Network pharmacology-based approach to investigate the molecular targets of essential oil obtained from lavender for treating breast cancer

Maitisha, Guzhalinuer; Zhou, Junhao; Zhao, Yan; Han, Shuxia; Zhao, Youyun; Abliz, Ablikim; Liu, Guangzhong

doi:10.1016/j.heliyon.2023.e21759

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…Nevertheless, the antiproliferative values found are insignificant compared to those of the other lavender essential oils already tested. For instance, the lavender essential oils showed antitumoral potential in several cell lines tested (Calu-3, MCF-7, U-373, PC3) [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…In a study on lung cancer line Calu-3, the vapor phase of the EO of Lavandula dentata reached high cytotoxic effects in concentrations of 750 µg/mL by reducing more than 80% of the cell viability in MTT assays and around 60% in SRB assays [23]. Through network pharmacology, lavender essential oil was tested on breast cancer cells and induced apoptosis by the manipulation of the PI3K-AKT pathway [24]. Lavandula stoechas essential oil provided antitumor activity against different cancer lines with human gastric AGS cells, reporting over 80% lysis at concentrations of 4 µL/mL (v/v) [25].…”

Section: Introductionmentioning

confidence: 99%

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Chemical Composition and Biological Properties of New Romanian Lavandula Species

Marchidan,

Ortan,

Marcu Spinu

et al. 2023

Antioxidants

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The aims of the present study were to evaluate for the first time the chemical composition and antioxidant, antibacterial, antifungal and antiproliferative potentials of the Romanian George 90 lavender species, as well as parental species, L. angustifolia and L. latifolia. The L. angustifolia, L. latifolia and George 90 essential oils were analyzed by GC-MS/MS and the L. angustifolia, L. latifolia and George 90 hydroalcoholic extracts were analyzed by HPLC-DAD. The antioxidant, antibacterial, antifungal and antiproliferative assays revealed that all the investigated species showed significant activities. The results highlighted the chemical composition and the promising biological potentials of the L. angustifolia, L. latifolia and George 90 lavender species, validating their ethnomedicinal value, which offers potential applications as natural drugs.

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Section: Discussionmentioning

confidence: 99%