Network Pharmacology for Traditional Chinese Medicine Research: Methodologies and Applications

Liu, Yufeng; Ni, Ai; Keys, Anthony C.; Fan, Xiaohui; Chen, Minjun

doi:10.1016/s1674-6384(15)60015-6

Cited by 28 publications

(19 citation statements)

References 67 publications

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“…Per the U.S. Dietary Supplement Health and Education Act of 1994, HDS are not classified as “drug” but as “food (or dietary supplements)” and therefore are not stringently regulated by the U.S. Food and Drug Administration (FDA) without requiring mandatory safety or toxicological evaluations, which are usually required for conventional drugs [ 1 , 2 ]. Since consumers hold the general belief that HDS are made of natural ingredients and therefore are safe [ 3 ], HDS are widely used for multiple purposes, such as improving general well-being, “boosting” the immune system, improving weight loss, building muscle, and as complementary or alternative medications for various diseases [ 4 , 5 ]. HDS are readily accessible over-the-counter in pharmacies, health stores, department stores, and on the internet.…”

Section: Introductionmentioning

confidence: 99%

The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity

Zhu

Seo

Wang

et al. 2018

IJMS

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The growing use of herbal dietary supplements (HDS) in the United States provides compelling evidence for risk of herbal-induced liver injury (HILI). Information on HDS products was retrieved from MedlinePlus of the U.S. National Library of Medicine and the herbal monograph of the European Medicines Agency. The hepatotoxic potential of HDS was ascertained by considering published case reports. Other relevant data were collected from governmental documents, public databases, web sources, and the literature. We collected information for 296 unique HDS products. Evidence of hepatotoxicity was reported for 67, that is 1 in 5, of these HDS products. The database revealed an apparent gender preponderance with women representing 61% of HILI cases. Culprit hepatotoxic HDS were mostly used for weight control, followed by pain and inflammation, mental stress, and mood disorders. Commonly discussed mechanistic events associated with HILI are reactive metabolites and oxidative stress, mitochondrial injury, as well as inhibition of transporters. HDS–drug interactions, causing both synergistic and antagonizing effects of drugs, were also reported for certain HDS. The database contains information for nearly 300 commonly used HDS products to provide a single-entry point for better comprehension of their impact on public health.

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Section: Introductionmentioning

confidence: 99%

The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity

Zhu

Seo

Wang

et al. 2018

IJMS

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“…The network of drug action is built by drug-target networks and biological networks. Thus, network pharmacology could be used to investigate the complex dynamics of interconnected molecular and organic systems in drug discovery, development, and drug safety [71,72]. The recent progress in applying the network pharmacology in Chinese herbal medicine research is shown in the following seven aspects, such as predicting new drug targets, action mechanism, new drug discovery, drug evaluation for PD/PK, safety and toxicology, quality control, and bioinformatics.…”

Section: Bioinformatics In Dili/hili Researchmentioning

confidence: 99%

“…Tremendous amount of information obtained supports the following investigations: (1) CHM network is applied to predict the interaction of CHM molecules-pathway and formula contained; (2) interaction of target and target protein is used to study the mechanism of CHM; (3) the pharmacological responses of the active molecules from a population of molecules and combined drugs at the levels of multitargets, indications, side effects, and molecular-drug-targets-disease relationships are evaluated and summarized; (4) systems biology and translational medicine from basic research to clinical outcome are combined; and (5) the possible active molecules and active targets in CHM prescriptions are predicted [72]. The successful application of the network toxicology to safety and toxicology study of CHM is extremely beneficial to identify the toxic ingredients and potential incompatibility of CMMs.…”

Section: Bioinformatics In Dili/hili Researchmentioning

confidence: 99%

A Case Report of Liver and Renal Function Changes in Stroke Patients Taking Long-term Herbal Medicine

Kim¹,

Kim²,

Go³

et al. 2017

J Int Korean Med

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In general, herbal medicines have been considered as safe by the general public, since they are naturally occurring and have been applied in treatment for over thousands of years. As the use of herbal medicine is rapidly increasing globally, the potential toxicity of herbal drugs, in particular drug-induced liver injury (DILI), has now become a serious medical issue. According to the literature, the authors analyzed and discussed the hepatotoxicity problem of Chinese herbal medicines (CHM), including global overview on herbal-induced liver injury (HILI), current research progress on toxic CHM, diagnosis and treatment of HILI, and modern approaches and technologies of study of hepatotoxicity. As to promote the recognition of HILI and tackle the issue, a guideline for the diagnosis and treatment of HILI has recently been drafted by Chinese scientists. As suggested by the guideline, the hepatotoxicity issue of CHM, as a matter of fact, is overestimated. Up to date, the investigation of hepatotoxicity of CHM is now booming with worldwide application of CHM. This review therefore provides useful information for investigating hepatotoxicity of herbal medicine and characterizing DILI caused by CHM. In addition, authors describe in which way further efforts should be made to study the rationale of CHM and liver injury.

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“…The research on TCM prescriptions has been using the research method of chemical drugs for a long time, by combining the separation of chemical components of TCM and simple screening of active compounds to study action mechanism. Although this method can discover some of the pharmacological substance basis and mechanism of action of TCM prescriptions, it is difficult to really interpret the overall mechanism of TCM action, due to TCM prescription has the characteristics of multi-component multi-target synergy and indication function diversity [7,8]. These restrictions have limited the promotion and use of Chinese medicine internationally.…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology-based study on the mechanism of Yiganling capsule in hepatitis B treatment

Lü

Zhou

et al. 2020

BMC Complement Med Ther

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Background: Yiganling (YGL) capsule is a traditional Chinese medicine preparation consisting of eight herbs that has been clinically proven to have a favorable treatment effect on Hepatitis B (HB). However, due to its multiple targets and multi-pharmacological effects, the mechanisms of YGL capsule in the treatment of HB are unknown. Methods: First, the chemical constituents of YGL capsules were obtained from the Chinese medicine database, and YGL capsules were constructed. Second, active compounds were screened by the ADME model. The target fishing model was used to screen the corresponding targets of active compounds and to construct a compounds and compound targets network. Using human disease databases and literature mining, we systematically identified genes associated with HB, constructed disease-specific protein-protein interaction networks, and performed clustering and enrichment analyses of these networks. These networks were then merged to obtain a compounddisease target network, and cluster and enrichment analyses were performed on the compound-disease target network to acquire a compounds-disease targets-mechanism network and a clustering network. Results: We successfully built eight pharmacological network diagrams, including four primary networks and other network maps. The four dominating network maps included a HB disease-associated protein-protein interaction network, a YGL capsule compounds-target network, a YGL capsule ingredient target-HB disease target network, and a YGL-HB disease mechanism network. Other networks included a pathway of HB disease targets, the HB disease protein-protein interaction cluster analysis network, and the YGL-HB target clustering network. Conclusion: This study successfully forecasted, illuminated, and confirmed the synergistic effects of HB disease molecules and discovered the potential of HB relevant targets, clusters, and target-related biological processes and signaling pathways. Our research not only provides theoretical support for the molecular and pharmacological mechanisms of YGL capsule in HB treatment, but also provides new research methods for the study of the other traditional Chinese medicinal compounds.

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Network Pharmacology for Traditional Chinese Medicine Research: Methodologies and Applications

Cited by 28 publications

References 67 publications

The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity

The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity

A Case Report of Liver and Renal Function Changes in Stroke Patients Taking Long-term Herbal Medicine

Network pharmacology-based study on the mechanism of Yiganling capsule in hepatitis B treatment

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