapped genes between QGD and NAFLD targets were analyzed by enrichment analysis. Active components and targets were used to predict molecular docking analysis. Finally, seven key targets were screened out and the gene expression were verified in the NAFLD rat’s liver tissues after QGD treatment. Results Fifty-eight common QGD therapeutic targets were associated with NAFLD. Molecular docking demonstrated that seven targets had strong binding ability for the corresponding active ingredients. GO analysis identified 18 biological process entries, which were mainly related to regulation of lipid storage, lipid localization and peptide transport. KEGG analysis identified multiple signaling pathways, which were mainly associated with tumor necrosis factor signaling and NAFLD. In vivo data confirmed that the effect of QGD in the treatment of NAFLD was mainly exerted through improving liver steatosis and inflammatory cell infiltration. Additionally, QGD upregulated the expression of MAPK8 and ESR1 and downregulated the transcriptional expression of IL6, VEGFA, CASP3, EGFR and MYC. These targets may affect lipid metabolism by regulating lipid storage and inflammation. Conclusion The integration of results obtained in silico and in vivo indicated that QGD regulates multiple targets, biological processes and signaling pathways in NAFLD, which may represent a complex molecular mechanism by which QGD improves NAFLD. Key messages QGD intervention is related to multiple biological processes such as inflammation, oxidation and cell apoptosis in NAFLD. Lipid and atherosclerosis, TNF signaling pathway, IL-17 signaling pathway, non-alcoholic fatty liver disease and AGE-RAGE signaling pathway in diabetic complications are the main pathways for QGD intervention NAFLD. The active components of QGD can form good binding with relevant target proteins through intermolecular forces, exhibiting excellent docking activity.

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Network pharmacology and in vivo experiment-based strategy to investigate mechanisms of JingFangFuZiLiZhong formula for ulcerative colitis

Cited by 6 publications

References 54 publications

Application of network pharmacology in traditional Chinese medicine for the treatment of digestive system diseases

Application of network pharmacology in traditional Chinese medicine for the treatment of digestive system diseases

Gleditsiae sinensis fructus Pills combined with Jujubae fructus attenuate chronic bronchitis via regulation of AGE-RAGE signaling pathway

In silico and in vivo demonstration of the regulatory mechanism of Qi-Ge decoction in treating NAFLD

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